Lake house accommodation & holiday rentals in Santee
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Top-rated lakehouse rentals in Santee
Guests agree: These lakehouses are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Santee lakehouse rentals
Waterfront lakehouse rentals
Home in Elloree
5.0 out of 5 average rating, 40 reviewsLake Front Property (Lake Marion)
24 Nov – 1 Dec
Home in Summerton
4.93 out of 5 average rating, 15 reviewsStanley's Lake House
20 – 27 Aug
Home in Santee
5.0 out of 5 average rating, 13 reviewsSantee Sanctuary ~ Lakefront
16 – 23 Dec
Home in Manning
4.9 out of 5 average rating, 21 reviewsCozy Church Branch Cabin
7 – 14 Jan
Home in Summerton
4.8 out of 5 average rating, 30 reviewsFamily friendly lakefront home with boat ramp
29 Dec – 5 Jan
Home in Summerton
4.93 out of 5 average rating, 30 reviewsCozy 3 bed 2 bath on the waterfront
7 – 14 Dec
Home in Summerton
5.0 out of 5 average rating, 10 reviewsThe Heron Lake House
1 – 8 Dec
Home in Branchville
4.93 out of 5 average rating, 30 reviewsEdisto River Turnhole Getaway
23 – 28 Aug
Pet-friendly lake house rentals
Home in Vance
4.74 out of 5 average rating, 68 reviewsLake Marion Getaway!
24 Nov – 1 Dec
Home in Elloree
4.92 out of 5 average rating, 25 reviewsLakehouse
15 – 22 Oct
Home in Summerton
4.8 out of 5 average rating, 15 reviewsSantee/Lizzie's Creek Lakefront
20 – 27 Oct
Home in Manning
4.88 out of 5 average rating, 34 reviewsJewel on the Lake
21 – 28 Apr
Home in Summerton
5.0 out of 5 average rating, 11 reviewsCarolina Cottagecore
18 – 25 Dec
Home in Ridgeville
5.0 out of 5 average rating, 17 reviewsRiverhouse Retreat on the Edisto River
18 – 25 Jan
Home in Swansea
4.97 out of 5 average rating, 33 reviewsSecluded lake house - 3 B.Room, 3 Bath - 3 Kayaks
27 May – 3 June
Home in Ridgeway
5.0 out of 5 average rating, 3 reviewsDamNiceView on Lake Wateree
21 – 28 Oct
Private lake house rentals
Home in Summerton
4.92 out of 5 average rating, 25 reviewsThe Fishnet
14 – 21 Feb
Home in Elloree
5.0 out of 5 average rating, 24 reviewsLured Away to our lakefront home
6 – 13 Aug
Home in Summerton
4.84 out of 5 average rating, 43 reviewsFlip Flop Inn (Short Walk To Boat Ramp & Kayaks!)
16 – 23 Dec
Home in Moncks Corner
4.97 out of 5 average rating, 64 reviewsLake Living
10 – 17 Sept
Home in Summerton
4.82 out of 5 average rating, 97 reviewsPerfect family vacation retreat at Lake Marion, SC
14 – 21 Apr
Home in Moncks Corner
4.95 out of 5 average rating, 37 reviewsCozy Little Nook
9 – 16 Jan
Home in Ridgeway
5.0 out of 5 average rating, 17 reviewsThe Little House
24 Nov – 1 Dec
Home in Chapin
4.97 out of 5 average rating, 63 reviewsLake Murray: Panoramic Views, Kayaks & Hot Tub
4 – 11 Dec
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