Hotel holiday rentals in Panama City

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Top-rated hotels in Panama City

Guests agree: These hotels are highly rated for location, cleanliness and more.

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Hotel room in San Felipe

4.92 out of 5 average rating, 49 reviews

5. Beautiful Boutique Apart-Hotel-Views & Services

La Isabela Suites is a Boutique apart-hotel built on the concept of space, elegance and comfort. Located in the heart of Casco Antiguo, only steps from culture, markets, dining, and bars, and with a unique quality of service. La Isabela Suites offers an alternative type of travel, away from the small, standardized and impersonal massive hotel rooms without the inconvenience of a self-catering apartment. Because we understand that the true luxury means not having to worry about anything.

Casa particular in Panamá

La Husseyenda- Birdwatcher Haven

A Birdwatcher’s and Jungle Paradise nestled in Los Altos de Cerro Azul, this 3-level villa offers breathtaking Lake Alajuela views, stunning sunsets, and endless birdwatching opportunities! Spot hummingbirds, tanagers & toucans from the terrace while howler monkeys call in the distance. Family & pet-friendly with a fenced garden, spacious BBQ, & a fully equipped kitchen. Relax in nature’s paradise—your jungle escape awaits! Make some memories at this unique and family-friendly place.

Guest favourite

Hotel room in Panamá

4.9 out of 5 average rating, 10 reviews

Very Nice Downtown Panamá Hotel Free Parking

Welcome to the beautiful Aloft Panamá hotel This is a very nice and safe hotel located in the San Francisco area of Panamá with beautiful city views. King or 2 queen based on availability (Feel free to make request prior to booking if you have a preference) All rooms non smoking ($350 fine) No pets allowed Must be 21 with id to checkin Must have credit card for incidentals Checkin time starts at 3pm Checkout time before noon Free Parking Pool Bar/Lounge

Hotel room in El Cangrejo

4.71 out of 5 average rating, 31 reviews

Hotel room #3 one block from the Metro.

Disfruta de acceso ràpido a los destinos más populares de Ciudad de Panamà, centros comerciales, restaurantes, y áreas turísticas. Cuarto de hotel con baño privado, aire acondicionado, cable TV, recepciòn con 24 horas de servicio y estacionamientos sujetos a disponibilidad. Cerca de restaurantes y casinos. A una cuadra de la estaciòn del Metro que lo lleva en 10 minutos a Albrook Mall, el Centro Comercial más grande de Panamà.

Guest favourite

Private room in Panamá

4.82 out of 5 average rating, 22 reviews

Desk & Dream Room

Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

Superhost

Hotel room in Marbella

4.83 out of 5 average rating, 6 reviews

In the heart of the city.

Hotel Mio Panama we are a 4 star hotel located in Panama City, in the heart of the financial area. Our main goal is to meet any needs of the client, offering the best services to ensure a comfortable and peaceful stay. Among our modern facilities, you will find a pool, spacious and comfortable rooms, gym, meeting rooms, and rooftop. If you like to travel with your pet, we are pet friendly.

Private room in Punta Pacifica

5 out of 5 average rating, 4 reviews

Casa Orquídea Panama City #1

Casa Orquídea is a Beautiful Residential located in the heart of Panama City. Welcome to the jewel of Paitilla surrounded by buildings, sea, and beautiful greenery, this house is the best kept secret in one of the most exclusive areas of the city, with safe walking spaces. This is the urban paradise for nature lovers. Unplug and relax in the middle of town!

Guest favourite

Hotel room in Panamá

4.86 out of 5 average rating, 43 reviews

Private rooms Sofia's B&B Hostal Boutique

Boutique hostel-style accommodation, we have 7 comfortable private rooms with bathroom, for a total capacity of 18 guests. The rate shown by Airbnb for your reservation is for 2 guests per room, i.e., guests will need to share beds and/or rooms. If you require a special room layout for your group, please contact the host first, as the rate may vary.

Guest favourite

Hotel room in Panamá

4.85 out of 5 average rating, 103 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.