Bed and breakfast holiday rentals in Upstate South Carolina

Find and book unique bed and breakfasts on Airbnb

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Popular amenities for Upstate South Carolina bed and breakfasts

Family-Friendly Bed and Breakfasts

Superhost
Hotel room in Clemson
5 out of 5 average rating, 7 reviews

Two private rooms with bathroom

LindsayRating, 5 stars19 months ago
Everything about our stay at Diana’s was perfect! Location, cleanliness, attentiveness and all the extras! She made us feel like family and truly cared about us having a nice and relaxing time while visiting! We will be returning guests, cannot say enough great things about this wonderful lady and her place! Go TIGERS!
Top Guest favourite
Private room in Gatlinburg
4.96 out of 5 average rating, 251 reviews

Practical Elegance

ShachiRating, 5 stars3 weeks ago
Staying with Charles and Diane was more than just a getaway — it felt like being welcomed into a friend’s home. From the start, they made it clear: this is your home while you’re here. Diane is incredibly kind — she made sure we were well-fed, gave us full access to the kitchen, and never let us lift a finger. Charles’s knowledge of the Smoky Mountains was invaluable. He guided us to serene hikes away from crowds and even captured beautiful moments of my partner and me that we’ll always treasure. And the food — unforgettable. Charles’s quiche alone is worth the trip, and yes, the pancakes are orange-infused and absolutely perfect. Their warmth, care, and attention to every little detail made this one of the most meaningful travel experiences we’ve had. We left with full hearts, wonderful memories, and new friends. Can’t wait to return.
Top Guest favourite
Private room in Jefferson
4.96 out of 5 average rating, 68 reviews

One Room - Sleeps 2 Guests Queen Bed on Small Farm

MikeRating, 5 stars10 months ago
I have been so blessed in my Air BNB experiences and John's farm was no exception. He was extremely friendly and his farm was beautiful. Goats , chickens, cows, and the greatest ,pot belly pig ever named "Charlotte" ........a hot tub, an amazing inground pool, piano, guitar, full access to a great kitchen for making meals... very comfortable and nice home......We enjoyed our short time there and will definitely be back.
Private room in Ashville
5 out of 5 average rating, 4 reviews

#8 Rose Room - OaklandCottage B&B

JavanRating, 5 stars1 week ago
Such a pleasure staying here! It was cozy, clean, and beautiful. Breakfast was delicious and they even went above and beyond accommodating our stringent dietary restrictions - something we were NOT expecting. Communication was friendly and helpful, and they did so much for us to help ensure our stay was pleasurable. Truly this place is run with love!
Home in Whittier
4.96 out of 5 average rating, 28 reviews

Great Smoky Mtns- Casino- Outdoor Adventures

KarandaRating, 5 stars2 months ago
This Airbnb was absolutely beautiful!! Melony was very thorough and had great instructions! Definitely recommend to everyone!
Hotel room in Tryon
4.91 out of 5 average rating, 55 reviews

GreenLife Inn at Mimosa Room 202

SueRating, 5 stars48 months ago
Oh my gosh! My friend and I had a girls' weekend in the Tryon area visiting the local wineries and we stayed at the Green Life Inn, and it was a great experience! Mary's special touches were amazing! There were snacks & water in the room, top-quality soaps and shampoo were provided, and the bed linens were AMAZING! To top it all off, Mary provided quite the spread of food for breakfast. Homemade (yummy) muffins, cheesy hashbrowns with sausage, hard-boiled eggs, yogurt, fruit, juice, coffee and much more! We will definitely stay there again! Thank you Mary for your hospitality!
Top Guest favourite
Private room in Irmo
4.99 out of 5 average rating, 92 reviews

Lake Murray Retreat

MaryAnnRating, 5 stars1 month ago
Louise‘s place was wonderful. Very warm and inviting. Handpicked flowers awaited our arrival, along with fresh fruit, snacks, and coffee creamer! Always thankful for coffee creamer!Communication from check-in to check out was great. The house itself is spectacular. The lake view is great! The suite we stayed in was very roomy, and perfectly clean. Would definitely stay again.
Private room in Grover
5 out of 5 average rating, 4 reviews

Former White House Chefs home (Oceanicus Blue rm)

JeremyRating, 5 stars37 months ago
We thoroughly enjoyed our stay at the Inn of the Patriots! The breakfasts were amazing and one of a kind. The tours that Marti gives and the lore he covers are very fun. Also Marti's guidebook was very helpful for touring the area. It's an old home with lots of history. Our room was comfy and clean and we were well cared for.

Bed and breakfast rentals with breakfast

Tiny home in Bryson City
4.82 out of 5 average rating, 17 reviews

"ZEN" luxury tiny home on park-like 11 acre Farm

VadimRating, 5 stars11 months ago
I had an amazing stay at Amy's place "ZEN" on the picturesque farm! The location is absolutely stunning, with beautiful scenery all around. The farm itself is wonderful, providing a peaceful and relaxing atmosphere. The RV trailer that has been transformed into a cozy home is fantastic. It has everything you need for a comfortable stay, and the thoughtful touches made it feel even more special. The space is well-designed, making the most out of every corner. One of the highlights of my stay was the delicious breakfasts. They were delightful and provided a great start to the day. Amy's hospitality truly made a difference, making me feel welcome and cared for throughout my visit. I highly recommend Amy's place "ZEN" for anyone looking for a unique and serene getaway. It’s perfect for those who want to unwind and enjoy nature while still having all the comforts of home.
Private room in Wellford

