
House holiday rentals in La Mesa
Find and book unique houses on Airbnb
Quick stats about house rentals in La Mesa

Total holiday rentals
Explore 320 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at $43 AUD per night before taxes and fees

Verified guest reviews
Over 14,030 verified reviews to help you choose

Family-friendly holiday rentals
210 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 110 rentals that welcome pets

Holiday rentals with a pool
80 properties feature pools

Rentals with dedicated workspaces
190 properties have a dedicated workspace

Wi-Fi availability
320 of La Mesa holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests—averaging 4.9 out of 5!
Top-rated house rentals in La Mesa
Guests agree: These houses are highly rated for location, cleanliness and more.

HotTub & 100+ Game Arcade Family Getaway San Diego
Nearby📍 ✈️ San Diego Airport - 20min drive 🦓 San Diego Zoo – 17 min drive 🌸 Balboa Park – 17 min drive 🐬 SeaWorld – 22 min drive 🏙 Gaslamp Quarter – 20 min drive 🏡 Old Town San Diego – 20 min drive 🏖 Mission Beach – 25 min drive ⚾ Petco Park – 20 min drive 🌄 Mount Helix Park (scenic views) – 8 min drive ☕ Best Coffee: Public Square Coffee House (5 min) 🧭 Best Family Activity: San Diego Zoo (17 min) 🛍 Best Shopping: Grossmont Center (5 min) 🌿 Best Nature Spot: Mount Helix Park (8 min)

Family Fun! Game Garage + Big Yard + Free Parking
Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

Sunnyside Resort Spa, Beach, Zoo, Arcade
SEND US A MESSAGE FOR SPECIAL OFFER! Imagine booking the most memorable experience with your party! Kick back and relax in a safe, stylish casita. Check in contactless and enjoy! Cozy, comfy, and a perfect base for exploring the city. Cook your own meal in the alluring kitchen or enjoy your meal at the cute dining area outside. Great for family's or trips with friends! The entire guest house is is 5 minutes from SDSU, 15 minutes from the beach and 15 minutes from downtown San Diego! Enjoy

5 Bed Zen Oasis | Fire Pit, BBQ, Laundry, Parking
Capture the essence of San Diego in our 3 bedroom house hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 10 guests with beautiful outdoors and garden, fire pit table, BBQ grill, FREE laundry, central A/C and heating, 5 comfortable king and queen size beds, plenty of sheets and towels, 4 large HDTVs, Netflix, Max, Hulu, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Cozy Mid-Century Charmer | Huge Backyard | Firepit
Welcome to our renovated mid-century home in La Mesa! Perfect for family or friend getaways, this quiet retreat offers a spacious living room, full kitchen, and a huge private backyard. Enjoy shooting hoops, playing corn hole, or relaxing by the fire pit under the stars. No shared walls between bedrooms ensure added privacy and comfort. Ideal location close to San Diego’s top attractions while nestled in a peaceful neighborhood. 15 minutes drive to Downtown, Zoo, La Mesa Village & beaches

Classic Mid-Century Mount Helix Home with Views
Located in the exclusive Mount Helix neighborhood of La Mesa, this property is conveniently located near the 8 and 94 freeways for easy access to explore the greater San Diego area. Attractions like the historic Balboa Park with the San Diego Zoo or Sea World are a 15-25 minute drive away. With spacious interior and exterior spaces at the property, though, you may not want to leave. The property includes 4 bedrooms and 2.5 bathrooms with furnished living room, family room and kitchen.

Cottage in the Garden! New! Modern!
COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Mid-Century Style Family House with Spa
This home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas Desert Inn situated on nearly an acre. Less than 20 minute drive to beaches/Zoo/Sea World/Downtown. With a swimming pool, jacuzzi, and AC. Surrounded by orange, lemon, pomegranate trees and herb garden. No loud parties please, this is a quiet community.

Palm Cottage San Diego
Palm Cottage sits in the heart of La Mesa Village, San Diego. Enjoy the charm of a historic home with a fully remodeled and stylish interior featuring both Dutch & French doors letting in plenty of sunshine. A large private yard w/ covered outdoor living area creates the ultimate indoor/outdoor lifestyle. You're steps from the local grocery store, village shopping, coffee shops, restaurants, bars and the trolley. You could not ask for a better location!

Charming La Mesa Home
**Home cleaned and disinfected following COVID-19 guidelines provided by CDC/Airbnb** Charming 3 bed, 1 bath. Feel at home with your own private laundry, full size kitchen, spa like bathroom and private office/workspace. This place is perfect for both work and leisure getaways. Walking distance from stores, shops, restaurants, and parks. 3 minutes from Highways 125, 94, and 8. Centrally located and less than 15 minutes from downtown San Diego.

