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Villa holiday rentals in Los Santos Province

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Top-rated villa rentals in Los Santos Province

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An aerial view of a modern, three-bedroom villa nestled among dense green foliage. The structure features a light-colored exterior with a metal roof. A pool area is visible at the back, framed by lush trees, creating a sense of privacy and connection to nature.
Villa in Las Escobas del Venado
4.75 out of 5 average rating, 8 reviews

El Nido, Jungle Villa with Pool at Venao

Escape to El Nido, a stunning 3-bedroom, 3-bathroom jungle villa offering the perfect blend of tranquility and modern comfort. Nestled in Playa Venao, Panama, this boho-chic home features vibrant interiors, breathtaking ocean views, and a private pool. Ideal for families, groups, or remote workers, El Nido is just 2 minutes from the beach and Venao’s lively center, where you’ll find top dining, activities, and local charm. With high-speed Wi-Fi, a fully equipped kitchen, and spacious living area

Guest favourite
A serene sunset casts soft hues of orange and pink across a calm ocean surface. Gentle waves reflect the sky's colors, while distant hills create a subtle silhouette along the horizon.
Villa in Las Escobas del Venado
5 out of 5 average rating, 19 reviews

Villa Tortugas, Blue Venao/Beachfront Club

Enjoy a spectacular Villa, just a short 3-minute walk to the beach in the most exclusive gated community, with security guards, surveillance & parking. There are 2 bedrooms, each with a private bathroom and an extra bathroom for guests, full kitchen, living room, and a beautiful terrace to rest with friends and family. The house has a 65" Samsung Smart TV/Apple TV, 130MB Wi-Fi internet in each room, & air conditioning. Our facilities at the oceanfront clubhouse & restaurant are exquisite.

Guest favourite
Villa in Playa Venao
5 out of 5 average rating, 10 reviews

Playa Laska – Oceanfront Escape with Infinity Pool

Welcome to Playa Laska, a luxury beachfront villa where tropical elegance meets modern comfort. With three beautifully designed bedrooms, a private infinity pool, and open-air decks surrounded by lush greenery, every corner invites you to unwind, connect, and savor the ocean breeze. Start your mornings with the sound of waves, relax by the pool or stroll along the shore, and let evenings unfold with dining under the stars. Every corner is thoughtfully crafted for a seamless and relaxing stay.

Guest favourite
An inviting infinity pool extends toward the beach, featuring sleek lounge chairs positioned at the water's edge. Lush greenery surrounds the pool area, while a tall palm tree adds a tropical touch against the backdrop of the ocean and clear blue sky.
Villa in Playa Venao
4.91 out of 5 average rating, 56 reviews

Villa Verde - Luxury & Cozy Villa 1BR #26 BlueVenao

Relax & Calm in a cozy villa with an amazing view of the mountains, located in Playa Venao Beach The villa is fully equipped with 1 Queen size bed and a Sofa bed, High Speed Wi-Fi, Netflix, kitchen cooking tools and appliances like stove, oven, dishwasher, microwave, coffee maker, toaster and blender. Also, you will find a complete laundry with washer and dryer, towels for use inside the Villa, as well as for the pool & beach. Bedrooms come with complete bedding clothes/linens and pillows

A shaded patio area features comfortable seating arrangements with dark wicker chairs and a matching table. An oceanfront saltwater pool is visible with loungers arranged beside it. Lush palm trees sway gently in the background against a clear blue sky.
Villa in Cambutal
4.67 out of 5 average rating, 21 reviews

Casa Almendra

A 3-bedroom luxury villa located on the pristine beaches of Cambutal, Panama. This beachfront paradise offers everything you need for a truly unforgettable stay... A spacious and elegantly designed living area, an open-concept kitchen, fully equipped with top-of-the-line appliances and breathtaking ocean views, and an oceanfront saltwater pool surrounded by comfortable loungers. Entirely off-grid with a state-of-the-art solar power system, your stay is not only luxurious but eco-friendly.

Villa in Pedasi
4.67 out of 5 average rating, 94 reviews

Super Private Beachfront 3BR Villa & Infinity Pool

Sky above, sand below, peace within ~ Welcome to la Dolce Vita! Located in Andromeda, an oceanfront gated community on the Azuero Peninsula. Andromeda villas offer amazing and unparalleled ocean views where you can be with the sights and sounds of nature at its most beautiful. Our sun-filled and stunning Villa is 3 bed / 3 bath for up to 4 adults and 3 kids Features a spectacular view, private pool and direct beach access. Fully equipped so you can feel at home and enjoy your getaway!

