
Holiday houses in Panama City
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Top-rated holiday rentals in Panama City
Guests agree: these stays are highly rated for location, cleanliness and more.

Modern apartment in the heart of Obarrio
This apartment stands out for its privileged location in Obarrio, with a modern and cozy design. Located on the 14th floor, it offers a spectacular view, its decoration in neutral tones conveys serenity. The convenience of having two bathrooms makes it unique. Ideal for travellers looking for peace of mind and functionality. Located just a few steps from Calle 50 and the iconic El Tornillo building. You're surrounded by casinos, hotels and restaurants. Safe area for walking and enjoying the city.

The Penthouse Annex
Inspired by Panama's rich history with France and located in one of the oldest watch towers in Panama, this chic apartment combines original features of this historically important building with the elegance and style of Europe. Perfectly situated to indulge in the restaurants, cafes, museums and boutique stores of Casco Viejo, and equipped with everything you expect from a home-from-home base, the annex is the perfect combination of comfort and style for couples and small groups of friends.

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO
The name of the Complex comes from the world-renowned architect and interior designer, Marcel Wanders. He had the idea to accentuate the flora and fauna of Panama and bring a relaxed sensation even though the complex is located in the middle of the city. This unit in particular has the most detailed pick on designer furniture from brands such as Herman Miller and Restoration Hardware. The kitchen is also fully equipped with Thermador appliances so you can live the Wanders & Yoo experience.

Tropicool Loft w/rooftop steps from Casco
This historic 1941 loft is located at the entrance of Casco Viejo where you’re steps from the fish market and all the cool cafés, rooftops, and trendy restaurants that make up the neighborhood. Fully equipped kitchen, washer/dryer combo, 1.5 bath, bedroom on 2nd floor, 2 balconies + communal rooftop, projector w/Netflix, fast internet, and great AC. You’re also directly in front of the Cinta Costera park for running, biking, tennis courts. Near local airport for flights to Bocas!

Cozy apartment near Casco Viejo
Enjoy a stay in one of the most exclusive areas in the center of Panama, few minutes from Casco Viejo the Cozy Apartment City Center offers free WiFi, air conditioning and stunning views amidst skyscrapers. The apartment has one bedroom with a queen-size bed, a bath and shower, a sofa bed, two smart TV, a fully equipped kitchen, a washer and dryer, and a half bath. On the property there is a work area, a gymnasium, a community pool, and a barbeque area FREE PARKING

Cozy apartment facing the sea.
This place is unique, it has its own style. Its location is strategic, it will be very easy to get there. It is located next to the Cinta Costera, near the metro station, Casco Antiguo, and all the tourist centers that Panama offers you. Come and enjoy this beautiful experience in one of Panama's finest buildings, offering tranquility, entertainment, gastronomy, cocktails, Panamanian history, and stunning views—all within the same building. Come visit us!

Escape to the Heart of Casco with a Private Balcony
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Modern and Central · Nice Condo in the Heart of Pty
¡Modern 50 m2 apartment located on Calle 50, in the heart of Panama City!. With access to the best in art, culture, business, finance, sports, shopping, food, and nightlife. * The space has a room with a queen size bed, full bathroom, smart TV and desk with monitor (HDMI cable) for those traveling without disconnecting from work. * The living room has a comfortable sofa bed, full bathroom, dining room and kitchen equipped for kitchen lovers!.

Beautiful Apartment 3 guests
Moderno, elegante y cómodo departamento, cerca de todo! Restaurantes, farmacias, supermercados, canchas de padle, a pocos minutos del centro comercial Multiplaza. Totalmente amoblado, 1 recamara, 1 baño completo, walking closet, cocina, sala, área de desayunador, lavadora-secadora y balcón. Para su disfrute, piscina de agua salada en el último piso, gimnasio, espacio de co-working, incluye un espacio de estacionamiento con valet parking.

Luxury apartment in downtown Panama, banking area
We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

King Bed, Creative Design Steps from Casco Viejo
Casco 114 is a stay created by travelers, for travelers. Located in the heart of Santa Ana, the creative district of Panama’s Casco viejo, it offers a king bed, full-size trundle, sofa bed, private terrace, washer/dryer, and unique decor. At PH Casco View: enjoy a saltwater pool, coworking space, stunning views of both the Old Town and the modern city, paid parking, and all the comforts for an unforgettable stay.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.
Popular amenities for Panama City holiday rentals
Other great holiday rentals in Panama City

A Modern & Cozy Apartment In Prime Location

Casco Viejo 2BR Loft • Rooftop Pool Gym & Balcony

Villas La Fontana Spacious ApartaSuite - Pool 102

YOO Panama · Luxury signature ocean view. 57th fl

VIP Suite/ Sea View + Pool & Sky Lounge + Gym

w* | Impeccable 1BR in Casco Viejo

On the beach. Entire floor with oceanfront terrace

Sea View in Panama City: BrisaMarina
Quick stats about holiday rentals in Panama City

Total holiday rentals
Explore 4,740 holiday rentals in Panama City

Nightly prices starting at
Panama City holiday rentals start at $15 AUD per night before taxes and fees

Verified guest reviews
Over 114,280 verified reviews to help you choose

Family-friendly holiday rentals
1,480 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 1,680 rentals that welcome pets

Holiday rentals with a pool
2,570 properties feature pools

Rentals with dedicated workspaces
2,880 properties have a dedicated workspace

Wi-Fi availability
4,490 of Panama City holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Gym, BBQ grill and Laptop-friendly workspace across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
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