House holiday rentals in Los Santos Province

Find and book unique houses on Airbnb

Top-rated house rentals in Los Santos Province

Guests agree: These houses are highly rated for location, cleanliness and more.

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Guest favourite

A beachfront house features a thatched roof and is elevated on stilts, surrounded by lush greenery and palm trees. The structure showcases a spacious porch with wooden railings, offering a shaded area for relaxation and enjoying the natural landscape.

Home in Cambutal

4.97 out of 5 average rating, 37 reviews

Beachfront Gem w/ Ocean Views & Prime Surf Access

Welcome to your slice of beachfront paradise! Our home sits right on Cambutal's beautiful shoreline. Gorgeous ocean views greet you from every window, while the gentle rhythm of waves creates the perfect soundtrack for your stay. We've equipped the house with Starlink WiFi and a large dining table that doubles as an ideal workspace, making this a perfect retreat for both vacationers and remote workers. The house feels like a real home – comfortable, clean, and ready for your beach memories.

LocationFamilyWi-Fi

Top Guest favourite

An open-concept living area showcases a modern design with a neutral color palette. A plush gray sofa faces a minimalist coffee table, complemented by a decorative plant. Large windows invite natural light, while soft curtains frame the views of the surrounding greenery.

Home in Playa Venao

5.0 out of 5 average rating, 40 reviews

Nearly Oceanfront: Blue 3 Bedroom Spacious Villa

Villa-33, your exquisite retreat nestled within Blue Playa Venao. Discover a tropical paradise of stunning beaches. Embark on endless adventures just a short walk away. This beautiful Villa offers 3 bedrooms and 3 baths. Two of the bedrooms feature queen beds, while the third bedroom has 2 twin beds, ensuring a restful night's sleep for everyone. The living area, kitchen, and terrace are thoughtfully equipped with everything you need to make yourself at home during your fun family getaway.

FamilyLocationBeach

Superhost

A welcoming entrance is framed by vibrant tropical plants, with a pathway leading to a covered porch. The structure features a tiled roof and red steps, providing an inviting transition from the outdoors to the interior space.

Home in Pedasí

4.86 out of 5 average rating, 22 reviews

Peaceful Pedasi

Peaceful Pedasi. Get completely away from the city and forget the rest of the world exists. Pedasí is a town and corregimiento situated on the south-eastern tip of the Azuero Peninsula on Panama’s Pacific coast. And although remote enough to feel protected from the stresses of life, Pedasi offers wonderful dining and shopping. Our home offers a full functioning kitchen, large dining space, 5 Bedrooms, 4 Bathrooms, 2 car garage, private pool, and cabana with your own view of the ocean.

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Guest favourite

The house exterior features a warm peach-colored facade with a large white-framed window. Tropical palm trees and vibrant flowering shrubs border the front, providing a refreshing touch to the entrance.

Home in Chitré

4.82 out of 5 average rating, 84 reviews

NinaHouse, spacious and cool house in Chitré.

House just for you, now with a water tank! Up to 7 people, spacious and in one of the best areas of Chitré, quiet and family-friendly, access to the pool in the social area, parks and courts, close to everything: supermarkets, casino, bus; come to Chitre and enjoy typical meals, crafts; plan your walks and visit the best beaches: Pedasi, Venao, Isla Iguana, you can work from NinaHouse with fast internet. We now have air conditioning in the living room for your comfort.

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Guest favourite

A modern tropical home is set amid lush greenery, featuring an expansive deck that connects to a serene pool. Large glass doors provide a view of the inviting interior and allow natural light to fill the space. Mountains and trees frame the backdrop.

Home in Playa Venao

4.98 out of 5 average rating, 83 reviews

Casa Samambaia - sea view tropical paradise w pool

With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

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Guest favourite

Home in Playa Venao

4.9 out of 5 average rating, 83 reviews

Casa Pelicano - Tropical house w pool and seaview

Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

LocationFamilyPets

Guest favourite

The outdoor area features a spacious infinity pool surrounded by a sun deck, complete with lounge chairs. Lush greenery and palm trees can be seen in the background, under a bright blue sky with fluffy clouds, creating a serene outdoor retreat.

Home in Pedasí

4.96 out of 5 average rating, 27 reviews

Villa La Jungla

Escape to this serene, private retreat just minutes from Pedasí, Playa Venao, and stunning beaches. Perfect for 4–8 guests, the home features spacious en-suite bedrooms with quality linens, a fully equipped kitchen, and a newly resurfaced infinity pool. Enjoy total privacy, comfort, and easy access to local adventures. Whether you're here to surf, explore, or relax, this is your ideal home base for a peaceful and memorable stay.

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Guest favourite

Home in Chitré

5.0 out of 5 average rating, 11 reviews

Casa Blu Central Chitre| Sleeps 6| Private Parking

Stay in a newly renovated private home in the center of Chitré with free gated parking, a large backyard, fast Wi-Fi, and space for the whole family. Walk to restaurants, supermarkets and the cathedral while enjoying the comfort of an entire home to yourselves. It combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home.

LocationFamilyDecor

Guest favourite

Home in Las Escobas del Venado

5.0 out of 5 average rating, 14 reviews

Tropical Cozy Cabin / Playa venao

Welcome to our tropical & cozy private cabin, fully furnished and equipped with everything you need for a comfortable stay in Playa Venao. Central location (2 min drive from the beach) Features two bedrooms with 2 single beds each, cozy living room with TV and sofa, fully equipped kitchen, AC in all the rooms, one bathroom and outdoor shower. Also have a nice terrace area with a deck and a comfy dining lounge.

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Top Guest favourite

The exterior of a casita is displayed, featuring a light-colored facade with a red-tiled roof. A silver SUV is parked on a stone pathway that leads to a wooden front door. Lush greenery and palm trees are visible in the background under a partly cloudy sky.

Home in Pedasí

4.91 out of 5 average rating, 35 reviews

A minimalist Casita in Pedasi

Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security

FamilyLocationLong stay

Guest favourite

A colorful hammock hangs between two posts on a wooden terrace, overlooking a vast landscape. The sun sets in the distance, casting a warm glow over the scene, framed by lush greenery and bamboo fencing that adds privacy.

Home

4.95 out of 5 average rating, 22 reviews

Casa Inito - Romantic Getaway

Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****

LocationAmenitiesBeach

Guest favourite

The two-story house is framed by lush greenery, featuring large glass doors that open to a spacious patio. Comfortable seating areas are provided, accompanied by tropical plants. Warm outdoor lighting hangs above, enhancing the inviting ambiance, while views of the sea are visible through the glass.

Home in Cambutal

4.96 out of 5 average rating, 49 reviews

Beach side stay at Casa Blanca

This beautiful two bedroom, double-storey house sits in one of the best locations around, nestled amongst the trees and overlooking a stunning swimming bay in the tropical paradise of Cambutal. Perfectly situated, you will have the warm Pacific Ocean literally on your doorstep, as well as easy access to the highlights of a beach holiday - surfing, swimming, sunsets and more.

LocationFamilySleep quality