Guest favourite
A private pool is set within a spacious outdoor area, surrounded by tropical plants and palm trees. The villa's exterior features a covered patio and a beautifully patterned tiled deck, providing an inviting space for relaxation under a clear blue sky.
Villa in PA
4.88 out of 5 average rating, 16 reviews

Casa Colibrí, Pedasi

Immerse yourself in this beautiful custom built villa, within walking distances to one of Pedasi’s best beaches. The villa has many things to offer you from a fully equipped kitchen, private pool, bbq area, along with WIFi. The villa offers a tropical retreat with an ocean view, a covered patio with chairs and table to sit while you enjoy a glass of wine and listen to the sound of the waves crashing. In the evenings sit and relax by the fire pit and listen to the water feature and ocean.

A bright living area is equipped with a spacious light-colored sofa and a textured throw blanket. Large glass doors allow natural light to fill the room, while rattan light fixtures and a casual dining space with barstools enhance the relaxed ambiance.
Villa in Las Escobas del Venado
4.8 out of 5 average rating, 5 reviews

Villa Del Mar - Blue Venao 3 Bedroom

Villa Del Mar is a modern beach villa in the most luxarious resort in Playa Venao - 'Blue'. Only 2 minute walking distance from the beach and an exclusive beach club where you will have access to a stunning beachfront infinity pool, delicious restarunt, and a spacious relaxation area. The Blue community is a relaxed, central and secure gated community where you will always be just a few minutes walking distance from the best restaurant, surfing spots, parties and of course - the beach!

Villa in Los Santos Province
4.89 out of 5 average rating, 27 reviews

Esplendorosa | Ocean View Villa with Staff & Chef

7 Bedrooms | Up to 16 Guests Luxury Villa with Pool & Ocean View – Staff & Chef Included Welcome to Villa Esplendorosa, a high-end villa located just a short walk from Destiladeros Beach, in Pedasí, Panama. The villa offers an elegant oceanfront setting with on-site staff, ideal for a relaxing and worry-free stay. You will enjoy: • Private swimming pool • Stunning ocean views • Daily staff included (chef & housekeeping until 2:00 pm) • Home cinema area • Power generator and Internet

Guest favourite
The inviting living space features a plush white sofa adorned with textured cushions. A modern kitchen with sleek stainless steel appliances and bar seating is visible in the background. Pendant lights provide soft illumination, creating a cozy atmosphere.
Villa in Playa Venao
4.93 out of 5 average rating, 45 reviews

Villa La Piragua: 3BR Surfside Retreat: 5-7G

Welcome to Villa La Piragua, an enchanting sanctuary in Blue Playa Venao. Let yourself go in this tropical paradise with pristine beaches. This beautiful villa offers 3 comfortable bedrooms and 3 well appointed baths. Two bedrooms have dreamy queen beds, while the third features a bunk bed with a pullout and an additional twin bed. All bedrooms have smart TV's and WiFi. Enjoy a serene spacious atmosphere in the living area, kitchen, and terrace, ensuring a memorable family getaway.

Guest favourite
A spacious living area features a modern gray sofa paired with a wooden coffee table, accented by a woven rug. Bright light floods in through large sliding glass doors, which offer a view of the lush garden outside. Bar stools surround a kitchen island in the background.
Villa in Playa Venao
5 out of 5 average rating, 8 reviews

Playa Venao Blue 12 | Luxury Beach Escape Villa

A 3 bedroom villa centrally located at Blue, A gated community in Playa Venao with everything at your doorstep. Just a few minutes walk to the beach, local shops, restaurant and grocery store. Access to an oceanfront beach club that hosts an infinity pool, restaurant and casual sitting area. Enjoy the best of Playa Venao a great surf spot for beginners and experienced surfers. Local tours, yoga and fitness, restaurants and music. Playa Venao offers something for everyone.

Superhost
Villa in Las Tablas

Villa "La Décima" comfortable property to enjoy!

We are located in the spectacular area near to Belisario Porras Park & Church of Santa Librada. Las Tablas City is well known for Carnival celebration, beautiful queens, great float parade, fireworks, music. The Town is a 10 minute walk distance & boasts a wide variety of restaurants, bars and shops. Local activities include: handicrafts, local museum, traditional dance, folklore, Panamenian local food, great rivers and beautiful beaches.

Popular amenities for Los Santos Province villa rentals