
House holiday rentals in La Mesa
Find and book unique houses on Airbnb
Quick stats about house rentals in La Mesa

Total holiday rentals
Explore 340 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at $42 AUD per night before taxes and fees

Verified guest reviews
Over 15,230 verified reviews to help you choose

Family-friendly holiday rentals
220 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 120 rentals that welcome pets

Holiday rentals with a pool
80 properties feature pools

Rentals with dedicated workspaces
220 properties have a dedicated workspace

Wi-Fi availability
340 of La Mesa holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests—averaging 4.9 out of 5!
Top-rated house rentals in La Mesa
Guests agree: These houses are highly rated for location, cleanliness and more.

Family Fun! Game Garage + Big Yard + Free Parking
Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

2 Bed Hidden Oasis | Garden, Laundry, Parking
Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Sunnyside Resort Spa, Beach, Zoo, Arcade
SEND US A MESSAGE FOR SPECIAL OFFER! Imagine booking the most memorable experience with your party! Kick back and relax in a safe, stylish casita. Check in contactless and enjoy! Cozy, comfy, and a perfect base for exploring the city. Cook your own meal in the alluring kitchen or enjoy your meal at the cute dining area outside. Great for family's or trips with friends! The entire guest house is is 5 minutes from SDSU, 15 minutes from the beach and 15 minutes from downtown San Diego! Enjoy

Cozy 4bd Family Home near all SD Attractions!
This sunny, 4bd home located on a private cul de sac in Mount Helix. Perfect for both family vacations & business trips. Conveniently situated near freeways & grocery stores. It’s comfortably furnished with a fully equipped kitchen. We have new beach chairs towels & toys! Pac-n-play available, fast Wi-Fi and smart TVs. The home features a quiet, private fenced backyard, BBQ, & covered patio. There’s plenty of room for kids to play! Please note that parties and events are not allowed.

Cottage in the Garden! New! Modern!
COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Mid-Century Style Family House with Spa
This home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas Desert Inn situated on nearly an acre. Less than 20 minute drive to beaches/Zoo/Sea World/Downtown. With a swimming pool, jacuzzi, and AC. Surrounded by orange, lemon, pomegranate trees and herb garden. No loud parties please, this is a quiet community.

Palm Cottage, San Diego
Palm Cottage sits in the heart of La Mesa Village, San Diego. Enjoy the charm of a historic home with a fully remodeled and stylish interior featuring both Dutch & French doors letting in plenty of sunshine. A large private yard w/ covered outdoor living area creates the ultimate indoor/outdoor lifestyle. You're steps from the local grocery store, village shopping, coffee shops, restaurants, bars and the trolley. You could not ask for a better location!

Cozy 2Bed-Private Parking, Dog Friendly, Big Yard!
Want to stay in a hidden gem away from the hustle and bustle but still close to many San Diegan hot spots? Come stay in this little oasis perfect for small families and groups to get away and relax. Guests will be able to enjoy a 2 bedroom, 1 bath cozy home with a private entrance, private parking, and a beautiful private yard. The property is right off the 8 freeway which makes it convenient to get to wherever you want to go during your stay!

SDSU Beach Cottage
Welcome to our charming SDSU Beach Cottage! Centrally located in a desirable San Diego neighborhood, you're just 10 minutes from many of the city's top attractions. Steps away, you'll find popular local dining, a wine bar, pub, natural market, pizza shop, nail salon, liquor store, and Einstein Bros. Bagels. Enjoy San Diego's best or unwind in our tropical backyard featuring outdoor games and ping pong. Minimum age to book: 25.

Spacious & Fun | 5br, 4.5ba | Hot Tub | Views
Experience sunny San Diego from this 5 bedroom, 4.5 bathroom foothill home. Wake up to panoramic views of the surrounding hillsides and gather in the spacious living and dining rooms. The home is conveniently located just 15-20 minutes from San Diego's famous beaches and top attractions. After a day of exploration, unwind in the backyard area featuring a hot tub, fire pit, pool table, and life-sized chessboard.

Suite Charles Way: A Cozy Fletcher Hills Studio
This newly remodeled spacious studio retreat features a private courtyard with barbecue, kitchenette, a brand-new California King bed, and a reclining love seat with charging ports. Enjoy a relaxed cabana vibe, a charming neighborhood and treetop views with easy access to all your favorite San Diego destinations. Within minutes from Grossmont Sharp Hospital, Grossmont Center, the trolley and Grossmont College.

Sunny & Spacious 3BR Retreat w/ Parking & A/C
Discover your La Mesa retreat! This newly refurbished home offers a perfect blend of comfort and convenience. Enjoy a gourmet kitchen, stylish dining, three bedrooms, two modern bathrooms, and an expansive yard. Explore nearby attractions like the Grossman Center (10-min walk) with shopping and dining, or venture to San Diego's heart (20-min drive). Perfect for families and groups seeking a relaxing getaway.
Popular amenities for La Mesa house rentals
House rentals with a pool

Beautiful 3,000 Sq Ft Tropical Oasis

QUIET HOME -3 Bedroom & Den, + POOL, sleep 8 plus

Upscale Resort House /Views, Saltwater Pool/Spa !

Bright and spacious home with views, pool & spa.

Tropical Oasis: spa, solar heated pool, waterslide

San Diego Pool | Fire Pit | Sunshine | Sleeps 10

Views - Quiet Mt. Helix Home - Pool -Sleeps 11

ModernCoastal I View I Pool ITub
Weekly house rentals

Cozy Mid-Century Charmer | Huge Backyard | Firepit

Santee Gem: Luxe Modern Home, Spacious Backyard

Jacuzzi, Firepit, Sauna & Ice Bath, Rest & Relax

Travel Writer's Pad

The Home with The View

Private cozy house

Impeccable & private: cozy KING BEDS, FUN Patio

The Sand House-Gorgeous 3BR-2B HotTub+FirePit+Turf
Private house rentals

Oliver House in La Mesa

La Mesa Village Spanish Cottage

Golden Hour Bliss: Pool, Hot Tub & Firepit

Tiny Home with a View

Newly Updated & Beautiful 5 bed • 3 bath • Hot Tub

Hot Tub, BBQ, Patio, 4 min SDSU, Central San Diego

Helix Haven

Tiny Home Two w/ Garden View
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | $262 AUD | $277 AUD | $303 AUD | $297 AUD | $326 AUD | $350 AUD | $354 AUD | $299 AUD | $262 AUD | $266 AUD | $277 AUD | $282 AUD |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Destinations to explore
- San Diego Holiday rentals
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- Guesthouse rentals La Mesa
- Rentals with a hot tub La Mesa
- Rentals with pools La Mesa
- Private suite rentals La Mesa
- Family-friendly rentals La Mesa
- Pet-friendly rentals La Mesa
- Rentals with breakfast La Mesa
- Villa rentals La Mesa
- Apartment rentals La Mesa
- Rentals with beach access La Mesa
- House rentals San Diego County
- House rentals California
- House rentals United States
- SeaWorld San Diego
- Coronado Beach
- LEGOLAND California
- Rosarito Beach
- University of California-San Diego
- San Diego Zoo
- Petco Park
- San Diego Convention Center E Ent
- San Diego Zoo Safari Park
- Pacific Beach
- Balboa Park
- Tijuana Beach
- Pechanga Resort Casino
- San Diego State University
- Torrey Pines State Beach
- Ocean Front Walk
- Oceanside City Beach
- Mission Beach
- Anza-Borrego Desert State Park
- Las Olas Resort & Spa
- Moonlight State Beach
- La Misión Beach
- Belmont Park
- Sesame Place San Diego





