
House holiday rentals in Santee
Find and book unique houses on Airbnb
Top-rated house rentals in Santee
Guests agree: These houses are highly rated for location, cleanliness and more.

Tie One On! at 4 Bdr Waterfront Lake Marion
Relax, Recharge and "Tie One On" waterfront on Lake Marion! Welcome to your perfect lake escape! This cozy, pet-friendly retreat offers lovely wrap-around peninsular views, waterfront with a small dock, sunrooms, a spacious yard, and all the comforts of home. Enjoy mornings overlooking the water, afternoons kayaking or fishing, and evenings grilling & gazing at tranquil waters. Modern lake living! (Not on "big water" of Lake Marion but on amply sized arm of Lake Marion separated by causeway)

Lakefront w/ dock at Mill Creek
Nestled between Santee & Eutawville, Vance is less than an hour from Downtown Charleston. Experience lake life w/ a front row seat to live music, dancing & karaoke at the Mill Creek Marina! Float over to grab a bite or drink at the Barefoot Lakeside Bar & Mill Creek Food & Spirits! Community hosts golf cart parades, Halloween bash, & a spectacular 4th of July fireworks show. Launch your pontoon a few doors down, tie up at your dock & conveniently fuel up at the marina. Campground store on site!

The Grand Marshall
Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Lake House at Lake Marion
Beautiful lakefront 3 Bedrooms/2 full baths with million dollar view of Lake Marion. -2 Queen beds/2 twins/1 futon -Private Dock so you can fish in “big water” -Canoe and Kayak -Firepit -Includes linens and beach towels and more! -Fully Furnished + grill and covered parking -One level open concept -75” Roku TV & Roku in Master and WiFi -great safe neighborhood for walking and bike riding -NO HOUSE PARTIES or events. -public boat landing and county park with playground within 2 blocks.

Colonial Farmhouse - 6 bedroom with a pool
This private estate 4,355 s.f. (2,800 1st floor, 1,555 2nd floor) home was originally built around the year 1900 and features 6 bedrooms (3 upstairs, 3 downstairs) and 2.5 bathrooms (1.5 downstairs, 1 upstairs). It has 12 ft ceilings throughout, a large dining room, living room, and kitchen area, a beautiful foyer and large staircase, an office, laundry room, large porches, a fireplace, a carport, and a basketball court. You can conveniently walk on a paved walkway to the fenced pool area.

Your home away from home in Pinopolis
Nestled at the end of a quiet cul-de-sac, this house is close to Lake Moultrie & the Cooper River. It’s also very close to popular wedding venues: Somerset Point, Pineland Village, & Old Santee Canal Park. Moncks Corner Recreational Complex, where many tournaments are hosted, is also about 3 miles away. Pinopolis is less than 20 miles from Summerville & the Volvo area, 40 miles from coastal beaches, and just 45 minutes away from Downtown Charleston. It’s a great location for work or play!

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Stylish Lakefront Group Getaway Sleeps 8
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Perfect Family Retreat at Lake Marion
Great water front family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. We purchased our home is 2006 and began a complete interior and exterior renovation. In 2023 we installed solar panels and an electric vehicle charging station, yet we also have access to the grid for cloudy days and when power demand exceeds what our panels generate. We use a deep well for water. Bring your family for an off-the-grid vacation in our lake home!

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Nanny’s Lake Retreat
3 BR, 2 BA. Located in a quiet, dead end community. Enjoy the lake sounds from the spacious screened in porch. The porch has a swing, rocking chairs, and table with chairs. The den boasts a beautiful gas log fireplace and has two futons and a loveseat. The house is located in a golf cart community on a cove. Sandy beaches are just minutes away depending on the lake levels. Whether you’re looking for a vacation destination or fishing/hunting trip you will love this home.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.
Popular amenities for Santee house rentals
House rentals with a pool

The Sunset Chaser

Lakefront Farmhouse Retreat+Pool

Eagle Point Retreat W/Pool

Wyboo Retreat at Lake Marion W/Pool

Lakeview Leisure-Face to the Sun

Quiet Retreat:Secluded & Idyllic

The Merry Inn @ Lake Marion

Heated Indoor Pool on Lake Marion with Dock
Weekly house rentals

Rest and Relaxation

The Jolly Rancher

Eagle Point Sunset Retreat

Beautiful brick home w/ large porch and 3 bedrooms

The Wrenn’s Nest - Quaint National Forest Getaway

Cutest Cottage on the Lake

Golf and lake fun at Santee!

Spacious home with lake access on Lake Marion
Private house rentals

Relaxing Lake Getaway | Beautiful 3BR Home

Eagle Point Poolside Escape

The Branchville Estate

Prospect Point

Lake Moultrie retreat

No Cleaning Fee 3BR | Sleep 6 | Near Santee Lakes

Rural Country Getaway

Mark it Lake, Dude!
Quick stats about house rentals in Santee

Nightly prices starting at
Santee holiday rentals start at $140 AUD per night before taxes and fees

Verified guest reviews
Over 40 verified reviews to help you choose

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Santee rentals

4.9 Average rating
Santee stays are highly rated by guests—averaging 4.9 out of 5!
Destinations to explore
- Western North Carolina Holiday rentals
- Atlanta Holiday rentals
- Myrtle Beach Holiday rentals
- Charleston Holiday rentals
- Gatlinburg Holiday rentals
- Charlotte Holiday rentals
- Hilton Head Island Holiday rentals
- Savannah Holiday rentals
- Jacksonville Holiday rentals
- Cape Fear River Holiday rentals
- Pigeon Forge Holiday rentals
- North Myrtle Beach Holiday rentals
- Rentals with lake access Santee
- Rentals with a washing machine and dryer Santee
- Lakehouse rentals Santee
- Apartment rentals Santee
- Fitness-friendly rentals Santee
- Rentals with pools Santee
- Pet-friendly rentals Santee
- Family-friendly rentals Santee
- Rentals with a patio Santee
- House rentals Orangeburg County
- House rentals South Carolina
- House rentals United States
- Riverbanks Zoo and Garden
- University of South Carolina
- Middleton Place
- North Charleston Coliseum & Performing Arts Center
- Magnolia Plantation & Gardens
- Congaree National Park
- South Carolina State House
- Cypress Gardens
- Williams Brice Stadium
- Columbia Museum of Art
- South Carolina State Museum
- Colonial Life Arena
- West Columbia Riverwalk Park and Amphitheater
- Charleston Southern University
- Edventure
- Columbia Metropolitan Convention Center
- Sesquicentennial State Park
- Riverfront Park
- Wannamaker County Park
- Whirlin' Waters Adventure Waterpark
- Soda City Market
- Koger Center for the Arts
- Segra Park
- Bee City Zoo & Honey Bee Farm





