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House holiday rentals in Los Santos

Find and book unique houses on Airbnb

Top-rated house rentals in Los Santos

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Guest favourite
A charming patio is visible, featuring colorful hammocks suspended beneath a traditional roof. Lush greenery frames the view, enhancing the serene outdoor space that encourages relaxation. The exterior of the home is simple yet inviting, with wooden accents and large windows.
Home in Playa El Agallito
4.89 out of 5 average rating, 19 reviews

El Refugio: Nature Escape in Chitre

El Refugio at Playa El Agallito, Chitré: Nature Escape: Just 7 minutes from downtown Chitré, El Refugio is a fully equipped countryside home, perfect for disconnecting in a natural setting. Surrounded by mangroves and accommodating up to 8 guests, it offers a unique experience for couples, families or digital nomads. Enjoy bird watching, the peaceful surroundings, and the comfort of our large gazebo. Ideal for those seeking simple relaxation and a close connection to nature. A unique experience

Superhost
A single-story house is nestled beneath a large tree, featuring a tiled roof and a covered parking area. Surrounding greenery includes bushes and ornamental plants, enhancing the natural setting. The house is positioned to provide a sense of privacy and tranquility.
Home in Chitre
4.86 out of 5 average rating, 63 reviews

Country House Like in the City / La Casita

Casa fresca, con árboles y naturaleza. Áreas amplias para descansar. Ubicación céntrica, cerca de malls, restaurantes, estación de buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Ahora, Chitré, tiene un problema con el agua: no está potable; tenemos 50% de lo habitual, a veces estamos sin agua por algunas horas. Por favor, consulten antes de reserar.

A modern single-story home is illuminated at night, showcasing a covered entrance and a smooth driveway. Ambient lighting highlights the exterior design, while large windows provide glimpses of the interior. Surrounding greenery adds to the peaceful atmosphere.
Home in La Arena
4.58 out of 5 average rating, 40 reviews

Kamehouse

Relax with the whole family in this accommodation where tranquility is breathed. A safe, comfortable, beautiful and centrally located place where you can rest without so many complications. It is also a very pleasant place to look at and functional for work issues. The house has 2 bedrooms each with 1 double bed and 1 single bed, that is, each room is suitable for 3 people. The cost that appears on the page is for one, if you want the other room it has an extra cost of $10 per night

Guest favourite
Home in Chitre
5 out of 5 average rating, 6 reviews

Central Chitre Home: Walk to Parque Unión

Casa Blu invites you to enjoy a truly special stay in the heart of Chitré. Recently renewed, it combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home. Create unforgettable moments together, whether it’s a weekend getaway or a longer stay, with everything you need just steps away — shops, restaurants, and all the local charm that makes Chitré such a wonderful place to visit.

Guest favourite
The house exterior features a warm peach-colored facade with a large white-framed window. Tropical palm trees and vibrant flowering shrubs border the front, providing a refreshing touch to the entrance.
Home in Chitre
4.83 out of 5 average rating, 76 reviews

NinaHouse, spacious and cool house in Chitré.

House just for you, now with a water tank! Up to 7 people, spacious and in one of the best areas of Chitré, quiet and family-friendly, access to the pool in the social area, parks and courts, close to everything: supermarkets, casino, bus; come to Chitre and enjoy typical meals, crafts; plan your walks and visit the best beaches: Pedasi, Venao, Isla Iguana, you can work from NinaHouse with fast internet. We now have air conditioning in the living room for your comfort.

A single-story house is presented with a light grey exterior and a terracotta roof. A paved driveway leads to a vehicle parked under a carport. The front yard is well-maintained, displaying a green lawn and flowering plants along the perimeter.
Home in Monagrillo
5 out of 5 average rating, 3 reviews

Chitré - House in Los Perales

Enjoy unforgettable moments in this cozy house in Los Perales, Chitré, Panama. Perfect for families or groups, it offers spacious and comfortable spaces, an equipped kitchen, air conditioning and a terrace ideal for relaxing. Located close to shops, restaurants and beaches. Experience the tranquility of the countryside with the convenience of the city just minutes away. Book your perfect getaway

Guest favourite
Home in Chitre
5 out of 5 average rating, 5 reviews

Beautiful House for Rent in Chitré Centre

Casa espaciosa y equipada en zona céntrica de Chitré. 3 recámaras con A/C, 2.5 baños, Cocina completa, Wifi rápido, Balcones y parking techado. Ideal para familias, grupos o viajes de trabajo. Spacious house, Fully equipped home in central Chitré. 3 A/C bedrooms, 2.5 baths, full kitchen, Fast wifi, Balconies and covered parking. Perfect for families, groups or business trips.

Guest favourite
A single-story house with a red-tiled roof and beige exterior is featured. Two white columns support a covered entrance, and a small plant is positioned near the front door. The driveway is made of concrete, leading up to a well-maintained yard with green grass.
Home in Monagrillo
4.89 out of 5 average rating, 38 reviews

Our Happy Place

Relax with the whole family in this quiet place to stay. It is a single-family residence, in the master bedroom we have a Queen bed (1.50 m x 1.90 m) in the second bedroom we have 2 Twin beds (90 m x 1.90 m). The residence can comfortably accommodate 4 people, however we have a sofa bed and a Pee bed available for 2 additional people. Check the small extra cost for additional people.

Superhost
A welcoming exterior view is presented, featuring a landscaped garden with green shrubs and flowering plants. The white vehicle is parked in a designated area beside the house, which exhibits a blend of colorful walls and a covered entrance.
Home in Chitre
4.7 out of 5 average rating, 23 reviews

Apartment in Chitré

Your family will be close to everything if you stay at this accommodation. With easy access to public or private transportation. It has 2 double beds, mini bar refrigerator, air conditioner, 3-burner gas stove, separate bathroom and parking for your vehicle. Just a few minutes from downtown Chitré. You will have parks, restaurants and endless places to visit nearby.

Guest favourite
A spacious living area is furnished with two orange sofas and a small black coffee table. Natural light filters through sheer curtains, illuminating the neutral-toned walls. A mounted television is visible, and a refrigerator is located in the background, suggesting a welcoming space for relaxation.
Home in Chitre
5 out of 5 average rating, 8 reviews

Centrally located and well equipped with a capacity for 10 people

Very central, steps away from supermarket, banks, hospitals. Large spaces, patio and all the comforts so you can enjoy your stay. Air conditioning in all areas. Comfortable bed capacity for 10 people. We are Pet Friendly. Parking for 2 cars under a roof and up to a third car in the front outside of the house.

Superhost
A spacious terrace is illuminated by soft outdoor lighting, showcasing wooden furniture and two hammocks. Decorative pots with greenery surround the area, enhancing the inviting setting. Columns support the overhang, and large windows provide natural light during the day.
Home in Chitre
4.69 out of 5 average rating, 16 reviews

Chitré: Weliss's House

Your family and friends will be close to everything if you stay in this centrally located accommodation, geographically located in the center of the Chitré District. Quiet and accessible development. Super Carnes supermarket 200 meters away, restaurants in the area, close to the main street (Ave. Pérez).

Top Guest favourite
Home in La Villa de los Santos
4.94 out of 5 average rating, 106 reviews

Spacious house in Villa de los Santos

Comfortable family accommodation in La Villa de Los Santos, with Wi-Fi, A/C, equipped kitchen, patio and parking. Located near supermarkets and plazas. Only 15 minutes from El Rompió and Monagre, 45 minutes from Isla Iguana and 1h 30 minutes from Playa Venao.

Popular amenities for Los Santos house rentals

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  4. Los Santos
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