
Guesthouse holiday rentals in La Mesa
Find and book unique guesthouse rentals on Airbnb
Top-rated Guesthouses in La Mesa
Guests agree: These guesthouses are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for La Mesa guesthouses
Family-Friendly guesthouses

Lovely Guesthouse in garden setting
We are so grateful to have been able to stay at Gwynn's place, it is so peaceful and lovely. Like a secret garden getaway. We loved all the small touches, and beauty of the space. Gwynn made us feel very welcome and comfortable! The pool is amazing and the outdoor spaces are delightful. Can't wait to stay here again.

Fig Tree Bungalow
This place was great and the owner was very helpful.

The BEST NEST Clean, peaceful, private, affordable
A perfect place for our family during our short stay in San Diego. Clean, comfortable, conveniently located and excellent value. Teri also went above and beyond and we really appreciated her proactive help.

New Guest House - North Park
Lynae’s place was wonderful, as was Lynae! Balboa park right nearby, with gorgeous trails and scenery. Walkable to North Park area which had a fun variety of bars, shops, and restaurants. Lynae was a wonderful host - responsive, kind, flexible - and the home was bright, airy, with gorgeous views. We couldn’t say enough good things about the wall of jasmine walking in. Thank you Lynae for having us in your home!

Retreat house. Nature, Hot Tub, Views!
⭐️⭐️⭐️⭐️⭐️ A Soulful Retreat at Cloud Mountain We had the most peaceful and restorative stay at this guest home in Jamul. My partner was recovering from a hospital stay, and this place offered everything we needed—quiet, nature, and healing energy. The guest house was spotless and cozy, with thoughtful touches. We did yoga on the deck, hiked among boulders, watched every sunrise and sunset, and soaked in the hot tub under the stars. The coastal breeze, birdsong, and privacy made it feel like a true escape. We loved connecting with the warm, welcoming hosts and their family as well as their sweet animal companions both cats and dogs—including a very friendly pig named Violet! We hardly heard a single car or plane during our stay. If you're looking to reconnect with nature, this is the place. We left feeling calm, refreshed, and recharged—and we’ve already planned our return to Cloud Mountain. No need to look any further—this place is something special!!! ⭐️⭐️⭐️⭐️⭐️

Private Guesthouse with Amazing Views
This is a favorite stay in the San Diego area for us for several reasons. When we walk into the studio, we feel at home immediately. The kitchen is stocked with morning coffee and tea supplies. There are welcome sodas in the fridge and snacks in the cupboard. The unit is clean and the bed is comfortable. The cottage feels private with a balcony overlooking a canyon. There is plenty to do within 15-30 minutes of driving time. The location is safe. Kristin, the host, is very responsive. We have had no issues what so ever with any of our stays.

Cosy quiet Guesthouse near SDSU
Desiree is such a sweet host! My husband, five month old, and I stayed in her Airbnb and we very much enjoyed our time. The place was well kept and clean. She had the guest house stocked with all the essentials which made it so nice and convenient. Anytime we had a question or request, she was quick to respond and resolve. The location is close to many great coffee shops, restaurants, and things to do. Glad we found this place and would definitely book it again in the future!!

Private Casita in Great Eastlake Neighborhood
Wonderful spot and perfect for a little weekend visiting family. Super safe and beautiful neighborhood! The bed and linens were extremely comfortable and I slept like a baby. I would definitely stay here again when I’m the area. Thanks David!
Guesthouses with a patio

Gorgeous Guesthouse Poway w/Private Yard
We had a great stay. The place was very clean, private, and beautifully decorated. It felt comfortable and welcoming. Would happily stay here again.

La Jolla Oasis: Ocean, City and Fire Works Views
The space is stunning, spacious with modern decor and beautiful views. Atoosa has anticipated everything you will need to enjoy your vacation, from coffee to complimentary snacks to free weights and gear for the beach. The bed is cozy, and the sheets silky soft. The view from the terrace is lovely and peaceful. Parking is easy, and you are just a quick drive from the cafes and beaches of La Jolla. This gorgeous apartment will surpass your expectations.

Downtown Cottage Minutes to Gaslamp & Petco Park
Great place to stay if you’re in town by yourself. Walkable to the convention center ~20 mins. Easy to get in and out of and quiet at night.

Cozy, Quiet and Private Backyard Studio Escape
I had an absolutely wonderful stay at Stephanie's place! The space was spotless and made me feel right at home. The location was fantastic and the check-in process was incredibly easy. Stephanie was an outstanding host, always quick to respond to any questions. I especially loved the rain shower! I highly recommend this Airbnb to anyone visiting San Diego and would definitely love to stay here again!

New (2022) North Park Abode w/ Roof Deck
A fantastic location in North Park near Balboa Park with gorgeous views from the 2nd floor deck. It made for a gorgeous backdrop for graduation family photos! There are ample nearby restaurant choices for this safe and quiet neighborhood. Comes with a very comfortable bed, and a variety of pillows with an efficient kitchenette.. only wish the shower head streamed more water. Hosts were very gracious and responsive to our requests. I definitly plan to stay here again and have already recommended this awesome place to friends.

Heart of SD | Zoo Nearby | Private Patio | Central
Was quiet but still close enough to all the activities and restaurants. Perfect for a couples getaway.

