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House holiday rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: These houses are highly rated for location, cleanliness and more.

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Guest favourite
The exterior of a two-story residence is shown, featuring a classic design with a stone façade and wooden accents. Lush greenery surrounds the entrance, where steps lead to the upper level. Two friendly dogs can be seen in the foreground, adding a welcoming touch to the scene.
Home in Panama City
4.87 out of 5 average rating, 86 reviews

Central|Confort|surrounded by nature|Wifi|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo. Descansar en una hamaca en el balcón lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo (WiFi de alta velocidad); en familia o en grupos de amigos. Casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. (Cerca Terminal de Buses, Metro Tren, Albrook Mall, parque Metropolitano, Aeropuerto Marcos Gelabert, Casco Antiguo, Coast Way de Amador, Canal de 🇵🇦)

Guest favourite
An inviting living area features a grey reclining chair and a light wooden coffee table with decorative plants. In the background, a dining table set for four is visible, along with a stone accent wall that adds texture. Natural light fills the room through a nearby window.
Home in Panamá
4.95 out of 5 average rating, 38 reviews

Cantabria House - 10 minutes from the Airport

Spacious and comfortable home just 10 minutes from Tocumen Airport and only 200 meters from the Metro. Perfect for families, groups, or business trips. Fast 500 Mbps Wi-Fi, 3 bedrooms, 2 full bathrooms, fully equipped kitchen, air conditioning throughout the house, cable TV, patio with outdoor furniture, private parking, and self check-in. Long layover, family trip, or work in the city? This home has it all: comfort, location, and privacy. Book now and feel at home from the very first moment!

Guest favourite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
5 out of 5 average rating, 51 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Top Guest favourite
Home in Panamá
4.92 out of 5 average rating, 38 reviews

Apartamento Lilia Airport 1

"Experimenta una estancia cómoda y conveniente en nuestro acogedor apartamento, ubicado a solo 10 minutos del aeropuerto Tocumen. Equipado con todas las comodidades necesarias para tu descanso, desde conexión WiFi hasta una cocina equipada, este espacio te ofrece la oportunidad de relajarte y recargar energías. Disfruta del confort del aire acondicionado, agua caliente/fria en el baño, una cama y sofá cama para tu comodidad, televisión con cable , y toallas y sobrecama para tu conveniencia.

Guest favourite
A spacious bed is featured with two decorative pillows against a textured headboard. Soft natural light streams through partially covered windows, while a minimalist side table and shelf are positioned nearby, providing additional storage and a clean aesthetic.
Home in Panamá
4.74 out of 5 average rating, 23 reviews

apartment-studio-kitchen-wifi6-tv-comfort-quiet

welcome to my home, designed especially for you! I tell you that our studio apartment cost with its private bathroom,very comfortable, a super comfortable double bed,with its air conditioning, a kitchen, a refrigerator. It has a digital lock for added security. 🙂 if you come for work we have the ideal table so you can work comfortable,the place is centrally located,very quiet and is just steps from the Este coast.. (business and tourist center). If you are interested, you can rent a car!

Superhost
A bright living room features two gray sofas positioned around a wooden coffee table on a jute rug. Large windows allow natural light to fill the space, framed by sheer white curtains. A wall-mounted Smart TV offers streaming options, enhancing relaxation.
Home in Panamá
4.92 out of 5 average rating, 64 reviews

Unique 4 room house - direct access to the beach

Welcome to Casa Playa, your haven in the heart of Casco Viejo! This elegant property blends the historic charm of the area with modern comfort and style. It features 4 cozy bedrooms, each with its own private bathroom, a fully equipped kitchen, living and dining areas, and an in-unit laundry center. Perfect for groups of up to 8 guests to share in an exclusive and comfortable setting. Enjoy an unforgettable stay in a warm, spacious, and fully equipped space.

Top Guest favourite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in Panama City
4.81 out of 5 average rating, 109 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Superhost
A bright bedroom features a spacious bed with a neutral gray quilt and two matching pillows. Natural light enters through multiple windows, which are flanked by light curtains. An air conditioning unit is mounted on the wall, adding comfort to the space.
Home in Panamá
4.62 out of 5 average rating, 29 reviews

Beautiful spacious full apartment near Albrook

Spacious and cozy apartment in a very quiet area surrounded by nature. The apartment is complete, everything is ready to welcome you. All services are included. Close to the Miraflores locks, the City of Knowledge, the Metropolitan National Park, Cerro Ancón, Albrook Terminal. Near the Los Rios pool. Accessibility for buses and taxi. For security reasons, cameras at the main entrance, terrace and patio. No cameras in indoor spaces.

Guest favourite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.93 out of 5 average rating, 130 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Top Guest favourite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.93 out of 5 average rating, 377 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Superhost
A modern kitchen is featured with sleek granite countertops and stainless steel appliances. Framed wall art adds a touch of style. A small dining table is visible in the background, alongside window blinds that filter natural light.
Home in San Miguelito
4.89 out of 5 average rating, 18 reviews

Casa Santa by SS • 3BR Perfect Stay Near City

This memorable place is anything but ordinary. This stylish place is perfect for group of persons or family trips. Conveniently located next to shopping malls and supermarkets you’re literally minutes from the train station and just minutes to the city. San Antonio is a safe place for families. Enjoy a cozy silent place with everything you can need for your stay.

Guest favourite
The interior showcases a cozy seating area with a brown sofa and two clear chairs around a glass table. A spacious bed with warm bedding is positioned against the wall. Natural light enters through large windows adorned with soft curtains, highlighting decorative shelves and artwork.
Home in Panamá
4.92 out of 5 average rating, 159 reviews

Golden Space | By Paradox

PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.

Popular amenities for Panama City house rentals

Quick stats about house rentals in Panama City

  • Total holiday rentals

    Explore 470 holiday rentals in Panama City

  • Nightly prices starting at

    Panama City holiday rentals start at $15 AUD per night before taxes and fees

  • Verified guest reviews

    Over 7,270 verified reviews to help you choose

  • Family-friendly holiday rentals

    180 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 160 rentals that welcome pets

  • Holiday rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    220 properties have a dedicated workspace

  • Wi-Fi availability

    430 of Panama City holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wi-Fi and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore

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