
Apartment holiday rentals in Panama City
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Top-rated apartment rentals in Panama City
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Apto 4 min from Tocumen Airport | 24-hr check-in
Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Lovely Spacious 3BR in Casco Viejo w/Balcony
Welcome to Casa Bandera, your retreat in the heart of Casco Viejo! Located in Panama's iconic Casco Antiguo, this elegant apartment combines the area's historic charm with modern comfort. It features three cozy bedrooms, each with a private bathroom; an in-house laundry center, a fully equipped kitchen, a living room, and a dining room, perfect for sharing in an exclusive setting. Perfect for up to six people. Enjoy an unforgettable stay in a cozy and fully equipped environment.

Best Location-Fancy Apartment in CascoViejo
Experience absolute luxury in our fully remodeled loft, with access to a 360° rooftop, where you'll enjoy the best views of the city. The building features an elevator for your convenience. Located right in front of a plaza with renowned restaurants, the location is unbeatable, and security is guaranteed. Live an exceptional experience in Panama’s Casco Antiguo! Book now and immerse yourself in the luxury, perfect location, and amazing views that our apartment has to offer!

Cozy 2 Bedroom w/ Splash Pool
Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Unique Luxury 3-story Loft at the Yoo
Experience the luxury of a world renowned Philippe Starck designed building. Our 3-bedroom sanctuary is a unique 3-story loft that boasts breathtaking city views, an open-plan kitchen, sleek marble floors, and premium amenities. Steps away from Panama City’s premier attractions, shopping, and dining. Dive into top-tier amenities: a pristine pool, state-of-the-art gym, relaxing spa, and three of the best restaurants in the city! Embrace Panama in unmatched style.

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Private parking & rooftop | Studio Casco Center
This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Studio apartment in the heart of Casco
Welcome to Casa Pérez, your retreat in the heart of the Old Town! Enjoy a prime location and the best views from a spectacular private balcony facing the most iconic square in the Casco. Ideal for 3 people, this cozy and bright one-bedroom apartment includes Wi-Fi, air conditioning, living room, dining room, equipped kitchen, washing machine and elevator for your comfort. Enjoy an unforgettable stay in a warm and fully equipped atmosphere.

The best view of the Old Town
Welcome to this charming accommodation located in the heart of Casco Viejo, in front of one of the most emblematic squares in Panama, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.
Popular amenities for Panama City apartment rentals
Weekly apartment rentals

Private Apartment in Poin, Ocean View.

1bd/2Bthrm East Coast-Panama

Apartment with balcony in the Casco Viejo

Central and safe + rooftop with pool and views

33rd floor with an amazing view of the ocean, pool + gym + parking

Modern Suite in the Heart of the City

Comfortable apartment in Panama City.

Casco Viejo / Penthouse w/ Terrace & Pool Access
Private apartment rentals

Lovely & Cozy central apartment in Casco Viejo

Panoramic View Penthouse with Luxury Amenities

w* | Luxury 2BR in Old Town

Modern apartment in Obarrio • 1 bed + sofa bed

Spectacular Bay View • 1BR • Pool/Gym and +

Amazing experience in Casco Viejo historical site3

24o Penthouse, Unique Design, 2 Balconies, Ocean View

Luxury Sky-High Ocean View
Apartment rentals with a hot tub

3 bedroom penthouse with spectacular views!

Luxury 2BR Suite with Pool & Views

Luxury Beachfront Apartment Near Panama City

New Flat with Ocean + City Views

Tropical Paradise at Playa Bonita

Panama Dream View Escape

On the beach. Entire floor with oceanfront terrace

BusinessTripFlat/Comfy/well located/AAs/Queen beds
Quick stats about apartment rentals in Panama City

Total holiday rentals
Explore 2,890 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at $14 AUD per night before taxes and fees

Verified guest reviews
Over 79,200 verified reviews to help you choose

Family-friendly holiday rentals
900 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 1,090 rentals that welcome pets

Holiday rentals with a pool
1,840 properties feature pools

Rentals with dedicated workspaces
1,770 properties have a dedicated workspace

Wi-Fi availability
2,760 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
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