QUIET HOME -3 Bedroom & Den, + POOL, sleep 8 plus
Welcome to the La Mesa Pool House! Our cozy house in La Mesa is the perfect place to relax and recharge with the family. This house is walking distance to many great La Mesa eateries such as Terra Restaurant and Surf and Soul. We are also located just 10 minutes away from San Diego State University and we are less than 20 minutes from all major attractions in San Diego: downtown, Little Italy, Zoo, Sea World, beaches and more!

SDSU Beach Cottage
Welcome to our charming SDSU Beach Cottage! Centrally located in a desirable San Diego neighborhood, you're just 10 minutes from many of the city's top attractions. Steps away, you'll find popular local dining, a wine bar, pub, natural market, pizza shop, nail salon, liquor store, and Einstein Bros. Bagels. Enjoy San Diego's best or unwind in our tropical backyard featuring outdoor games and ping pong. Minimum age to book: 25.
Popular amenities for La Mesa house rentals
House rentals with a pool

Fletcher Hills luxury, Sunset View, 4 BR, Pool/Spa

Bright Contemporary 5-Bedroom Oasis, Pool and Yard

The Agave House | Mountain Views & Pool

San Diego Pool | Fire Pit | Sunshine | Sleeps 10

San Diego Oasis: Private Pool & Sunny Escape!

Modern Hilltop Home: Roomy, Views, Family-Friendly

Upscale Resort House /Views, Saltwater Pool/Spa !

Tropical Oasis: spa, solar heated pool, waterslide
Weekly house rentals

Bali-Style Tropical Retreat w/sauna & Cabana Bar

La Mesa Retreat | Hot Tub | Fire Pit | Longer stay

Downtown La Mesa gem

New Townhouse | SDSU | La Mesa Village | Hikes

Hot Tub, BBQ, Patio, 4 min SDSU, Central San Diego

Entire House, English garden, Private Driveway

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub

New Mt. Helix Retreat with Views & Patio
Private house rentals

Tiny Home with a View

San Diego Airbnb Luxe: Pool, Office and Fitness

Tiny Home Two w/ Garden View

Helix Haven

Panoramic Ocean View Retreat - Family Friendly

Sleeps 16 | 2 Hot Tubs, Theater, Gym & Mini Golf

Hilltop Family Retreat | Heated Pool & Ocean Views

Panoramic Estate (As seen on reality tv)
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | June | July | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | $266 AUD | $282 AUD | $308 AUD | $259 AUD | $265 AUD | $308 AUD | $360 AUD | $304 AUD | $266 AUD | $271 AUD | $282 AUD | $287 AUD |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Destinations to explore
- San Diego Holiday rentals
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- Las Vegas Holiday rentals
- Scottsdale Holiday rentals
- Palm Springs Holiday rentals
- Big Bear Lake Holiday rentals
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- Long Beach Holiday rentals
- Santa Barbara Holiday rentals
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- Rentals with an EV charger La Mesa
- Guesthouse rentals La Mesa
- Rentals with a hot tub La Mesa
- Rentals with pools La Mesa
- Private suite rentals La Mesa
- Family-friendly rentals La Mesa
- Smoking-friendly rentals La Mesa
- Pet-friendly rentals La Mesa
- Fitness-friendly rentals La Mesa
- Rentals with a fire pit La Mesa
- Rentals with outdoor seating La Mesa
- Rentals with breakfast La Mesa
- Villa rentals La Mesa
- Apartment rentals La Mesa
- Rentals with beach access La Mesa
- Rentals with a patio La Mesa
- Rentals with a washing machine and dryer La Mesa
- Rentals with a fireplace La Mesa
- House rentals San Diego County
- House rentals California
- House rentals United States
- Rosarito Beach
- SeaWorld San Diego
- Coronado Beach
- University of California-San Diego
- LEGOLAND California
- San Diego Zoo
- San Diego Zoo Safari Park
- Petco Park
- San Diego Convention Center E Ent
- Pacific Beach
- Balboa Park
- Tijuana Beach
- Pechanga Resort Casino
- San Diego State University
- Torrey Pines State Beach
- Anza-Borrego Desert State Park
- Oceanside City Beach
- Mission Beach
- Ocean Front Walk
- Las Olas Resort & Spa
- La Misión Beach
- Moonlight State Beach
- Belmont Park
- Sesame Place San Diego





