
Villa holiday rentals in Los Santos Province
Find and book unique villas on Airbnb
Top-rated villa rentals in Los Santos Province
Guests agree: These villas are highly rated for location, cleanliness and more.

Horizonte Luxe Villa 3BR, Infinity & Indoor Pool
Sky above, waves ahead, luxury all around — welcome to Villa Horizonte! Nestled in the exclusive beachfront community of Pedasí on the beautiful Azuero Peninsula, Villa Horizonte offers breathtaking ocean views and the perfect blend of privacy and comfort. This sun-drenched, elegant villa features 3 spacious bedrooms and 3 luxurious bathrooms, accommodating up to 4 adults and 3 children. Enjoy your own private infinity pool, direct beach access, and panoramic horizons that promise unforgettable
LocationFamilyHospitality

El Nido, Jungle Villa with Pool at Venao
Escape to El Nido, a stunning 3-bedroom, 3-bathroom jungle villa offering the perfect blend of tranquility and modern comfort. Nestled in Playa Venao, Panama, this boho-chic home features vibrant interiors, breathtaking ocean views, and a private pool. Ideal for families, groups, or remote workers, El Nido is just 2 minutes from the beach and Venao’s lively center, where you’ll find top dining, activities, and local charm. With high-speed Wi-Fi, a fully equipped kitchen, and spacious living area
LocationFamilyIndoor spaces

Playa Laska – Oceanfront Escape with Infinity Pool
Welcome to Playa Laska, a luxury beachfront villa where tropical elegance meets modern comfort. With three beautifully designed bedrooms, a private infinity pool, and open-air decks surrounded by lush greenery, every corner invites you to unwind, connect, and savor the ocean breeze. Start your mornings with the sound of waves, relax by the pool or stroll along the shore, and let evenings unfold with dining under the stars. Every corner is thoughtfully crafted for a seamless and relaxing stay.
FamilyLocationIndoor spaces

Villa Verde - Luxury & Cozy Villa 1BR #26 BlueVenao
Relax & Calm in a cozy villa with an amazing view of the mountains, located in Playa Venao Beach The villa is fully equipped with 1 Queen size bed and a Sofa bed, High Speed Wi-Fi, Netflix, kitchen cooking tools and appliances like stove, oven, dishwasher, microwave, coffee maker, toaster and blender. Also, you will find a complete laundry with washer and dryer, towels for use inside the Villa, as well as for the pool & beach. Bedrooms come with complete bedding clothes/linens and pillows
FamilyLocationDecor

Luxury Villa at Blue Venao | Steps from the beach
Welcome to your dream escape at Blue Venao Resort! Duplex 48B is a stunning, newly built designer duplex just 1 minute walk from the beach! Sleeping 7 guests across 3 beautifully appointed bedrooms, each with its own en-suite bathroom and AC. Soaring cathedral ceilings, a fully equipped gourmet kitchen, and a private terrace with spiral staircase. Located in the closed gated community of "Blue Venao", you'll enjoy an infinity pool, restaurant, surf school and kids playground — all on site.

Casa Almendra
A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.
FamilyLocationComfort

Casa Colibrí, Pedasi
Immerse yourself in this beautiful custom built villa, within walking distances to one of Pedasi’s best beaches. The villa has many things to offer you from a fully equipped kitchen, private pool, bbq area, along with WIFi. The villa offers a tropical retreat with an ocean view, a covered patio with chairs and table to sit while you enjoy a glass of wine and listen to the sound of the waves crashing. In the evenings sit and relax by the fire pit and listen to the water feature and ocean.
FamilyValueBathroom

Esplendorosa | Ocean View Villa with Staff & Chef
7 Bedrooms | Up to 16 Guests Luxury Villa with Pool & Ocean View – Staff & Chef Included Welcome to Villa Esplendorosa, a high-end villa located just a short walk from Destiladeros Beach, in Pedasí, Panama. The villa offers an elegant oceanfront setting with on-site staff, ideal for a relaxing and worry-free stay. You will enjoy: • Private swimming pool • Stunning ocean views • Daily staff included (chef & housekeeping until 2:00 pm) • Home cinema area • Power generator and Internet
ValueFamilyOutdoor spaces

