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House holiday rentals in Upstate South Carolina

Find and book unique houses on Airbnb

Top-rated house rentals in Upstate South Carolina

Guests agree: These houses are highly rated for location, cleanliness and more.

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Top Guest favourite
Home in Travelers Rest
5.0 out of 5 average rating, 184 reviews

Modern Wooded Retreat

Come relax with the whole family in a place you'll never want to leave! Just 5 min. to downtown TR, and less than 20 min to downtown Greenville! Watch movies under the stars, roast marshmallows by the firepit, play cornhole and giant sized yard games in the fully fenced, dog friendly back yard. Close to the swamp rabbit trail, and centrally located to lakes, hiking, fishing and exciting nightlife. We'd love to host you, while you explore everything Greenville and Travelers Rest have to offer.

Guest favourite
The outdoor area showcases a tranquil pool surrounded by lush greenery, with comfortable lounge chairs positioned nearby. A pastel sunset provides a serene backdrop, while inflatable pool accessories add a playful touch to the inviting atmosphere.
Home in Simpsonville
4.93 out of 5 average rating, 108 reviews

Luxury Retreat & Heated Pool Downtown Simpsonville

Luxury Pool House in the Heart of Simpsonville – Perfect for Gatherings! Designed for comfort, fun, and relaxation. 2 minutes from Downtown Simpsonville and 15 minutes from Downtown Greenville, this luxury retreat feels like a private resort with all the warmth of home. With nature views and countless amenities, you’ll have everything you need for an unforgettable stay. Up to 8 guests with 4 Spacious Beds and 2.5 Baths. Indoor & Outdoor Entertainment, Well-Equipped Kitchen, Cozy Living Room!

Top Guest favourite
A spacious covered patio area features modern outdoor seating, with a view of the lake framed by large glass doors. Soft string lights hang overhead, enhancing the serene atmosphere. A cozy fire pit table offers an inviting focal point for gatherings.
Home in Easley
4.99 out of 5 average rating, 106 reviews

Luxurious 3BR on Lake Saluda w/ Kayaks, Fire Pit

Welcome to Lake Saluda Serenity, your tranquil lake house retreat just 15 minutes from Downtown Greenville! This stylish 3BR, 2BA haven combines modern aesthetics with breathtaking natural views. Revel in tranquility on the spacious patio or delve into adventures with provided kayaks and pedal boats. Explore lake life at your pace and soak in the serene surroundings. Nestled in an idyllic locale with top-notch amenities, it's your quintessential escape to lakefront luxury and modern comfort.

Top Guest favourite
An aerial view of a spacious two-level brick home is presented, showcasing a large parking area in front with two garage doors visible. Surrounding greenery enhances the setting, while the property is bordered by trees, providing a sense of privacy.
Home in Anderson
4.95 out of 5 average rating, 146 reviews

Clemson Lake Hartwell Waterfront, Pontoon Rental

Come and enjoy a relaxing family vacation on beautiful Lake Hartwell in this spacious 2 level home. Plenty of room for multiple families to share. This 7600 sq. ft lakefront home sleep up to 18 featuring 7 bedrooms with 1 additional rooms with sofa beds; 5 full-sized bathrooms; 1 laundry area with 2 washers & 2 dryers. Each level boasts a fully furnished kitchen along with a large entertainment area. Breakfast area off main kitchen in addition to a spacious dining room that seats up to 10.

Guest favourite
Home in Six Mile
4.84 out of 5 average rating, 281 reviews

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

Guest favourite
A spacious outdoor living area features a comfy sectional sofa and a wooden coffee table, surrounded by lush greenery. Two hanging chairs provide a relaxing spot to enjoy the expansive mountain views, while a hammock stretches across the deck, inviting tranquil moments.
Home in Highlands
4.92 out of 5 average rating, 107 reviews

Huge Views, Outdoor Tub, Fire Pit, Close to Town!

