
Holiday houses in Panama
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Panama
Guests agree: these stays are highly rated for location, cleanliness and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Luxury apt in Panama City 2 Rooms 3 Baths
El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Cozy open space, unique jungle views, river access
An open-style jungle home with mesmerizing treetop and mountain views. Located 10 minute walk to the beach, with a trail that leads to the River. The house is not childproof! It has three individual bedrooms, each with its own key. The price is based on the number of guests. The entire house is always yours. The house offers fiber optic WiFi and two dedicated workspaces. The property is surrounded by large trees, naturally keep the house cool and provide shelter for birds and wildlife.

Boquete Bees and Butterflies Casitas
Romantic setting, immersed in nature and yet close to town. Fibre Optic Internet. Nestled in extensive tropical gardens on a traditional Boquete Coffee Estate. Abundance of birds, feeders and native bee hives. We are home to Panamas largest butterfly exhibit and specialty honey company. We offer a hearty breakfast. We can accommodate 4 px but booking price including breakfast is for 2px. We charge an additional $15 per person over 12 yrs, an additional $10 for children under 12 yrs

FACING THE SEA Cacique (Portobello Park)
A house! A real glass island in the heart of the jungle! In the middle of the Portobello National Park (access only by 4x4 AWD) nestled at the top of the hill, between sky/sea, away from all eyes, a transparent house where glass embraces nature on all sides creating a unique connection between the inside and the outside, ideal for resting, disconnecting, comfortable, spacious, cool (central air conditioning), exclusive. It is the witness of a grandiose spectacle that awaits you!

Pebos Reef Apt 2 · Beachfront · Sea View Terrace
This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Bamboo Cabin
Take it easy at this unique and tranquil getaway. The Bambu Cabana is surrounded by bamboo and features a unobstructed view of Vulcan Baru. Wake up to see the sun reflecting off of the mountain, visible clearly through large floor to ceiling wrap around windows. Do some work at the desk or relax in the recliners or outdoor balcony chairs. Enjoy a refreshing shower or long soak in the large bathtub. The cabana includes a well stocked kitchenette, and washer dryer combo.

Orange House - Over The Water Rentals
Enjoy golden sunsets across the bay from the Orange House at Over The Water Rentals. Home away from home in a tropical paradise. Relax on your outdoor lounge or explore the bay. The house has snorkel gear, SUP's & kayaks for guests to use for free. Located close to town & airport in a quiet local neighborhood. The house features a king size master bedroom & queen guest room, spacious hot water shower, handmade organic toiletries, fully equipped kitchen & high speed wifi

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Casa Samambaia - sea view tropical paradise w pool
With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Cocovivo Mangrove Tree house
This secluded loft-style treehouse sits on stilts above the water, 30 feet from our colorful coral reef. Transparent and airy but bug proof walls let you enjoy the fresh ocean breeze and views while keeping you safe and cozy. When a sloth comes to visit, no need to leave the house to see him! Blend in with the surroundings of mangrove, lagoon and jungle, and enjoy water and reef access from your own deck. Bright and airy, 100% eco-conscious.
Popular amenities for Panama holiday rentals
Other great holiday rentals in Panama

Luxury Apartment With Private Beach And Sea View

Casita del Mar 'Over the water' Villa

A Remote Paradise in nature - Ocean View

Private oasis with Ocean Views and Pool

Luxury Mid-Century Apartment In Casco Viejo

Cabin with river view

Hill House-Sunset Ocean Views/Surf/Jungle

Casa del Lago 2025
Destinations to explore
- Fitness-friendly rentals Panama
- Dome rentals Panama
- House rentals Panama
- Farmstay rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Pet-friendly rentals Panama
- Aparthotel rentals Panama
- Hotel rooms Panama
- Rentals with an accessible height bed Panama
- Rentals with a home theatre Panama
- Boutique hotels Panama
- Nature eco lodge rentals Panama
- Island rentals Panama
- Lakehouse rentals Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Chalet rentals Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Rentals with breakfast Panama
- Townhouse rentals Panama
- Tree house rentals Panama
- Rentals with beach access Panama
- Rentals with a hot tub Panama
- Beach house rentals Panama
- Tent rentals Panama
- Smoking-friendly rentals Panama
- Rentals with a sauna Panama
- Rentals with a patio Panama
- Guesthouse rentals Panama
- Rentals with a washing machine and dryer Panama
- Loft rentals Panama
- Waterfront rentals Panama
- Rentals with a fireplace Panama
- Shipping container rentals Panama
- Bed and breakfasts Panama
- Bungalow rentals Panama
- Cottage rentals Panama
- Condo rentals Panama
- Rentals with a fire pit Panama
- Tiny house rentals Panama
- Rentals with lake access Panama
- Boat rentals Panama
- Apartment rentals Panama
- Holiday home rentals Panama
- Beach condo rentals Panama
- Family-friendly rentals Panama
- Earth house rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Rentals with pools Panama
- Villa rentals Panama




