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Holiday houses in Santa Cruz de la Sierra

Find and book unique accommodation on Airbnb

Quick stats about holiday rentals in Santa Cruz de la Sierra

  • Total holiday rentals

    Explore 4,380 holiday rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra holiday rentals start at $14 AUD per night before taxes and fees

  • Verified guest reviews

    Over 59,960 verified reviews to help you choose

  • Family-friendly holiday rentals

    1,170 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 1,180 rentals that welcome pets

  • Holiday rentals with a pool

    2,980 properties feature pools

  • Rentals with dedicated workspaces

    2,510 properties have a dedicated workspace

  • Wi-Fi availability

    4,040 of Santa Cruz de la Sierra holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Santa Cruz de la Sierra rentals

  • 4.7 Average rating

    Santa Cruz de la Sierra stays receive an average rating of 4.7 out of 5 from guests

Top-rated holiday rentals in Santa Cruz de la Sierra

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
A modern living area is furnished with a gray sofa and a brown accent chair. A wooden coffee table sits on a textured rug in front of the sofa. Natural light floods in through large windows, illuminating the open layout that connects to an equipped kitchen.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 54 reviews

Luxury and comfort in every detail

This apartment combines luxury, style, and comfort in every detail. Designed as a boutique hotel, it offers a unique experience with impeccable finishes, an equipped kitchen, a cozy living room, spacious bedrooms, and a beautiful balcony to relax. Located in the heart of Equipetrol and a short walk from restaurants, shops and attractions. Perfect for business trips or relaxation, this modern and elegant space is ideal for relaxing and enjoying an unforgettable stay. You'll love it! Parking is included!

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 5 reviews

Beautiful, spacious and unique apartment in the best area.

Create unforgettable memories in this unique and family home. Exceptional 122 m2 apartment in the heart of Equipetrol. Very quiet place to rest or work, but at the same time close to fun. You'll have an amazing stay! Spacious, modern, furnished and decorated apartment, A/C, Wi-Fi, 65" and 55" 4K Smart TVs, kitchen, 2 bedrooms, 3 bathrooms, private laundry and drying area, ample free parking at the entrance 24 hours a day. Beautiful swimming pool and sauna. Large balcony with a nice city view.

Superhost
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 3 reviews

Skyline Luxury • Rooftop, Piscina, Billar & Lounge

Designed for discerning guests looking for a superior 5-star hotel experience. Located in Equipetrol, the most exclusive and secure area of Santa Cruz, this elegant apartment in the penultimate apartment offers double balcony with unique views! Premium amenities like sky pool, lounge, billiards, churrasqueras, full gym and more! Surrounded by the best restaurants, bars, coffees, theaters, shops and business centers. Ideal for executive trips, luxury getaways or unforgettable stays.

Superhost
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 4 reviews

Exclusive 2-bedroom apartment, 21st floor, Mare – Equipetrol

Hospédate in this elegant 2 bedroom apartment on Mare's 21st floor, premium condominium in Equipetrol. It has a private balcony and a view towards one of the most exclusive areas of Santa Cruz, near Manzana 40 and Green Tower. Great for business trips or rest with parking. The apartment offers the perfect balance between comfort and sophistication, with top-notch amenities to make the most of your stay: swimming pool, jacuzzi, gym, barbecue grills, co-working spaces, and more.

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 6 reviews

Mare Residence · Piso 15 · Monoambiente

Enjoy a modern stay in Mare, one of the most exclusive buildings in Santa Cruz. This elegant studio on the 15th floor offers city views, a private balcony, a double bed and a sofa bed for up to 3 guests. It has a Smart TV, Netflix, Wi-Fi, air conditioning, a fully equipped kitchen, an oven and a microwave. Enjoy resort-style social areas with a 30-metre pool, co-working space, bar, pool table, green areas and an excellent location close to restaurants and shopping centres.

Guest favourite
Apartment in Santa Cruz de la Sierra
4.84 out of 5 average rating, 32 reviews

Penthouse on Avenida Beni

This is the one! Located minutes from restaurants, shopping, and downtown, it doesn't get much more convenient than this! With a fully equipped kitchen, comfortable bedrooms and a cozy environment Step into this apartment and let the cozy surroundings instantly appeal to you! Here you will find everything you need to make this your home away from home. From the thoughtful decor and thoughtful furnishings, this place has been designed to make everyday life beautiful.

