
House holiday rentals in Santee
Find and book unique houses on Airbnb
Top-rated house rentals in Santee
Guests agree: These houses are highly rated for location, cleanliness and more.

Panoramic Lakefront with Hot Tub
Welcome to 'Sunshine and Naptime' - This newly renovated home is located on the Chapin side of Lake Murray. The entire house is newly furnished and full of amenities. This 3 bedroom lakefront cottage sits on a point with 180 degree panoramic views. Vaulted rustic pine ceilings showcase the wall to wall windows for a view that will take your breath away. You can watch the sunrise AND sunset from the living room or 600 sq ft deck. There is a hot tub, 2 kayaks, shuffle board & private dock.

The Heart of Park Circle!
Nicely decorated home in trendy Park Circle, North Charleston. Park Circle is a shining example of a walkable community with a unique character that sets it apart. Within a few minutes walk you'll find the best restaurants and bars in town and plenty to do for any age. Check out my guidebook for a few local suggestions! Enjoy a game of disc golf, peaceful walk to the duck pond or the local farmer's market on Thursday afternoons. Come see why we've been called the Brooklyn of South Carolina!

Charming 3 bedroom bungalow
You’ll be close to everything when you stay at this centrally-located bungalow. You’re a 1 minute walk from beautiful Swan Lake Iris Gardens. Drive to downtown Sumter in 4 mins & Shaw AFB in 15 mins. Enjoy the cozy porch or outdoor fire pit with seating & basketball goal. There's a fenced yard for kids/pets. 3 bedrooms/1 bath; extra room with loveseat, TV, games/books/toys. Spacious kitchen & laundry room for your convenience. Enjoy free Wifi & Smart TVs. I am a licensed real estate agent.

Gorgeous 2 bed Farmhouse 15 mins from downtown
Forget your worries in this spacious and serene space. Our home welcomes you with 2 beds, 2 baths, a gorgeous fenced in yard, a screened in porch, and a beautiful fountain to calm your mind. All of your day to day conveniences are available in our home allowing you to settle in like it’s yours. Located 15 mins to downtown Summerville, 25 mins to downtown Charleston, and 30 mins to multiple beautiful beaches. For more space check out my other listing: https://www.airbnb.com/h/chucktowneapt

The Parkside Retreat
Welcome to our beautiful Airbnb! Located next to a serene and picturesque park, our home is perfect for families or groups looking for a comfortable stay. With two king master suites and a cozy kids room, we can accommodate up to 6 guests, making it an ideal choice for a family or a group getaway. Each master suite features a comfortable king-sized bed, plush linens, and ample storage space providing a tranquil retreat after a day of exploring the local attractions. Book your stay today!

Private home | 7 Acres Near Lake | Tucked away
The little house on Lincreek is tucked away down a hidden drive on 7 acres of beautiful wooded land with a creek, historic covered bridge and plenty of wildlife. Private one bedroom, one bath home with a full kitchen, breakfast nook, family room and spacious bedroom. Relax on the large front porch and enjoy being immersed in nature. The home is located less than 2 minutes from Lake Murray Dam. There is parking on site for a boat/trailer. 15 min to Columbia. *No smoking / No parties.

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Santee lakefront home, big water right off I-95
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Guest House/Villa
Enjoy your stay at this immaculately designed new build Villa. Located on a family property surrounded by 2 acres of trees, in a quiet rural neighborhood. Lots of privacy, peace and quiet, yet only 5 minutes from restaurants and stores. 15 minutes from Downtown Summerville, 40 minutes from Charleston and various coastal attractions. The villa is separate from main house and has no shared space other than the driveway. NO smoking, No pets. Laundry service available for long stays.

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Exceptional Heathwood Gem Near USC & Fort Jackson!
Perfectly situated in an upscale, quiet, tree-lined neighborhood, this hip 1940 classic renovated home is super-close to many of Columbia's classiest cafes, boutiques, USC campus, Fort Jackson, USC Law Center and other major attractions. It strikes just the right balance of location, peacefulness, style and comfort. Here, you can hang on the front porch to serenading birds and nearby church chimes or relax indoors with the 65" HDTV Surroundsound system and super-fast WiFi!

Little WeCo Cottage
Centrally located one bed one bath house. This 700 sqft house is perfect for a weekend getaway or a week working remote. Completely remodeled and ready for your next trip. Quiet street with only a couple of neighbors but still close to town. Within a 10 minute drive from the airport, downtown and 5-points - there really couldn't be a more prime location. Ft. Jackson is a quick 15 minute drive away too. Come stay at this cute cottage for your next trip to Cola.
Popular amenities for Santee house rentals
House rentals with a pool

Share-in Dipity Refined 4 bedrooms pool not heated

Colonial Farmhouse - 6 bedroom with a pool

Lavish Home 4BR/3BA, King, Games, Grill, Pool!

Park Circle Paradise - Pool, Putts & 3 King Suites

Gorgeous Executive Home on Pond *5 beds*

Family Friendly House in Charleston’s Park Circle

Retreat with Pool and Epic Game Room

Park Circle Tropical Oasis 3BR/2BA with Pool
Weekly house rentals

Lake House Retreat

Tie One On! at 4 Bdr Waterfront Lake Marion

Anchor Out Lake Marion

Lakefront w/ dock at Mill Creek

The Happy Sac 2

Lake House Getaway

Quiet 2BR Near Shaw AFB

Cottage at Camellia Cottages - charming & historic
Private house rentals

Rest and Relaxation

Lakefront home with boat ramp and game room

Lincoln Street Cozy Cottage!

Lakefront Fishing + Grilling | Home Sweet Home!

Theo's Place

Relaxing Lake Marion Home, near 3 boat landings

The Boho Barndo

The Indigo - 2BR w/Hot Tub & Outdoor Space
Quick stats about house rentals in Santee

Nightly prices starting at
Santee holiday rentals start at $141 AUD per night before taxes and fees

Verified guest reviews
Over 30 verified reviews to help you choose

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Santee rentals

4.9 Average rating
Santee stays are highly rated by guests—averaging 4.9 out of 5!
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- Riverbanks Zoo and Garden
- Middleton Place
- South Carolina State House
- Congaree National Park
- Columbia Museum of Art
- Magnolia Plantation & Gardens
- North Charleston Coliseum & Performing Arts Center
- South Carolina State Museum
- University of South Carolina
- Cypress Gardens
- Sesquicentennial State Park
- Edventure
- Charleston Southern University
- Colonial Life Arena
- Columbia Metropolitan Convention Center
- Soda City Market
- West Columbia Riverwalk Park and Amphitheater
- Riverfront Park
- Williams Brice Stadium
- Wannamaker County Park