Playa Venao Blue 12 | Luxury Beach Escape Villa
A 3 bedroom villa centrally located at Blue, A gated community in Playa Venao with everything at your doorstep. Just a few minutes walk to the beach, local shops, restaurant and grocery store. Access to an oceanfront beach club that hosts an infinity pool, restaurant and casual sitting area. Enjoy the best of Playa Venao a great surf spot for beginners and experienced surfers. Local tours, yoga and fitness, restaurants and music. Playa Venao offers something for everyone.
HospitalityComfortCleanliness

Villa Nalu - Venao Beach
Villa Nalu by the Sea Wake up to ocean views and the sound of the waves at Villa Nalu, a stylish coastal home just steps from the sand in Playa Venao. With four bedrooms and four bathrooms, Villa Nalu comfortably accommodates up to seven guests. Spend your days surfing, swimming, or relaxing by the private pool. Gather in the modern, fully equipped kitchen, stay connected with Starlink WiFi, enjoy the natural beauty of Playa Venao. Make yourself at home at Villa Nalu.
LocationFamilyHospitality

Villa "La Décima" comfortable property to enjoy!
We are located in the spectacular area near to Belisario Porras Park & Church of Santa Librada. Las Tablas City is well known for Carnival celebration, beautiful queens, great float parade, fireworks, music. The Town is a 10 minute walk distance & boasts a wide variety of restaurants, bars and shops. Local activities include: handicrafts, local museum, traditional dance, folklore, Panamenian local food, great rivers and beautiful beaches.
FamilyHospitalityAccuracy

Casa Vida, Breathtaking Ocean View Villa
Casa Vida is a spacious six-bedroom villa perfectly located in the heart of Playa Venao, just minutes from the beach, surf, and restaurants. With breathtaking ocean views, a large private pool, expansive living areas, and modern comforts, it’s ideal for families, groups, or retreats. Concierge service is included to help arrange activities, transport, and everything you need for a seamless stay.
FamilyLocationDecor
Popular amenities for Los Santos Province villa rentals
Private villa rentals

Pacific Escape
LocationFamilyAmenities

Modern Villa in Blue Venao + Beach Club Access
LocationBeachKitchen

Stylish & Cozy 3BR Villa 29 at Playa Venao
LocationFamilyCheckout

Lovely Bohemian Style 3BR Villa 35 at Playa Venao
LocationFamilyBeach

Family Surf Villa with Resort Amenities at Venao
QuietLong stayKitchen

Bohemian Villa 3BR at Playa Venao
LocationFamilyPool

3min walk to the Beach 2BR Villa 20 at Playa Venao
ValueLocationCleanliness
Luxury villa rentals

Villa Sirena – Blue Venao
FamilyLocationAccuracy

Villa La Piragua: 3BR Surfside Retreat: 5-7G
LocationValueHospitality

Villa del Sol Panama-Private Paradise
FamilyLocationTV

Casa Rosita 49' - VENAO BEACH

Luxury Apartment at Blue Venao with Private Pool

Villa Ceviche, Surf Villa at the Heart of Venao
FamilyValueQuiet

Esplendorosa, Ocean View Suites with Staff & Chef
LocationHospitalityCleanliness

Family Perfect Getaway 3BR Villa 6 at Playa Venao
LocationFamilyGetting around
Villa rentals with a pool

Villa Tortugas, Blue Playa Venao / Beachfront Club
FamilyLocationAmenities

VENAO - BLUE27 COZY VILLA
LocationViewPets

Luxurious Villa Bella Vista
LocationFamilyIndoor spaces

Villa Priscilla at Blue Venao | Sleeps 6 | 3BR/3BA

Villa Ocean Pearl 2 Bedrooms 2 Baths at Blue Venao
LocationFamilyCleanliness

Casa Tucán by LAR architects • Sea view Studio 01

3-BR Villa with Infinity Pool
FamilyKitchenPool

Steps to the Beach 3BR Villa 36 at Playa Venao
FamilyLocationSleep quality
Destinations to explore
- Bed and breakfasts Los Santos Province
- Pet-friendly rentals Los Santos Province
- Rentals with pools Los Santos Province
- Rentals with beach access Los Santos Province
- Hotel rooms Los Santos Province
- Condo rentals Los Santos Province
- Boutique hotels Los Santos Province
- Beachfront rentals Los Santos Province
- Rentals with a hot tub Los Santos Province
- Waterfront rentals Los Santos Province
- Rentals with an accessible height bed Los Santos Province
- Family-friendly rentals Los Santos Province
- Apartment rentals Los Santos Province
- House rentals Los Santos Province
- Guesthouse rentals Los Santos Province
- Villa rentals Panama