⭐️Garden studio guesthouse, resort living with pool
We stayed here Feb1-Mar31,2025 What an awesome time we had at Jeff & Andrea‘s casita. They are very gracious hosts. Absolutely gorgeous yard, so private & quiet. Spent our days touring around the area, so much to see and do in Poway. Del Mar Beach was fantastic, Shelby loved the beach. Would recommend this property for long stays. All amenities are top notch. Shopping as well as restaurants are near by. Thank you so much for having us. Ron, Arlene & Shelby

Loft Cabin-Night Cinema+Hot Soaking Tub+Views!
My partner and I had a memorable stay at the guest house loft in spring valley. From the ride down quail canyon with the provided golf cart, to soaking in the outdoor tub, and enjoying an outdoor movie by the fire. We certainly enjoyed starting and ending our day at spring valley. Everything we set out to do was a nice 25-30 minute drive away, to beaches and museums and dining experiences, we certainly didn't mind the short trips as we were able to come back to a beautiful private canyon that the sun would hit just right as we unwind. Allison was very responsive, and all instructions very clear. We recommend this place to our friends and family, and hope to visit again sometime.
Guest house rentals with a washing machine and dryer

Private Guest House for 2 with Kitchen + Laundry
The place was exactly as described! Paid for a place with far less amenities for the exact same price range so definitely recommend this one!

The Happy Family * 2 playhouses near SDSU!
We loved our stay. From the beginning, Jessica was very responsive and friendly. The place was exactly as pictured. Jessica put so much thought into the small details that many other places don't think about. There was a pack and play for my almost 2 year old, but what stood out was the memory foam mattress insert and she provided tiny linens, pillow, and blankets. I've stayed at other places where they literally only had the pack and play and that was it. We were told to bring our own linens. My daughter used the toddler cot which also had linens and blankets. My kids loved the playhouses outside. They swept the outside area of any leaves every day. Pretty genius of Jessica to provide kid brooms to help keep her place clean. Now if only I can convince them to clean when we're at home! We would definitely stay again or try the larger main house if we come back.
*BEAUTIFUL* Sunny Home in Golden Hill
Great stay - the property was just as listed and had everything you would need for your stay. Would definitely recommend.

"Glam Farmhouse dream cottage"🏠🌠
This was my second time staying here, and it was just as great as the first. The place is spacious, comfortable, and has everything I needed for a smooth and relaxing stay. It’s well-equipped and very convenient. Benito made everything simple and stress-free, as always—his hospitality is much appreciated. I’m already looking forward to coming back!

Modern mountain guest house. Incredible views
This was a great house! The kitchen is stocked with the basics plus plenty of coffee, creamer, etc. and a basket of snacks! Water dispenser is also great. Loved everything and would absolutely stay here again and highly recommend it! Thank you Bonnie!

Clean Cozy Private Guesthouse - Central San Diego
This airbnb was very nice for two people. It was a perfect space with a spot on the driveway for one car. Walking in, the airbnb was clean and smelled really good. There was plenty of amenities and our host Frank was friendly and responsive. We would book again!

Cozy Cottage 1/2 mile to North Park close to dtwn
Excellent place. We loved the location relative to the sites we wanted to see. Free parking, laundry, very well stocked kitchen, comfortable bed. We were very comfortable and happy here. And as a host Wendy was phenomenal. One of the most responsive hosts I’ve had the pleasure of connecting with on Airbnb. Thank you Wendy!!!

Quaint Craftsman#2- Walkable, Parking, EV Charging
This airbnb was clean, comfy, and had a lot of great amenities available. I liked that it was in walking distance of a lot of shops and restaurants. Christina was a great host, friendly and responsive. She provided good suggestions for things to do in the area. I would recommend this listing anyone looking to stay in San Diego.
Quick stats about guesthouse rentals in La Mesa
Total rentals
80 properties
Nightly prices starting at
$77 AUD before taxes and fees
Total number of reviews
5.2K reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with a pool
10 properties have a pool
Destinations to explore
- San Diego Holiday rentals
- La Joya Holiday rentals
- Palm Springs Holiday rentals
- Anaheim Holiday rentals
- Stanton Holiday rentals
- Los Angeles Holiday rentals
- Santa Monica Holiday rentals
- San Fernando Valley Holiday rentals
- Channel Islands of California Holiday rentals
- Southern California Holiday rentals
- Las Vegas Strip Holiday rentals
- Henderson Holiday rentals
- Rentals with a fireplace La Mesa
- Family-friendly rentals La Mesa
- Rentals with breakfast La Mesa
- Rentals with an EV charger La Mesa
- Private suite rentals La Mesa
- Apartment rentals La Mesa
- Rentals with beach access La Mesa
- Rentals with a washing machine and dryer La Mesa
- Kid-friendly rentals La Mesa
- Rentals with a beach view La Mesa
- Pet-friendly rentals La Mesa
- Rentals with pools La Mesa
- Rentals with a fire pit La Mesa
- Rentals with outdoor seating La Mesa
- Rentals with a hot tub La Mesa
- House rentals La Mesa
- Fitness-friendly rentals La Mesa
- Smoking-friendly rentals La Mesa
- Rentals with a patio La Mesa
- Guesthouse rentals San Diego County
- Guesthouse rentals California
- Guesthouse rentals United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Tijuana Beach
- Pacific Beach
- Coronado Beach
- La Misión Beach
- SeaWorld San Diego
- Coronado Shores Beach
- Oceanside Harbor
- University of California San Diego
- LEGOLAND California
- Black's Beach
- San Diego Zoo Safari Park
- Balboa Park
- Belmont Park
- Pechanga Resort Casino
- Liberty Station
- Moonlight Beach
- Sesame Place San Diego
- Playas Los Buenos
- Playa Popotla
- USS Midway Museum
- Torrey Pines Golf Course