Guesthouse holiday rentals in Upstate South Carolina

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Upstate South Carolina guesthouses

Family-Friendly guesthouses

Top Guest favourite
Guesthouse in Greer
4.94 out of 5 average rating, 286 reviews

Executive Suite on a farm @GSP Airport

TiffanyRating, 5 stars1 day ago
This was by far our favorite!!! This home is absolutely lovely! Decorated so well, cozy and inviting and the bed very comfy! The grounds are gorgeous! Honestly I can’t say enough the only problem we had was not getting to spend enough time there to really enjoy it as we were there for work :( However would most definitely book again! Joey is a fabulous host and always so responsive! THANK YOU!!!
Top Guest favourite
Guesthouse in Swannanoa
4.98 out of 5 average rating, 656 reviews

Bramble Cottage: 10 min from Asheville & Blk Mtn

SheilaRating, 5 stars3 days ago
Jenny’s guest house was exactly just what I needed to decompress and relax. I was welcomed with some fruit and a muffin. Place was clean with everything that I needed. My favorite part was the back porch. Read, ate dinners and sipped wine there. Can’t wait to go back!!!
Top Guest favourite
Guesthouse in Donalds
4.99 out of 5 average rating, 377 reviews

Home on the farm

PeggysueRating, 5 stars2 weeks ago
This was our 3rd time there. It is the most relaxing place to stay. Ruth thinks of everything, you don’t want for anything. You will not find any better hosts than Ruth and Bob. We absolutely love our stays, have stayed in both the apartment and the cabin and we’ve been extremely happy in both. If we could live there we would! I highly recommend staying in either place. Ruth is the sweetest person you will ever meet and makes you feel like family.
Superhost
Guesthouse in Leicester
4.9 out of 5 average rating, 335 reviews

Relax by the creek. 10 Min. to West Asheville

AbbyRating, 5 stars1 week ago
I had a great stay here! The place had everything that I needed. There was great wifi access and I was able to work here. The area was beautiful and I woke up to birds every morning. James was friendly and an all around great host. I’d highly recommend to anyone coming to the Asheville area. I hope to visit again!
Top Guest favourite
Guesthouse in Avery Creek
4.99 out of 5 average rating, 318 reviews

Loft in the Countryside

MichelleRating, 5 stars3 weeks ago
It’s such a calm place. I enjoyed sitting on the couch each morning, drinking coffee and watching the horses across the way. The coffee the hosts provided was delicious. The bed was very comfortable. The hosts were welcoming, their old dog was very sweet, and the few glimpses and sounds of an active and loving family made me nostalgic for old times, when my children were young.
Top Guest favourite
Guesthouse in Tryon
4.98 out of 5 average rating, 110 reviews

Historic Jockey Cottage, TIEC 20 mins, Tryon 5

CourtenayRating, 5 stars3 weeks ago
I’m selfishly not wanting to write this great review because I will be sad if the place is booked when I go back to Tryon! The place was perfect for my pup and I while showing at TIEC. The hosts are lovely, and the place stocked with a coffee bar and water, and the community itself is beautiful. Quiet, peaceful, yet super convenient for restaurants and shopping. I will be back! Also, apologies. I stole your box of tissue under the bathroom sink because my allergies were killing me at the horse show: I meant to replace it with one I night but I forgot this morning. I apologize again and thank you!
Top Guest favourite
Guesthouse in Swannanoa
4.98 out of 5 average rating, 359 reviews

Buckeye Studio-between Asheville and Black Mtn.

LoraRating, 5 stars1 month ago
If I could live here for the rest of my life, I would. Judy and Steve are wonderful hosts who happen to be living on a slice of perfection. The space is large, squeaky clean, quiet, and I hadn’t slept as well in years. Perfectly appointed. Parking is right outside in their large driveway with a dedicated spot. I chose to walk in the evenings and saw horses, sheep, goats, and a very friendly donkey next door. The best rental space I have ever stayed in which has been numerous. Thank you for sharing, Judy and Steve.
Top Guest favourite
Guesthouse in Fairview
4.98 out of 5 average rating, 696 reviews

Modern Loft in the Mountains

KevinRating, 5 stars1 week ago
Great place in the mountains! Easy drive to the Blue Ridge Parkway and Asheville. The space looked bigger in person than it does in the photos with great natural light. Angie gave very detailed driving directions for check-in. It was perfect for me and my two kids while passing through.

Guesthouses with a patio

Top Guest favourite
Guesthouse in Ashville
4.97 out of 5 average rating, 186 reviews

Firefly Cove Guesthouse

Megan And D.J.Rating, 5 stars1 week ago
Such a beautiful, peaceful gem of a stay. Erin and Rob (and their friends) are lovely—generous, kind, warm. And they’ve cultivated a true home away from home. Can’t recommend enough!
Top Guest favourite
Guesthouse in Campobello
4.97 out of 5 average rating, 120 reviews

Bungalow on a 3 acre mini farm

GalinaRating, 5 stars3 weeks ago
We were visiting family in SC and wanted a quite place to stay at. And this place definitely delivered. Even though it is small, it had everything we needed. We enjoyed the beautiful garden, the peaceful upstairs and a sweet surprise from a bear, the last day we were there! The place is very clean and had the essentials. Thank you the memories!
Top Guest favourite
Guesthouse in Hendersonville
4.97 out of 5 average rating, 104 reviews

Modern Studio near downtown

TimRating, 5 stars2 days ago
Great place to stay, centrally located to get out and explore the area.
Guest favourite
Guesthouse in Candler
4.96 out of 5 average rating, 106 reviews

Yes please we need you! Spacious w/ amazing view!

