House holiday rentals in Santee

Lakefront w/ dock at Mill Creek

Nestled between Santee & Eutawville, Vance is less than an hour from Downtown Charleston. Experience lake life w/ a front row seat to live music, dancing & karaoke at the Mill Creek Marina! Float over to grab a bite or drink at the Barefoot Lakeside Bar & Mill Creek Food & Spirits! Community hosts golf cart parades, Halloween bash, & a spectacular 4th of July fireworks show. Launch your pontoon a few doors down, tie up at your dock & conveniently fuel up at the marina. Campground store on site!

The Grand Marshall

Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Heated Indoor Pool on Lake Marion with Dock

Lake Marion Lakefront on a private 2.5 acres. Two houses - 4500 sq. ft. of space, plenty of room for 14! Dock to fish off of or bring your fishing boat. Heated indoor pool and Margaritaville-themed bar. Firepit, pool table, games, and dining table for 14 people. Great spot for Family Gatherings or Friends' Getaway. Golf, fishing, fruit picking, and amazing country food restaurants - 25 min drive. 5% Discount Gov. Employees :) Parties over 14 ppl ++ fees apply, details discussed prior.

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Perfect Family Retreat at Lake Marion

Great water front family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. We purchased our home is 2006 and began a complete interior and exterior renovation. In 2023 we installed solar panels and an electric vehicle charging station, yet we also have access to the grid for cloudy days and when power demand exceeds what our panels generate. We use a deep well for water. Bring your family for an off-the-grid vacation in our lake home!

Fish Haven I

Looking for a quiet, yet charming lakeside property? Look no further! Come enjoy this three-bedroom home with direct access to the diversion canal and a private boat launch. Great space for fisherman, families or couples. Ample space for your boat and hitch. Enjoy your days fishing, savor your afternoon by having a beverage and grilling out on the back patio. Spend the evenings playing cornhole and relaxing by the fire pit. It is the perfect setting to create wonderful memories!

Pet-Friendly Lake Marion Getaway - Just off I-95!

In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Sunny Santee Stay · 5BR Cityview · Lake & Golf

Brand new 2025 modern, cozy home near interstate I95, golf courses, markets, local restaurants (Cracker Barrel Old Country Store, Starbucks, etc) and Lake Marion. Santee is right in the middle distance between Miami and New York. Clean and stylish space with two 75” smart TVs, Wi-Fi, full amenities, and easy self check-in. Relax with the whole family at this new clean, quiet, safe and peaceful neighborhood. View our profile to explore more homes in the area.

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Sunset Serenity Pool/Swim Spa

Experience next-level lakefront luxury in this brand-new 5BR/3BA custom home featuring a massive open-concept layout, chef’s kitchen, two master suites, and resort-style amenities like 20x40 infinity pool, swim spa, and fire pit. Enjoy a private dock, multiple lounge spaces, dual laundry sets, paddleboard/kayaks, and designer finishes throughout. Every detail of Sunset Serenity was designed for comfort, beauty, and unforgettable moments on Lake Marion.

Cypress shores cottage. Lake Marion Sc

Relax and recharge in this cozy 2BR/1BA home just one row back from Lake Marion. Enjoy an equipped kitchen, bright living area, large streaming TV, and private yard and outdoor seating. Slight water views add to the charm, with marinas, boat landings, and fishing spots just minutes away. Perfect for families, couples, anglers, small groups, or remote workers seeking a peaceful retreat in Eutawville and the Lowcountry.

Boogs Cabin at Lake Marion

Boogs Cabin at the Lake is your cozy, laid back getaway on the big water of Lake Marion. With three comfortable bedrooms (1 King 2 Queen), bonus game room that also has a pull-out full bed and two sleeping cots, large sliding glass doors in the living room that invite natural light in and offer views of the great outdoors it's the perfect place to play, recharge and reconnect.