Guest favourite
A contemporary entryway featuring sleek, metallic walls and smooth marble flooring. A minimalist reception desk with soft ambient lighting displays the name 'NUU.' A large potted plant adds a touch of greenery, while well-placed lighting creates a bright atmosphere.
Apartment in Santa Cruz de la Sierra
4.93 out of 5 average rating, 73 reviews

apartment with an excellent view

Apartment located in the Equipetrol area. Located on the 13th floor, you'll enjoy stunning views in a comfortable and elegant atmosphere. This apartment has two bedrooms and two bathrooms, ideal for families or groups. It's fully equipped to make you feel at home. Among the building's amenities, you will find a cinema, a swimming pool, a barbecue area, an equipped gym, a playground, and parking for visitors. Easy access to restaurants, shops, and attractions.

Guest favourite
Apartment in Santa Cruz de la Sierra
4.83 out of 5 average rating, 6 reviews

POX: Luxury at Atrium Equipetrol | 9th floor

Stay in an exclusive one-bedroom apartment on the 9th floor of the Atrium Building, where elegance, contemporary design and fine décor create a first-class experience. Located in the heart of Equipetrol, on Av. Enrique Finot, you'll enjoy a quiet and safe area, just a short walk from restaurants, cafes and business centres. The space is fully equipped to provide you with a comfortable, sophisticated and unforgettable stay. Rest - Enjoy - Repeat

Superhost
Apartment in Santa Cruz de la Sierra
4.6 out of 5 average rating, 5 reviews

Balcony on 17th floor / Desk / Swimming pool / Gym

Meters from the 2nd ring, Equipetrol area, many restaurants, shops, supermarkets, gyms among others. With a balcony and a view of the 17th floor, pool, work area, gym and others in the social areas. Apartment with: -WiFi 100Mbps - Kitchen - Washing machine -Smart TV - Equipped bathroom - Bed - Pull-out sofa - 100 Mbps Wi-Fi In the building you will have: -swimming-pool - Gym - Sauna - Work area - Games area Live the experience and book ya!

Top Guest favourite
A comfortable sleeping area features a spacious bed adorned with soft pillows and a decorative throw. Warm bedside lamps illuminate the space, while large windows offer views of the surrounding cityscape and allow natural light to brighten the room.
Apartment in Santa Cruz de la Sierra
4.98 out of 5 average rating, 135 reviews

13° SmartLife - Luxury Equipetrol

Welcome to your sanctuary of sophistication and elegance at the top. This exceptionally cozy and stylish studio on the 13th floor invites you to experience luxury and comfort at their finest. Ready to experience the perfect combination of sophistication, comfort, and technology? Don't miss out on this unique opportunity. Book your stay at "13° SmartLife" and be seduced by the charm of this incomparable space! Your urban retreat awaits.

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 29 reviews

Equipetrol, Fantastic 2 Bedroom Apartment

Enjoy luxury and comfort with your family in the best area of Santa Cruz, Equipetrol! Welcome to the exclusive ARA Tower, where modern design merges with functionality in this stylish 2 bedroom apartment fully equipped, for your comfort. We also offer: infinity pool, lounge, rooftop barbecue and 24/7 security. You'll be steps away from the best restaurants, cafes, and nightlife. Book now and have an unforgettable experience!

Guest favourite
Apartment in Santa Cruz de la Sierra
5.0 out of 5 average rating, 9 reviews

Equipetrol Norte, 2 Bedrooms+Pool+Balcony

Experience Equipetrol Norte, the city's most exclusive and vibrant area. Enjoy a spacious accommodation full of details, with a balcony. Ideal for long stays, group trips or family trips. Relax in the panoramic pool, enjoy the barbecue with spectacular views, or take advantage of the coworking space, ideal for combining rest and productivity. A stay designed to enjoy every moment in style and comfort.

Popular amenities for Santa Cruz de la Sierra holiday rentals

Frequently Asked Questions

  • What are the best places to stay in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has stays in lively neighborhoods like Equipetrol, known for dining and nightlife, and around the city center near plazas and shops. Guests often appreciate areas with leafy streets, local cafes, and easy access to cultural sites.