JocelynRating, 5 stars1 month ago
The view was amazing! Our favorite place was sitting by the fireplace. It looked just like the pictures. Quiet and peaceful. Nice touches with the decor. Anglea responded and answered questions quickly. It's approximately 15 - 20 minutes from Asheville. 10/10 would recommend.
Top Guest favourite
Guesthouse in Maggie Valley
4.96 out of 5 average rating, 128 reviews

Spectacular Great Smokey Mountains Views

Christian AlexanderRating, 5 stars2 weeks ago
Wonderful hosts, my wife and I spent the weekend at The Nest and loved every minute of it. Greg and Gayle were incredibly welcoming and friendly. Very easy to gain entry upon arrival and the place was spotless. Would very much recommend for a weekend getaway or a “mini-moon.”
Top Guest favourite
Guesthouse in Bishop
4.99 out of 5 average rating, 140 reviews

The Nest, Charming Country Setting south of Athens

TylerRating, 5 stars3 weeks ago
As always, this place is fantastic. The surroundings are so peaceful and it's a great place to relax away from it all. The hosts are also some of the best I've ever had.
Top Guest favourite
Guesthouse in Maggie Valley
4.99 out of 5 average rating, 356 reviews

Starswept Studio–Walk to Brewery, Near BRP & GSMNP

JoanRating, 5 stars1 week ago
Nancy’s place was beautiful and serene. Accommodations were comfortable and quaint, and worth the price. Nancy responds quickly to questions, and makes you feel right at home.
Guest favourite
Guesthouse in Travelers Rest
4.97 out of 5 average rating, 124 reviews

Modern guesthouse in downtown TR

RonRating, 5 stars2 weeks ago
Fun little space! Great kitchen for a tiny home if you like to cook. Only trouble coming with lots of food to prepare is there are so many restaurants, EXCELLENT restaurants, just a few blocks away. I strongly recommend "TOPSOIL"! I enjoyed my privacy and found it so easy to get on the road and go any direction.

Guest house rentals with a washing machine and dryer

Guest favourite
Guesthouse in Greenville
4.98 out of 5 average rating, 104 reviews

The Spring Valley Retreat

CoraleeRating, 5 stars2 weeks ago
We had a lovely stay and was a great place to host our adult kids for family dinner and games. It was comfortable for our downtime. We would stay again when we visit. Peter, the cat, was a welcome visitor!
Guest favourite
Guesthouse in Fountain Inn
4.97 out of 5 average rating, 102 reviews

Upscale cottage in Downtown Fountain Inn

DanielRating, 5 stars1 month ago
Loved staying here! Check in was super easy and everything was very clean. Thank you!
Top Guest favourite
Guesthouse in Pendergrass
4.97 out of 5 average rating, 405 reviews

Peaceful Guesthouse on 15 Acres with Pool

CherylRating, 5 stars3 weeks ago
I have stayed at many Airbnb’s, but this might be my favorite. Not only was it so peaceful, roomy, and priced reasonably, but the salt water pool was the icing on the cake for this swimmer! And the hosts were so kind to help me in and out with my luggage and even sprayed my car off before I departed!
Top Guest favourite
Guesthouse in Westminster
4.99 out of 5 average rating, 178 reviews

Lit'l Bit O' Heaven- Rocky Top Lodge

JimmyRating, 5 stars1 week ago
this lil cabin is amazing. kitchen well stocked, beautiful patio. even the fire pit was setup, ready to light it up. great breakfast selection. I highly recommend this cabin
Top Guest favourite
Guesthouse in Greenville
4.94 out of 5 average rating, 206 reviews

Gorgeous Downtown Studio & Dog Friendly!

AngieRating, 5 stars1 month ago
Sarah's Airbnb is awesome! It is so beautiful, and in a great location. She left great recommendations for things to do, and places to eat. Thank you for sharing you special place with us!!
Guest favourite
Guesthouse in Whittier
4.94 out of 5 average rating, 257 reviews

Nature's Nest

ResseRating, 5 stars1 week ago
Nature’s Nest was an absolute gem! The space was cozy, impeccably clean, and packed with thoughtful touches that made our stay feel like a home away from home. The location was perfect for exploring the area, and Darlene was incredibly responsive, providing helpful local tips that made our trip unforgettable. The bed was super comfortable, and the charming decor gave the place so much character. We’d love to return and we highly recommend!
Top Guest favourite
Guesthouse in Clyde
4.97 out of 5 average rating, 154 reviews

Hickory Hill Guesthouse

KatieRating, 5 stars1 month ago
My husband and I spent a long weekend in the area for a wedding and Kellye’s place was the perfect home base. Everything was immaculately clean and comfortable for two! Not to mention the beautiful views from every window! Kellye was so responsive and kind to speak with! I would certainly stay here again. Thank you!
Top Guest favourite
Guesthouse in Shelby
4.99 out of 5 average rating, 275 reviews

Cabin in the Pines

NickRating, 5 stars1 week ago
My only regret is not having more time to hang out on the porch. Lovely place, very cozy and comfortable.

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