
Hotel holiday rentals in Mission Bay
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Top-rated hotels in Mission Bay
Guests agree: These hotels are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay hotels
Family-Friendly hotels

Stylish San Diego downtown Suite

Ocean Beach - Bed in a 8-Bed Mixed Dorm

Ocean Beach - Bed in 6-Bed Female Dorm

Pet-friendly Hotel with Free Breakfast and Pool!

Stay Near Top Attractions | Balcony & Pet-Friendly

Ocean Beach - Bed in 6-Bed Mixed Room

3BR Suite w/ Event Space & Resort Amenities Sleep8

Comic-Con 2025! Stay within walking distance!
Hotels with a pool

Recently reno’d escape near the Gaslamp Quarter

A glimpse of the bay & onsite eats at Dock 1953

Iconic Resort in San Diego

San Diego Stay w/ Pool + Free Airport Shuttle

1-Bedroom Hotel Suite - 2 beds

Beachside La Jolla Stay | 1 Unit | Near Shores

Playful escape near games & concerts at Petco Park

Free B’fast & Parking – Minutes to Pacific Beach
Hotels with a patio

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Comic-Con 2026: Spacious King Suite + Sofa Bed

2 bd/2 bth Resort Style Hotel

Nice Property, stay right in SD!

Worldmark Studio Sleeps 4
Destinations to explore
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