Skunk Works Farms B&B

HelenRating, 5 stars2 months ago
Heather and her husband are great host and very friendly people. If you love being around animals and love the country life then there place is definitely for you. It made me feel back home. Gave off a good country vibe which I love bye the way .
Private room in Waynesville
4.89 out of 5 average rating, 44 reviews

1.Grandview Lodge in the Great Smoky Mountains

CamiloRating, 5 stars2 weeks ago
Jeffrey was a fantastic host! Super accommodating, the farm to table breakfast was amazing, and it helped us disconnect from everyday life. My wife and I can’t wait to go back!
Private room in Shelby

Green Luxury Room- Morgan & Wells BnB

TylerRating, 5 stars39 months ago
the green room was great and had a lovely old home warmth to it. would definitely stay again!
Private room in Greenville

Hummingbird - Pettigru Place Bed & Breakfast

KyleRating, 5 stars55 months ago
I can’t say enough nice words about Pettigru B&B. Lori is utmost, the most amazing and gracious hostess. She’s taken every detail into consideration when decorating and offers her guest a warm and hospitable place to stay. The breakfast was delicious, the gardens gorgeous. My husband and I cannot wait for our next visit. Xx, Shannon and Kyle Posey
Private room in Abbeville
5 out of 5 average rating, 4 reviews

HayGood Manor Bed & Breakfast - Rooms

Darryl & LeslieRating, 5 stars49 months ago
Haygood Manor is simply amazing! There is deep history and a sense of wonderment in every room. Selena is the ultimate host! Each room is warm and welcoming. Her home is within walking distance to Abbyville's town square where there a plenty of shops and restaurants to visit. We will definitely be back as there is no way you can take in all the Haygood Manor has to offer in one visit!
Private room in Ashville
5 out of 5 average rating, 10 reviews

Cozy Queen in Historic B&B plus fireplace

TaylorRating, 5 stars18 months ago
Wow!! This was such an incredible stay! Diane and Dan are the epitome of what hospitality should be. Our room was amazing, with high quality linens and amenities. There are fresh cookies readily available and the breakfast is heavenly. The location is amazing, tucked away in a beautiful historical neighborhood while still being just a couple of minutes from all that downtown Asheville has to offer. From now on, when we go to Asheville, this is where we will stay! Thank you Dan and Diane for the wonderful experience!!
Private room in Washington
5 out of 5 average rating, 3 reviews

The Historic 1850’s Smith-Stratton Cottage

MaryRating, 5 stars27 months ago
Beautiful cottage with private room and bathroom and dedicated balcony, access to living room, kitchen and dining. Ken is a gracious host. He had chocolate, beer, wine, cheese and crackers and cookies for me when I checked in. The bedroom was extremely comfortable and quiet. Ken made me a fantastic breakfast of my choice and we had a great conversation. I highly recommend this beautiful home and would loved to have stayed longer. I will definitely book the room again when I return!

Bed and breakfast rentals with a patio

Private room in Pendleton

Suite 1 Bridal suite 1 King bed private bathroom.

SusanRating, 5 stars33 months ago
This was a great location to the Clemson Campus. So much better than the local motels. Our room was wonderful and really enjoyed the home cooked breakfast every morning. Will definitely stay here again while visiting Clemson.
Private room in Sylva

Near Casino. Spare bedroom and bath.

nateRating, 5 stars25 months ago
Patricia & her husband were incredibly hospitable, making me feel right at home. The bedroom was cozy and comfortable, ensuring a restful night's sleep. What's more, the affordability of this accommodation was impressive, offering great value for the price. I highly recommend this delightful Airbnb property for a memorable stay that won't break the bank.
Guest favourite
Private room in Etowah
5 out of 5 average rating, 15 reviews

Bed & Breakfast No cleaning fee

KarenRating, 5 stars20 months ago
Elizabeth's place was exactly how it was described on the website. She even greeted us outside, when we arrived, and made us feel right at home! This B&B is close to the Dupont Forest and the Blue Ridge Parkway which was close to our day trip hiking destinations. Downtown Asheville and Brevard are also close by so there's plenty to do. Or if you want to sit and relax on their back porch and read a book that option is also available. We were so comfortable in their home it felt like visiting a long lost friend. Both Jim and Elizabeth had great stories to tell and also gave us a mini concert in their living room. Her weekend breakfasts were outstanding and she's a fantastic cook! I would highly recommend this place to anyone who wants to stay in this area. We will definitely be back.
Apartment in Ashville

Robins Nest—AVL/Biltmore—fp—ct bkfst—hot tub

JessicaRating, 5 stars16 months ago
Our stay was perfect! The space was inviting, incredibly clean and well maintained. It is a perfect cozy spot for a winter getaway but I would also love to visit any other time of year. Robin’s Nest is at the top of our list when we return to Asheville.
Private room in Belton
4.62 out of 5 average rating, 13 reviews

King Suite in Historic Bed and Breakfast

BrandonRating, 5 stars19 months ago
it was great for peaceful night in. The property was beautiful
Guest favourite
Private room in Greenville
4.97 out of 5 average rating, 209 reviews

B & B/Downtown/Furman/BJU/1

LaShaunRating, 5 stars3 weeks ago
It was a lovely & peaceful stay as always!
Apartment in Gatlinburg
4.87 out of 5 average rating, 85 reviews

Gatlinburg Family Suite! | Trolly Stop! | Wi-Fi!

EricaRating, 5 stars1 month ago
This was a great place to stay. It was next to a trolly stop which is convenient. It’s about a 20-30 min walk from downtown. There were restaurants across the street. Alamo Steakhouse is delicious! The little deck was nice and the river outside was so peaceful. Inside was a cute cabin set up with everything you needed.
Private room in Pelzer

Charming Pelzer Historic Inn

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