  • What are the best things to do in Santa Cruz de la Sierra with kids?

    Families can explore city parks, interactive museums, and local zoos featuring native wildlife. Playgrounds and green spaces in residential neighborhoods add opportunities for outdoor fun.

  • What are some of the best things to do in Santa Cruz de la Sierra?

    Discover central plazas, explore Museo de Historia Natural Noel Kempff Mercado, and wander bustling traditional markets. The city also has botanical gardens, art spaces, and vibrant street life.

  • How is the weather in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra generally has warm, humid conditions year-round, with wetter spells in certain months and a tropical atmosphere. Lightweight clothing and sun protection are often suggested, especially for daytime outings.

  • What are the best places to visit in Santa Cruz de la Sierra?

    Explore Plaza 24 de Septiembre, admire local art at Museo de Arte Contemporáneo, and stroll the city’s botanical gardens. Markets and lively pedestrian zones add extra color to the experience.

  • What are some hiking trails in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has nature reserves and eco-parks where visitors can follow shaded trails amidst tropical plants and birds. Urban green spaces and parks also provide pathways for relaxed walks.

  • What are some family activities we can do in Santa Cruz de la Sierra?

    Families frequently explore city zoos, botanical gardens, interactive museums, and open-air playgrounds. Participating in local craft workshops or tasting fresh fruit at traditional markets brings a sense of discovery.

  • What are some of the best day trip ideas from Santa Cruz de la Sierra?

    Day trips often include exploring nature reserves, visiting Jesuit mission towns, or discovering small communities with locally rooted traditions. Eco-parks around the city provide hiking, birdwatching, and opportunities to connect with regional culture.

  • Are there any pet friendly accommodations available in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has pet-friendly vacation rentals in neighborhoods like Equipetrol, Urbarí, and around the city center. Many stays include access to green spaces and parks for walks with your pet.

  • What are some local tips for visiting Santa Cruz de la Sierra?

    Locals appreciate lightweight clothes for the heat, insect repellent, and comfortable shoes for exploring urban sights. Trying locally grown fruits at traditional markets is frequently suggested, and learning some Spanish phrases adds ease to your experience.

  • What is Santa Cruz de la Sierra known for?

    Santa Cruz de la Sierra is known for its lively main plaza, tropical botanical gardens, and dynamic blend of Indigenous and European traditions. The city’s vibrant markets, local cuisine, and arts scene are frequently highlighted.

  • What are the best hidden gems to explore in Santa Cruz de la Sierra?

    Around Santa Cruz de la Sierra, visitors often discover small artisan shops, tranquil eco-parks, and street murals tucked in residential neighborhoods. Community-run cafés and weekend craft markets add unique flavor.

  • What are the best foods to try in Santa Cruz de la Sierra?

    Local favorites include salteñas, sonso de yuca, and traditional dishes made from corn, plantain, and tropical fruits. Refreshing drinks such as mocochinchi and locally roasted coffee are often recommended.

  • What should I bring for a trip to Santa Cruz de la Sierra?

    Pack lightweight clothing, sun protection, insect repellent, and comfortable shoes for walking. Bringing a reusable water bottle and rain jacket can add convenience, especially if you plan outdoor excursions.

  • What is the nightlife in Santa Cruz de la Sierra like?

    Santa Cruz de la Sierra has lively nightlife, with bars and clubs frequently suggested around the Equipetrol neighborhood. In the city center, you can explore relaxed venues featuring live music, local cocktails, and outdoor patios.

  • What are the most popular events or festivals in Santa Cruz de la Sierra?

    Santa Cruz de la Sierra has celebrated cultural festivals, Carnaval, and regional fairs throughout the year. Music, dance, and food events are frequently suggested, especially around holidays and community celebrations.

  • Are there family friendly vacation rentals in Santa Cruz de la Sierra?

    Family-friendly vacation rentals can be found in Equipetrol, Urbarí, and the city center, many with spacious layouts and access to parks or play areas. Hosts often provide amenities for children to make visits comfortable.

  • When is the best time to visit Santa Cruz de la Sierra?

    Visitors often prefer the drier months for outdoor activities and exploring city sights, while some enjoy the lush greenery during wet seasons. Popular festivals and pleasant evenings draw many travelers throughout the year.