
Holiday houses in Santee
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Top-rated holiday rentals in Santee
Guests agree: these stays are highly rated for location, cleanliness and more.

Fisherman's Dream at Low Falls Landing-Lake Marion
Don't Overlook this Waterfront Property! Fisherman's Dream on Lake Marion and Duck Hunter's Delight! Throw back from the 70's! Put in at Low Falls Landing & then tie on to the property's private dock. This is a 2 bdrm, 2 bth home. Screened porch w/swing & rocking chairs over looks waterfront. Open family rm & kitch. Gather w/friends & family. Large private dock w/ seating and rod holders. Lake Marion, largest lake in SC, catfish, crappy and brim fishing. Dogs welcome, No cats please.

Restful Lakeside Getaway Cottage -Dogs allowed
This pond-side cottage is a peaceful place to relax and unwind. Sit on the enclosed porch and watch the water or enjoy the front porch swing where you can listen to the birds and frogs. We are 12 min. from downtown Sumter and 20 min from Shaw AFB. Local points of interest are Swan Lake Iris Gardens and Poinsett State Park. It is only 2 hours to Myrtle Beach and Charleston, SC & 3 hrs to the mtns. While it is conveniently located, this cottage offers a quiet place to put your feet up and rest.

Lakefront w/ dock at Mill Creek
Nestled between Santee & Eutawville, Vance is less than an hour from Downtown Charleston. Experience lake life w/ a front row seat to live music, dancing & karaoke at the Mill Creek Marina! Float over to grab a bite or drink at the Barefoot Lakeside Bar & Mill Creek Food & Spirits! Community hosts golf cart parades, Halloween bash, & a spectacular 4th of July fireworks show. Launch your pontoon a few doors down, tie up at your dock & conveniently fuel up at the marina. Campground store on site!

Cozy Church Branch Cabin
A cozy lakefront cottage made by family, for family. This was our parents home away from home, their favorite getaway. Now that they're gone, we want to share what they enjoyed. Traditionally constructed lake cabin with all the comforts of home. Large partially covered deck, large pier for fishing, plenty of room to bring your boat, canoes, or kayaks. Extremely close proximity to large landings where national fishing tournaments are held on Lake Marion. Prime hunting, near great hunting clubs.

Log home on Lake Marion inlet w/private dock.
Relax with family and friends at this peaceful lake home. Located on an inlet one minute off the largest lake in South Carolina, Lake Marion is known for it's big fish and abundant wildlife. With your own private dock, you can boat/fish all day and leave your boat in the water for your entire stay. If you enjoy golfing, three of the states best golf courses are within minutes. This log home is centrally located between Columbia and Charleston. Restaurants, shopping, and beaches all close by.

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Santee lakefront home, big water right off I-95
Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

Nanny’s Lake Retreat
3 BR, 2 BA. Located in a quiet, dead end community. Enjoy the lake sounds from the spacious screened in porch. The porch has a swing, rocking chairs, and table with chairs. The den boasts a beautiful gas log fireplace and has two futons and a loveseat. The house is located in a golf cart community on a cove. Sandy beaches are just minutes away depending on the lake levels. Whether you’re looking for a vacation destination or fishing/hunting trip you will love this home.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Sunset Serenity Pool/Swim Spa
Experience next-level lakefront luxury in this brand-new 5BR/3BA custom home featuring a massive open-concept layout, chef’s kitchen, two master suites, and resort-style amenities like 20x40 infinity pool, swim spa, and fire pit. Enjoy a private dock, multiple lounge spaces, dual laundry sets, paddleboard/kayaks, and designer finishes throughout. Every detail of Sunset Serenity was designed for comfort, beauty, and unforgettable moments on Lake Marion.

Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss
Introducing your lakeside sanctuary at Lake Marion! This carefully renovated 2 BR, 2 BA condo boasts sweeping lake vistas, fresh LVP flooring, modern lighting, and charming accent walls. Delight in lakeside grilling or venture out for aquatic fun with direct lake access. An hour away from Charleston and Columbia, surrounded by shopping, dining, and golf options, this retreat offers the best of relaxation and adventure.
Popular amenities for Santee holiday rentals
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Welcome to the Beehive.
When is the best time to visit Santee?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | $329 AUD | $341 AUD | $359 AUD | $358 AUD | $352 AUD | $390 AUD | $331 AUD | $391 AUD | $404 AUD | $410 AUD | $390 AUD | $401 AUD |
| Avg. temp | 10°C | 12°C | 15°C | 19°C | 23°C | 26°C | 28°C | 27°C | 25°C | 20°C | 15°C | 11°C |
Frequently Asked Questions
Are there vacation rentals with a dedicated workspace in Santee?
Yes! Work meets play with ease at over 10 vacation rentals in Santee featuring dedicated workspaces. Stay connected and productive in your home away from home.
Are there Santee vacation rentals on Airbnb with pools?
Yes! Dive into the perfect getaway at one of over 20 vacation homes with pools in Santee, available on Airbnb. Make a splash and soak up the sun in style!
How much does it cost to stay in apartment rentals in Santee?
Experience the best of Santee with our apartment rentals, starting at about $150 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Do apartment rentals in Santee have wifi?
Absolutely! We offer over 10 apartment rentals with wifi in Santee. Enjoy a tailored experience with all the comforts you desire.
Do apartment rentals in Santee have a gym?
Absolutely! We offer over 10 apartment rentals with a gym in Santee. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly vacation rentals in Santee?
Santee has more than 30 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.
Quick stats about holiday rentals in Santee

Total holiday rentals
Explore 30 holiday rentals in Santee

Nightly prices starting at
Santee holiday rentals start at $141 AUD per night before taxes and fees

Verified guest reviews
Over 220 verified reviews to help you choose

Family-friendly holiday rentals
30 properties offer extra space and kid-friendly amenities

Holiday rentals with a pool
20 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
30 of Santee holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Self check-in, Gym and BBQ grill across Santee rentals

4.8 Average rating
Santee stays are highly rated by guests—averaging 4.8 out of 5!
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- Riverbanks Zoo and Garden
- Middleton Place
- Magnolia Plantation & Gardens
- Congaree National Park
- South Carolina State House
- Columbia Museum of Art
- University of South Carolina
- Cypress Gardens
- South Carolina State Museum
- West Columbia Riverwalk Park and Amphitheater
- Colonial Life Arena
- Columbia Metropolitan Convention Center
- Williams Brice Stadium
- Sesquicentennial State Park
- Charleston Southern University
- Edventure
- Soda City Market
- Wannamaker County Park
- Riverfront Park
- North Charleston Coliseum & Performing Arts Center