Perched at 4,200' high and under 10 minutes to downtown Highlands and Cashiers, this easily accessed, light filled, cabin offers massive, year-round, long range views of Whiteside &Rock Mountains from every room of the house as well as from our expansive decks! -10 Minutes to Downtown Highlands (shopping, dining, art culture) -8 Minutes to Cashiers Crossroads (Whiteside brewery, coffee, shopping) -5 Minutes to Whiteside Mountain trailhead -15 Minutes to Lake Glenville (Boat Rentals!)

Top Guest favourite
Home in Lake Toxaway
4.99 out of 5 average rating, 380 reviews

Cabin I Private hiking trails | Hot Tub I Sauna

Welcome to your private mountain escape in Lake Toxaway, NC! This 1-bedroom, 2-bathroom cabin is a one-of-a-kind retreat, offering breathtaking sunset views, a peaceful wooded setting, and unique architectural details. Unwind in the hot tub under the stars, relax in the sauna, challenge your partner to air hockey, or cozy up by the fire pit—all while enjoying the beauty of nature. Plus, enjoy exclusive access to 3 miles of private hiking trails, perfect for exploring the great outdoors!

Top Guest favourite
A spacious living area is illuminated by natural light, featuring large windows with scenic mountain views. Soft, neutral-colored seating is arranged for comfort, including a cozy sectional sofa and armchairs. Decorative curtains frame the windows, enhancing the inviting atmosphere.
Home in Saluda
4.99 out of 5 average rating, 155 reviews

Orchard Hill Vintage Cottage

Come enjoy this magnificent view in Saluda! Relax in the swings or sit on the porch and enjoy the peacefulness. The fire pit under the stars is so Saludacrous! Our cozy cottage is just steps from Judds Peak and 2 miles from downtown, where there is always food and fun! The Gorge Zipline is located in our quaint little town and the Green River has hiking, tubing, kayaking, white water rafting, rock climbing! The towns of Hendersonville, Flat Rock and Asheville are just minutes away.

Guest favourite
Home in Westminster
4.94 out of 5 average rating, 302 reviews

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Top Guest favourite
A cottage is shown with a large front porch, offering a relaxed outdoor seating area. The building features a modern design with large windows, surrounded by lush greenery. The porch is equipped with ceiling fans, creating a comfortable atmosphere.
Home in Pickens
5.0 out of 5 average rating, 104 reviews

Pumpkintown Mountain View Cottage

Welcome to Pumpkintown Mountain view Cottage, a 2 bedroom with 1 bath with a large porch and great views of Table Rock and Caesar's Head ridge line. Great location to stay for year-round outdoor activities from hiking (5 miles to Table Rock State Park) to swimming and festivals. We are located 20 minutes to Easley, City of Pickens and Travelers rest. This place has a mix of country, farm and Mountain life in one location so come and relax after a good day of outdoor activities.

Top Guest favourite
The treehouse structure features a distinctive A-frame design with large glass paneling allowing for abundant natural light. Surrounded by trees, an outdoor deck with seating complements the lush woodland setting. The rooftop deck above adds to the unique architectural appeal.
Home in Greenville
4.99 out of 5 average rating, 275 reviews

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Top Guest favourite
The exterior showcases a striking multi-level mountain villa framed by lush trees. A spacious deck with loungers is visible, complemented by elegant outdoor lighting. The modern architecture features large windows that invite natural light, enhancing the connection with the scenic surroundings.
Home in Greenville
4.94 out of 5 average rating, 102 reviews

Mountain Villa 15min from Downtown Greenville

You'll love the unbelievable sunsets from this one-of-a-kind mountain villa that's just an easy 15 minute drive from downtown Greenville. With sweeping mountain views and luxurious finishes, this home will wow you from every room. The main level has a huge 8x12 accordion door that leads out to the soaring deck with glass rails, perfect for enjoying the sunsets. Elegantly designed, each room of this house is an experience and perfect for your stay.

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