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Guesthouse holiday rentals in Santa Cruz de la Sierra

Find and book unique guesthouse rentals on Airbnb

Top-rated Guesthouses in Santa Cruz de la Sierra

Guests agree: These guesthouses are highly rated for location, cleanliness and more.

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Private room in Santa Cruz de la Sierra

Mirador del Cielo - Boutique Apart Hotel 2

Sky Apartment es ideal para viajeros que buscan un lugar cómodo, elegante y con todas las comodidades para disfrutar al máximo su estadía. A solo 15 minutos del Aeropuerto Internacional de Viru Viru y con acceso fácil a las principales zonas de la ciudad. Relájate en la piscina ubicada en el último piso, disfruta del jacuzzi, sauna seco y de vapor, o prepara una deliciosa parrillada con amigos y familiares ¡Te esperamos para que vivas una experiencia única en Santa Cruz de la Sierra!

A cozy living space is presented with a comfortable sectional sofa featuring decorative cushions. A coffee table sits in front, with a sleek television mounted on a modern cabinet. Natural light enters through large windows, and a potted plant adds a touch of greenery.
Guesthouse in Santa Cruz de la Sierra

Horizontal duplex in backyard of house with pool

Enjoy a semi-detached duplex (complete) in the backyard of my house. With its own entrance to the duplex, it shares an entrance to the property. Located in a safe and quiet area easily accessible, close to shops, markets, supermarkets, pharmacy, public transportation (blocks from the main avenues), by car 10 min. from the center, 5 min. from the Fexpo, 30 to 40 min. from the airport, 1 block walk from the society of engineers SIB, clinic Montalvo and Urbari.

A multi-story building is showcased, featuring a distinctive red facade with decorative archways. Balconies extend from the upper floors, providing outdoor space. The ground level houses various storefronts, while utility poles and street signs are visible, indicating a lively urban environment.
Guesthouse in Santa Cruz de la Sierra
4.42 out of 5 average rating, 12 reviews

Cozy family home in Santa Cruz de la Sierra

Family house of 320 square meters, on the second floor, with all the utensils and home clothes, wonderful views from its 30 meters of terrace. Ideal for families who want to have a quiet stay of any duration in the City of Santa Cruz de la Sierra. Very well connected with several bus lines that take you to the entire city and surroundings and very close to the Santuario de Cotoca. Nearby has all kinds of services, breakfasts, meals, markets, shops, etc.

Guest favourite
Private room in Centro
5 out of 5 average rating, 6 reviews

Room in the center, two minutes from everything!

Experience staying in the heart of Santa Cruz, just 3 blocks from the main square. Our bright and cosy room awaits you in a safe and lively area: museums, cafes, bars, shops and historical spots are just a few steps away. Ideal for those looking for comfort, style and an unbeatable location. With WiFi, details designed for your relaxation and service that will make you feel at home.

A spacious common area features comfortable seating arrangements with a mix of sofas and chairs. A central table is set with placemats, while a ceiling fan and air conditioning unit contribute to a comfortable environment. Light filters through large windows, enhancing the welcoming feel.
Guesthouse in Santa Cruz de la Sierra

Spacious house with a patio and parking

Guest house, with large patio and grill (churrasquera), in a very quiet area. A/C in all environments, thermotank (hot water), Wi-Fi, spacious living room. Suite with private bathroom. Common bathroom, sofa-bed and spacious sofa on the ground floor. (Can sleep comfortably up to 4 people) Address: km 8, Barrio 14 de Agosto, Calle 3 Between double via guard and radial 17 and a half

Guesthouse in Centro

Complete centric apartment with garden and pool

Complete centric apartment with an enormous garden and pool. Private apartment with fully staffed kitchen, private bathroom and a bedroom with a queensized bed. You'll also have access to the big garden and the pool to relax and refresh yourself. By choosing our accommodation, you’re also supporting Ñañope, a local NGO dedicated to empowering household workers in Santa Cruz.

A well-equipped kitchen features wooden cabinets and a countertop with colorful tiles. A small refrigerator and an oven are included, alongside a wooden dining table with four chairs, creating a functional space for meal preparation and dining.
Guesthouse in Santa Cruz de la Sierra
5 out of 5 average rating, 56 reviews

Lodge surrounded by nature in the city

We renewed our lodge for more comfort for our guests: Imagine a little house surrounded by trees and plants, easy to go and not far away from city center. We´re living on half a hectar and your new place for working o relaxing is inside this paradise. You´re completely independent from us, with all you need for taking a rest or work, including the swimming pool.

Private room in Centro
4.5 out of 5 average rating, 4 reviews

Double or Full Room in Downtown

New and elegant building located just 2 blocks from the main square, surrounded by shopping malls, restaurants, cafes, jewelry, jewelry, perfumerias, it is located a couple of blocks from the house of culture, the cathedral, museums, 1 block, banks, 7 streets market and various shops and locals.

Guest favourite
A cozy bedroom features a spacious bed dressed in neutral linens, accompanied by decorative cushions. Two wooden chairs are positioned beside a round table near a window with light curtains. A wooden nightstand stands beside the bed, contributing to the room's welcoming atmosphere.
Guesthouse in Centro
4.88 out of 5 average rating, 112 reviews

Private Apartment In Downtown

Welcome to our cozy guest house in one of the most beautiful and safe areas of the center! Just 6 blocks from Plaza 24 de Septiembre, our historic neighborhood offers you a unique experience.

Guesthouse in Santa Cruz de la Sierra

Casa Portal Holístico # 1

Disfruta de este espacio místico de tranquilidad y armonía dónde tus noches serán restauradas y revitalizantes con la energía del Portal Holístico

Private room in Santa Cruz de la Sierra
New place to stay

Apartment-style room

Desconecta de tus preocupaciones en este espacio tan amplio y sereno.

Private room in Santa Cruz de la Sierra
New place to stay

department to share TamisaIII

Disfruta de la sencillez de este alojamiento tranquilo y céntrico.

Popular amenities for Santa Cruz de la Sierra guesthouses

Quick stats about guesthouse rentals in Santa Cruz de la Sierra

  • Total holiday rentals

    Explore 50 holiday rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra holiday rentals start at $15 AUD per night before taxes and fees

  • Verified guest reviews

    Over 350 verified reviews to help you choose

  • Pet-friendly accommodation

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    50 of Santa Cruz de la Sierra holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wi-Fi and Pool across Santa Cruz de la Sierra rentals

Destinations to explore