
Holiday houses in Panama City
Find and book unique accommodation on Airbnb
Quick stats about holiday rentals in Panama City

Total holiday rentals
Explore 5,590 holiday rentals in Panama City

Verified guest reviews
Over 149,670 verified reviews to help you choose

Family-friendly holiday rentals
1,780 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 1,940 rentals that welcome pets

Holiday rentals with a pool
2,960 properties feature pools

Rentals with dedicated workspaces
3,570 properties have a dedicated workspace

Wi-Fi availability
5,430 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Self check-in, Gym and BBQ grill across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated holiday rentals in Panama City
Guests agree: these stays are highly rated for location, cleanliness and more.

Apto 4 min from Tocumen Airport | 24-hr check-in
Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!
LocationValueWalkability

Casa Condal - Your Luxury Retreat in Cerro Azul
Birdwatching • Romantic Getaway • Remote Work Escape the city. Breathe pure mountain air. Reconnect with nature. Casa Condal - private, modern, sustainable and regenerative hospitality inside Chagres National Park WiFi 65" Smart TV. Sound Bar Self check-in Private parking Fully equipped kitchen 220mts. private trail Deck-Mirador + FirePit, panoramic view of the mountains and valley King bed + Full size sofa bed BBQ Wheelchair accessible 40 min from Tocumen Airport. 1 hr from Panama city.
FamilyLocationDecor

CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES
Espectacular ático Duplex en Panamá Casco antiguo, de 265 M2 con balcones, terrazas privadas exterior, cuenta con una salón jardín interior, un comedor, 3 hab. (+ sofá cama en studio), recientemente reformado con concepto Loft, diseño exclusivo único y confortable, en la mejor zona del Casco viejo, perfecto para relajarse y desconectar, cocina , lavavajilla, sala con lavadora. piscina compartida, asc, portero 24-7, no se permiten niños que no sepan nadar, gran variedad de ocio en la zona.
FamilyLocationCheck-in

Modern apt ocean view in heart of Panamá yoo tower
Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.
FamilyValueIndoor spaces

The View of Casco: Designer Loft with best Balcony
Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife
ValueFamilyCheck-in

Colonial style with calicanto and a private balcony
Welcome to a cosy apartment where the charm of the calicanto walls blends with warm details and a perfect balcony to enjoy the atmosphere and the view of the Old Town. We are in a prime location on one of the main avenues of the Casco. From here, you can easily access historical sites, restaurants, cafes, bars and charming spots. The idea is for you to arrive, feel comfortable and enjoy the city at your own pace, whether you're alone, with your partner or with your family.
FamilyValueComfort

Patty’s Casco 2BR Loft | Balcony & Personal Touch
“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!
LocationValueDecor

Walk to Everything | Luxury Stay in Casco Viej
Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.
ValueLocationBathroom

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.
FamilyLocationLaundry

Private parking & rooftop | Studio Casco Center
This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location
LocationFamilyCondition

Loft 3b Old Town Best! It's 150 m2 (492 feet)
Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.
LocationFamilyCleanliness

Most Beautiful Loft in the Heart of Casco Viejo
Discover Casco Viejo from this beautiful loft, perfectly located. Casco Viejo, UNESCO World Heritage Site, known for its colonial buildings, and iconic streets. This vibrant neighborhood offers many restaurants, coffee places, museums, and an exciting night life. Just steps from Fonda Lo Que Hay, ranked among Latin America's Top 50 culinary destinations. Close to MYKA Greek Yogurt and the iconic La Compañía Hotel.
LocationValueComfort
Popular amenities for Panama City holiday rentals
Other great holiday rentals in Panama City

Mountain Retreat
FamilyLocationView

Loft in Casco Antiguo, Joya Colonial
FamilyValueComfort

Luxury apt in Panama City 2 Rooms 3 Baths
ValueLocationDecor

The Crystal House: Luxury Modern Wood Cabin
LocationFamilySleep quality

Bright Designer Residence w/ Skylight + Rooftop
LocationNearbyShared spaces

Panoramic Casco Viejo Lookout in The Sands
ValueLocationView

Gorgeous Flat in the best location in Casco Viejo
FamilyValueOutdoor spaces

Peaceful Stay in the Heart of Casco
FamilyLocationIndoor spaces
Destinations to explore
- Cartagena Holiday rentals
- Cahuita Holiday rentals
- Bahía Ballena Holiday rentals
- Coveñas Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Bocas del Toro Province Holiday rentals
- Uvita Holiday rentals
- Boquete Holiday rentals
- San Andrés Holiday rentals
- Rio Hato Holiday rentals
- El Valle Holiday rentals
- Valle de Antón Holiday rentals
- Family-friendly rentals Panama City
- Rentals with lake access Panama City
- Serviced apartment rentals Panama City
- Rentals with a sauna Panama City
- Pet-friendly rentals Panama City
- Boutique hotels Panama City
- Apartment rentals Panama City
- Beachfront rentals Panama City
- Bed and breakfasts Panama City
- Rentals with a hot tub Panama City
- Hotel rooms Panama City
- Guesthouse rentals Panama City
- Cabin rentals Panama City
- Hostel rentals Panama City
- Townhouse rentals Panama City
- Condo rentals Panama City
- Private suite rentals Panama City
- Rentals with an accessible height bed Panama City
- Loft rentals Panama City
- Rentals with beach access Panama City
- Rentals with breakfast Panama City
- Rentals with pools Panama City
- Villa rentals Panama City
- House rentals Panama City
- Waterfront rentals Panama City
- Things to do Panama City
- Art and culture Panama City
- Landmarks Panama City
- Cooking Panama City
- Wildlife Panama City
- Tours Panama City
- Sports activities Panama City
- Food tours Panama City
- Sightseeing Panama City
- Tastings Panama City
- Food and drink Panama City
- Outdoors Panama City
- Cultural tours Panama City
- Nature and outdoors Panama City
- Things to do Panamá Province
- Cultural tours Panamá Province
- Sports activities Panamá Province
- Water sports Panamá Province
- Nature and outdoors Panamá Province
- Cooking Panamá Province
- Food tours Panamá Province
- Outdoors Panamá Province
- Wildlife Panamá Province
- Landmarks Panamá Province
- Tours Panamá Province
- Sightseeing Panamá Province
- Food and drink Panamá Province
- Art and culture Panamá Province
- Tastings Panamá Province
- Things to do Panama
- Landmarks Panama
- Water sports Panama
- Nature and outdoors Panama
- Food tours Panama
- Sports activities Panama
- Tastings Panama
- Sightseeing Panama
- Wildlife Panama
- Outdoors Panama
- Cultural tours Panama
- Tours Panama
- Food and drink Panama
- Cooking Panama
- Art and culture Panama







