
Family-friendly holiday rentals in Panama City
Find and book unique family-friendly homes on Airbnb
Quick stats about holiday rentals that are family-friendly in Panama City

Total holiday rentals
Explore 1,660 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at $14 AUD per night before taxes and fees

Verified guest reviews
Over 49,930 verified reviews to help you choose

Pet-friendly accommodation
Find 710 rentals that welcome pets

Holiday rentals with a pool
930 properties feature pools

Rentals with dedicated workspaces
1,020 properties have a dedicated workspace

Wi-Fi availability
1,590 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated family-friendly rentals in Panama City
Guests agree: These family-friendly homes are highly rated for location, cleanliness and more.

Apto 4 min from Tocumen Airport | 24-hr check-in
Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Best Location – Spacious Luxury Apartment for 8
Welcome to our spacious and elegant apartment, designed to comfortably host up to 8 guests in the heart of Casco Viejo. Located directly in front of one of the most beautiful and lively plazas in the historic district, you’ll be surrounded by top restaurants, cafés, and vibrant city life. The building also features an elevator for your convenience and access to a rooftop, perfect for relaxing after a day exploring the city. Its prime location allows you to easily discover the best attractions

Casco Viejo 360° View Old Tower Penthouse
Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Luxury Mid-Century Apartment In Casco Viejo
Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

Modern apt ocean view in heart of Panamá yoo tower
Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Patty’s Casco 2BR Loft | Balcony & Personal Touch
“Feel at home in Casco Viejo—personally welcomed by your hosts, Patty & Rudy.” Stay in the Heart of Casco Viejo with Patty’s Casitas! Prime Casco Viejo Location | Quiet, Convenient & Charming Stay steps from restaurants, cafés, bars, and plazas—right by the El Rey boutique supermarket and the waterfront promenade. This peaceful spot is rare in Casco, tucked away from rooftop noise and perfectly located at the entrance of the neighborhood for easy in & out access!

Beautiful House in Panama w/ King Beds + Pool
Beautiful home in Punta Paitilla featuring 6 bedrooms, 5.5 bathrooms, and 8 beds, comfortably accommodating up to 16 guests. Enjoy a private pool, in-home gym, and spacious, modern living areas designed for families, groups, or business travelers. The layout offers both privacy and comfort across two levels. Located in one of Panama City’s most exclusive neighborhoods, just minutes from restaurants, shopping centers, supermarkets, and the Cinta Costera.

The apartment of a legendary Panamanian footballer
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Private guest house in Ancón
Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.

Beautiful apartment in Casco Viejo ST. George D
Welcome to our spacious and charming apartment in Casco Viejo. Located in a vibrant and historic neighborhood. You will love the warm atmosphere created by the lime and pebble walls, in perfect harmony with our modern and elegant decor. The space is large and comfortable, ideal for relaxing after a day exploring the city. As a host, I'm available 24/7 to answer questions and make sure you make the most of your stay.

CASA SAEMA "C" -Design Apt, Casco Viejo Panama
Hermoso Apto en Panamá Casco antiguo, renovado con materiales de primera calidad, diseño exclusivo y confortable, en la mejor zona del Casco viejo, perfecto para relajarse y desconectar, cocina con lavavajillas y lavadora, El edificio cuenta con una piscina en patio central compartida Aptos, portero 24-7, gran variedad de ocio en la zona, no se permiten niños que no sepan nadar.
Popular amenities for Panama City family-friendly rentals
Family-friendly home rentals with a hot tub

Luxury Apartment With Private Beach And Sea View

Luxury 2BR Suite with Pool & Views

Cabin near the city, luxurious treehouse

Apartment Av. Balboa, Yoo&Arts

New Flat with Ocean + City Views

Unique Historic House in Casco

Tropical Paradise at Playa Bonita

Panama Dream View Escape
Family- and pet-friendly home rentals

Cozy Casco Viejo Apartment

Loft in Casco Antiguo, Joya Colonial

Luxury Centric 2BR Apartment in Casco Viejo

Modern, central and comfortable (001)

Lovely & Cozy central apartment in Casco Viejo

Great and modern apartment-Old Town

Full apartment in Panama

Villas La Fontana Spacious ApartaSuite - Pool 104
Family-friendly home rentals with a pool

Modern studio with ocean view / central / prime

Modern and luxurious oceanfront apartment

Unique Luxury 3-story Loft at the Yoo

Calle 50, Luxury and comfort

Cerro Azul, Country House with Heated Pool.

59A apartment with panoramic view, with 2 bedrooms

24o Penthouse, Unique Design, 2 Balconies, Ocean View

Casa Vidal - The Only House in Casco Viejo
Destinations to explore
- San Andrés Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Uvita Holiday rentals
- Boquete Holiday rentals
- Playa Blanca Holiday rentals
- Valle de Antón Holiday rentals
- Coveñas Holiday rentals
- Ancón Holiday rentals
- Bahía Ballena Holiday rentals
- Limon Holiday rentals
- David Holiday rentals
- Playa Venao Holiday rentals
- Rentals with lake access Panama City
- Waterfront rentals Panama City
- Serviced apartment rentals Panama City
- Fitness-friendly rentals Panama City
- Rentals with a home theatre Panama City
- Apartment rentals Panama City
- Beachfront rentals Panama City
- Hostel rentals Panama City
- Guesthouse rentals Panama City
- Rentals with an accessible height bed Panama City
- Rentals with outdoor seating Panama City
- Rentals with a sauna Panama City
- Loft rentals Panama City
- Rentals with a fireplace Panama City
- Townhouse rentals Panama City
- Hotel rooms Panama City
- Rentals with a hot tub Panama City
- Smoking-friendly rentals Panama City
- Boutique hotels Panama City
- Pet-friendly rentals Panama City
- House rentals Panama City
- Rentals with breakfast Panama City
- Condo rentals Panama City
- Bed and breakfasts Panama City
- Rentals with a washing machine and dryer Panama City
- Rentals with pools Panama City
- Cabin rentals Panama City
- Rentals with a patio Panama City
- Rentals with a fire pit Panama City
- Private suite rentals Panama City
- Rentals with an EV charger Panama City
- Rentals with beach access Panama City
- Villa rentals Panama City
- Family-friendly rentals Panamá Province
- Family-friendly rentals Panama
- Things to do Panama City
- Food and drink Panama City
- Sightseeing Panama City
- Nature and outdoors Panama City
- Art and culture Panama City
- Tours Panama City
- Things to do Panamá Province
- Nature and outdoors Panamá Province
- Sightseeing Panamá Province
- Food and drink Panamá Province
- Tours Panamá Province
- Art and culture Panamá Province
- Things to do Panama
- Nature and outdoors Panama
- Entertainment Panama
- Art and culture Panama
- Sports activities Panama
- Food and drink Panama
- Sightseeing Panama
- Tours Panama






