
Guesthouse holiday rentals in La Mesa
Find and book unique guesthouse rentals on Airbnb
Top-rated Guesthouses in La Mesa
Guests agree: These guesthouses are highly rated for location, cleanliness and more.

Private 1 BR Paradise retreat
Private, yet central. It is your exclusive paradise retreat to enjoy from your spacious 1 bedroom guest house located on the lower level of our home. Hang out in the expansive and private backyard with pool, different sitting areas and covered BBQ room. Or maybe a workout in the gym. Centrally located in the Village of La mesa. Just a 1/4 mile jaunt into the quaint village with its numerous assortments of dining options, stores and trolley station. Freeway close to beaches, downtown and airport

NEW construction - Studio by Village of La Mesa
New studio - Attached Dwelling Unit (ADU) with a private entrance. Walking distance to the Village of La Mesa which has several restaurants, shops and a Vons. Very close to SDSU and quick access to multiple freeways that take you to beaches, mountains, SD Zoo, the nightlife in downtown SD (8, 94, 125). Access to shared laundry room, 2 parking spaces and its own outdoor area. AC & heat. WiFi. Netflix, Hulu with live TV, Apple TV, Disney +, Prime Video and HBO Max. Crib and high chair upon request

Stunning Guest House 15 min. from Zoo, Downtown
Stunning guest house that's 15 minutes to San Diego Zoo + downtown San Diego. The cottage is decorated with mid-century and one-of-a kind furniture in a comfy living space overlooking a gorgeous garden. Enjoy the the garden on your private deck, watch TV while relaxing in the handcrafted Nicaraguan rocker or 1950s Danish slipper chair. The cottage also has a comfy queen-sized bed and a full kitchen that's stocked with what you'd need. Oh, and all guests arrive to a homemade loaf of bread.

Private Cottage in Walkable North Park w/AC
Welcome to our charming private Airbnb in vibrant North Park! Enjoy the perfect blend of comfort and convenience for your San Diego stay. Walk to restaurants, coffee shops, art galleries, wine bars, breweries, yoga studios & various boutiques. Nature lovers will adore the nearby Balboa Park with its stunning gardens and cultural attractions. Downtown, Gaslamp Quarter, beaches, and the famous San Diego Zoo are easily accessible. Book and create lasting memories in this dynamic neighborhood.

SDCannaBnB #1 *420 *parking *dog-friendly *hot tub
Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our casita is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our casita has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our casita is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Hilltop Casita Mount Helix
View the sunrise and sunset from this panoramic hilltop casita. Enjoy a charming getaway with sweeping views of the mountains and valleys. Enjoy refreshments on private patio while taking in the sights of palm trees and endless hills. Located 15 miles from the beach and 20 minutes from many major San Diego attractions. Please note: we currently have an outdoor renovation project in process behind the casita. There may be days during your stay in which outdoor work is being performed.

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV
This is your perfect Guest House with a salt & heated pool & hot tub. We are located in a super quiet & very safe neighborhood in beautiful San Diego, 15 minutes drive to beaches, Downtown, La Jolla, Zoo, Stadiums, Sea World, Convention Center + more. Hike next door at Mission Trails & Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo and top quality finishes and furniture. Everything you need for memorable vacation! No smoking or vaping on the property.

Fletcher Hills - modern 1 BR.Easy, no step access.
** 36 hours between check-ins. Thorough cleaning and sanitizing.. Four night minimum stay. Dogs ONLY are welcomed on a case by case basis. They must be house trained and are not permitted on any furniture. If you instant book, you must contact me about your pet within 24 hours. Smoking is permitted in the outside areas - patio, gazebo, yard. Easy freeway access helps any commute to downtown and area attractions. Having your own vehicle is the best way to get around..

Private Garden Studio
Enter through a hidden garden filled with plants into a cute, clean, recently refurbished studio apartment. Although the house sits on a quiet street with abundant free street parking, it is within easy walking distance of craft breweries, cocktail bars, cafes, and some of San Diego's best restaurants, as well as Trolley Barn Park. We're also an easy shot to the zoo, Balboa Park museums, downtown, and the beaches.

Private Studio with a Panoramic View
Escape to Your Hilltop Retreat! Relax in secluded studio. Sip wine by the cozy fire pit or unwind on the patio with a bird’s-eye view. Conveniently located just 15-20 minutes from the beach and downtown, you’re never far from the action. Plus, well-behaved pets are always welcome. Bringing more friends or family along with you? We also have another listing, The Eagles Nest at the same property.

Spacious, private Mt. Helix country style studio
Located in a quiet and lush neighborhood, in hills of La Mesa. This private studio has everything you need to relax and experience the California life: comfy queen size bed, full kitchen, patio, bbq, and fire pit. Within walking distance to Mt. Helix Historic Park for a spectacular 365-degree view of San Diego. You are 20 minutes from the beach, airport, and mountains.

La Mesa Suite
Mi mesa es su mesa, a beautiful newly built home in sunny La Mesa. Easy access to centrally located shopping center, SDSU and up and coming downtown La Mesa. Short drive down the 8 freeway to the mission beach and downtown SD. Includes everything you need in your home away from home while also providing comfort, security and privacy.
Popular amenities for La Mesa guesthouses
Family-Friendly guesthouses

Private Guest House for 2 with Kitchen + Laundry

The Happy Family * 2 playhouses near SDSU!

Modern mountain guest house. Incredible views

Views! Outdoor Cinema• SoakTub +Zoo add-on

*KING BED* Colorful Guesthouse by Downtown

Views•Sauna•SoakTub• Firepit+Zoo add-on

Mid Century Studio Bungalow Near SDSU

PRIVATE VISTA SUITE/ CENTRAL SAN DIEGO 1BED/1BATH
Guesthouses with a patio

Santorini-Inspired Cottage w/ Hot Tub + Views

Free Bikes. 5 min walk to Windensea Beach La Jolla

Amazing Views! Private Hilltop Home with Balcony~

Adorable 1 bedroom house 8 min from La Jolla

La Jolla Oasis: Ocean, City and Fire Works Views

Downtown Cottage Minutes to Gaslamp & Petco Park

The Under-tree Tiny Home Downtown San Diego

SDSU Central Cozy Casita | Fast WiFi | Walkable
Guest house rentals with a washing machine and dryer

Lovely Guesthouse in garden setting

"Glam Farmhouse dream cottage"🏠🌠

Carrie’s North Park Casita, in Heart of San Diego

South Mission Beach Zen-Like Studio

BEAUTIFUL Private Studio

New Guest House - North Park

Clean Cozy Private Guesthouse | Central San Diego

Early 1900's Carriage House w/Views
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | $174 AUD | $175 AUD | $171 AUD | $165 AUD | $184 AUD | $191 AUD | $201 AUD | $178 AUD | $165 AUD | $170 AUD | $170 AUD | $162 AUD |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about guesthouse rentals in La Mesa

Total holiday rentals
Explore 90 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at $71 AUD per night before taxes and fees

Verified guest reviews
Over 6,510 verified reviews to help you choose

Pet-friendly accommodation
Find 10 rentals that welcome pets

Rentals with dedicated workspaces
50 properties have a dedicated workspace

Wi-Fi availability
90 of La Mesa holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests—averaging 4.9 out of 5!
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