
House holiday rentals in Upstate South Carolina
Find and book unique houses on Airbnb
Top-rated house rentals in Upstate South Carolina
Guests agree: These houses are highly rated for location, cleanliness and more.

Lake Front/firepit/kayaks/ game room & pool table
Welcome to our sweet lake retreat! Relax with the whole family in our peaceful lakefront home. This is a newer construction home with custom upgrades and sleeps up to 14 people. This is in the BEST location on Lake Greenwood! We are located on the main water and close to Harris landing, Twin rivers, Break on the lake, and the 'sandbar'. Enjoy your morning coffee or evening cocktails on our peaceful porch and watch all the wildlife this lake offers. We would love to have you (NO EVENTS/PARTIES!)

Atrium House - Spa Retreat
Come unwind and breathe at our couples mountain spa retreat. Atrium House has been designed to feel open to the lovely mountain surroundings yet let you relax in privacy. Our outdoor therapy hot tub, indoor/outdoor gas fireplace, and spacious two-person, walk-in shower make for a getaway so tranquil, you may never make it in to nearby Asheville! We're out in the country but just over a 15-minute drive from downtown Asheville, Biltmore, Hendersonville, Asheville Airport, and dozens of breweries.

Luxury Retreat & Heated Pool Downtown Simpsonville
Luxury Pool House in the Heart of Simpsonville – Perfect for Gatherings! Designed for comfort, fun, and relaxation. 2 minutes from Downtown Simpsonville and 15 minutes from Downtown Greenville, this luxury retreat feels like a private resort with all the warmth of home. With nature views and countless amenities, you’ll have everything you need for an unforgettable stay. Up to 8 guests with 4 Spacious Beds and 2.5 Baths. Indoor & Outdoor Entertainment, Well-Equipped Kitchen, Cozy Living Room!

Luxurious 3BR on Lake Saluda w/ Kayaks, Fire Pit
Welcome to Lake Saluda Serenity, your tranquil lake house retreat just 15 minutes from Downtown Greenville! This stylish 3BR, 2BA haven combines modern aesthetics with breathtaking natural views. Revel in tranquility on the spacious patio or delve into adventures with provided kayaks and pedal boats. Explore lake life at your pace and soak in the serene surroundings. Nestled in an idyllic locale with top-notch amenities, it's your quintessential escape to lakefront luxury and modern comfort.

Riverfront-10 min Dwtn Gvl-HotTub-GameRm-Sleeps 13
Greenville's riverfront- Sleeps 13 on the Saluda River! This riverfront escape is 10 min to downtown Greenville, 30 min to Clemson, and packed with fun! Enjoy 2 master suites, a bunk room, game room (pool table, arcade, karaoke), hot tub, Sauna, cold plunge firepit, outdoor kitchen, movie screen, kayaks, and more. Close to Falls Park, PKL Pickleball, Paris Mountain & dining. Perfect for families, groups & game-day stays. Launch kayaks right from your home. Book now for the ultimate getaway!

Clemson Lake Hartwell Waterfront, Pontoon Rental
Come and enjoy a relaxing family vacation on beautiful Lake Hartwell in this spacious 2 level home. Plenty of room for multiple families to share. This 7600 sq. ft lakefront home sleep up to 18 featuring 7 bedrooms with 1 additional rooms with sofa beds; 5 full-sized bathrooms; 1 laundry area with 2 washers & 2 dryers. Each level boasts a fully furnished kitchen along with a large entertainment area. Breakfast area off main kitchen in addition to a spacious dining room that seats up to 10.

Huge Views, Outdoor Tub, Fire Pit, Close to Town!
Perched at 4,200' high and under 10 minutes to downtown Highlands and Cashiers, this easily accessed, light filled, cabin offers massive, year-round, long range views of Whiteside &Rock Mountains from every room of the house as well as from our expansive decks! -10 Minutes to Downtown Highlands (shopping, dining, art culture) -8 Minutes to Cashiers Crossroads (Whiteside brewery, coffee, shopping) -5 Minutes to Whiteside Mountain trailhead -15 Minutes to Lake Glenville (Boat Rentals!)

Cabin I Private hiking trails | Hot Tub I Sauna
Welcome to your private mountain escape in Lake Toxaway, NC! This 1-bedroom, 2-bathroom cabin is a one-of-a-kind retreat, offering breathtaking sunset views, a peaceful wooded setting, and unique architectural details. Unwind in the hot tub under the stars, relax in the sauna, challenge your partner to air hockey, or cozy up by the fire pit—all while enjoying the beauty of nature. Plus, enjoy exclusive access to 3 miles of private hiking trails, perfect for exploring the great outdoors!

Orchard Hill Vintage Cottage
Come enjoy this magnificent view in Saluda! Relax in the swings or sit on the porch and enjoy the peacefulness. The fire pit under the stars is so Saludacrous! Our cozy cottage is just steps from Judds Peak and 2 miles from downtown, where there is always food and fun! The Gorge Zipline is located in our quaint little town and the Green River has hiking, tubing, kayaking, white water rafting, rock climbing! The towns of Hendersonville, Flat Rock and Asheville are just minutes away.

Waterfall Views, Lake Hartwell, Highland Architect
Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

The Dogwoods Upper at Vineyard Gap
Welcome to the Upper Dogwoods of Vineyard Gap, our Upper Unit offers panoramic views of mountains and forest, perfect for a serene escape. This handcrafted retreat features expansive windows that bring nature’s beauty inside, creating a secluded haven for couples or solo adventurers. If you’re traveling with friends or family, reach out about booking our two other unique units for a full experience. Enjoy the best view in The Dogwoods from this breathtaking vantage point!

Cozy Treehouse
Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.
Popular amenities for Upstate South Carolina house rentals
House rentals with a pool

Pool Gameroom Hot Tub Family Fun Getaway

Maggie's Lake House

Palmetto Escape -Family Friendly base 6.6 mi GVL

Shalom House with Pool near DT Greer SC

Spacious 3 BR house with private backyard.

10 minutes to downtown. Hot tub & billard room

NEW - Heated Pool - Hot Tub - Game Room - Sauna -

Lake house w/ a pool and Pickleball court
Weekly house rentals

Pettigru House: A Historic Boutique Stay Downtown

Fairview Luxury Oasis

Amazing Lakefront home with private NEW dock

Cozy home in downtown TR

Cozy Lakefront 2 bedroom with pool table

Pumpkintown Mountain View Cottage

Modern Lake Vibes – Kayaks, Dock & Fireplace

Plumfield
Private house rentals

Luxury Treehouse Retreat | Private Trails & Views!

Lakefront Private Cove with Boat/Jet Ski Options

Altamont Rest-Top of the Mtn Luxury Adult Retreat

Serenity On Broadway Lake

Welcome to River House

Modern Cottage in the Woods w/Hot Tub & Firepit

Tekoa at Table Rock

Modern Mountain Stream Overlook
Destinations to explore
- Nashville Holiday rentals
- Atlanta Holiday rentals
- Myrtle Beach Holiday rentals
- Charlotte Holiday rentals
- Gatlinburg Holiday rentals
- Savannah Holiday rentals
- Pigeon Forge Holiday rentals
- Charleston Holiday rentals
- Hilton Head Island Holiday rentals
- North Myrtle Beach Holiday rentals
- Asheville Holiday rentals
- Raleigh Holiday rentals
- Rentals with a sauna Upstate South Carolina
- Tiny house rentals Upstate South Carolina
- Villa rentals Upstate South Carolina
- Rentals with beach access Upstate South Carolina
- Nature eco lodge rentals Upstate South Carolina
- Townhouse rentals Upstate South Carolina
- Chalet rentals Upstate South Carolina
- Rentals with breakfast Upstate South Carolina
- Private suite rentals Upstate South Carolina
- Waterfront rentals Upstate South Carolina
- Tree house rentals Upstate South Carolina
- Apartment rentals Upstate South Carolina
- Rentals with an accessible height toilet Upstate South Carolina
- Rentals with a kayak Upstate South Carolina
- Rentals with a hot tub Upstate South Carolina
- Barn rentals Upstate South Carolina
- Rentals with pools Upstate South Carolina
- Ski-in/ski-out rentals Upstate South Carolina
- Hotel rooms Upstate South Carolina
- Luxury rentals Upstate South Carolina
- Serviced apartment rentals Upstate South Carolina
- Holiday home rentals Upstate South Carolina
- Beachfront rentals Upstate South Carolina
- Condo rentals Upstate South Carolina
- Resort rentals Upstate South Carolina
- Tent rentals Upstate South Carolina
- Family-friendly rentals Upstate South Carolina
- Boutique hotels Upstate South Carolina
- Dome rentals Upstate South Carolina
- Cottage rentals Upstate South Carolina
- Pet-friendly rentals Upstate South Carolina
- Campsite rentals Upstate South Carolina
- Guesthouse rentals Upstate South Carolina
- Rentals with lake access Upstate South Carolina
- Farmstay rentals Upstate South Carolina
- RV rentals Upstate South Carolina
- Cabin rentals Upstate South Carolina
- Loft rentals Upstate South Carolina
- Bed and breakfasts Upstate South Carolina
- House rentals South Carolina
- House rentals United States
- Clemson University
- Blue Ridge Parkway
- Tryon International Equestrian Center
- Table Rock State Park
- The North Carolina Arboretum
- Chimney Rock State Park
- Gorges State Park
- Devils Fork State Park
- Lake Lure Beach and Water Park
- DuPont State Forest
- Bon Secours Wellness Arena
- Saint Paul Mountain Vineyards
- Jump Off Rock
- Fred W Symmes Chapel
- Fluor Field at the West End
- Jones Gap State Park
- Falls Park On The Reedy
- Peace Center
- Carl Sandburg Home National Historic Site
- Overmountain Vineyards
- Whitewater Falls
- Oconee State Park
- Furman University
- Memorial Stadium, Clemson
- Things to do Upstate South Carolina
- Art workshops Upstate South Carolina
- Things to do South Carolina
- Cooking South Carolina
- Wildlife South Carolina
- Food tours South Carolina
- Cultural tours South Carolina
- Outdoors South Carolina
- Landmarks South Carolina
- Tastings South Carolina
- Art workshops South Carolina
- Water sports South Carolina
- Things to do United States
- Dining United States
- Museums United States
- Shopping and fashion United States
- Cultural tours United States
- Architecture United States
- Workouts United States
- Art workshops United States
- Flying United States
- Wellness United States
- Food tours United States
- Wildlife United States
- Water sports United States
- Landmarks United States
- Performances United States
- Tastings United States
- Galleries United States
- Cooking United States
- Beauty United States
- Outdoors United States





