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Holiday houses in La Mesa District

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Top-rated holiday rentals in La Mesa District

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Cabin in Sona
4.95 out of 5 average rating, 20 reviews

Beachfront Family EcoParadise to Coiba lsl BunkBed

Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Top Guest favourite
Tiny home in El Copé, La Pintada
4.96 out of 5 average rating, 26 reviews

Serena Lodge & Camping - The Cope

Escape to Serena Lodge, a cozy mountain cabin tucked among pine trees in El Copé, Panama. Wake up to birdsong, stunning valley views, and total privacy—just minutes from waterfalls (Las Yayas, Tigrero, Santa Maria, El Harino river, Rio Grande, Chorro Grande) and the Omar Torrijos National Park. Perfect for couples, families, friends, remote workers and nature lovers seeking fresh air, and a true disconnect in the mountains. 🌧️ Rainy Season (May–November) ☀️ Summer Season (December–March) por

Guest favourite
Home in Lagartero
4.89 out of 5 average rating, 35 reviews

Sunrise -Beach Front- king size, tour Coiba Island

Sunrise is a premiere beach house at Lago Bay. Nestled in a garden setting between the beach and lake with walking trails, the Sunrise experience is filled with nature. With a King-sized mahogany bed and spacious living area, it is very comfortable to unwind after Coiba. The kitchen and bathroom are fully equipped with granite counter tops. Sunrise also has a practical work station with Starlink internet. The screen-in porch is great for listening to the ocean or watching the stars.

Cabin in Ola
4.64 out of 5 average rating, 11 reviews

Cabin overlooking Picachos Olá. Near rivers and waterfalls

Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Superhost
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.79 out of 5 average rating, 29 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Guest favourite
An outdoor terrace is furnished with a sectional sofa in neutral tones and a low coffee table. A potted plant with green leaves and colorful flowers adds a vibrant touch. Large glass doors provide a view into the interior space, inviting natural light.
Villa in Lagartero
4.97 out of 5 average rating, 79 reviews

Private Villa & Pool, in Lago Bay, Santa Catalina

A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Guest favourite
Apartment in Santiago
4.92 out of 5 average rating, 13 reviews

Comfortable and safe apartment in downtown Santiago

Apartamento familiar en el centro de Santiago — cómodo, seguro y totalmente equipado Disfruta de una ubicación privilegiada en pleno centro de Santiago de Veraguas, a pocos pasos de la catedral, el parque municipal y la avenida principal. Todo lo que necesitas está caminando: supermercados, farmacias, bancos, tiendas, restaurantes y transporte. Ideal para familias, profesionales, viajeros por trabajo o personas que visitan la ciudad por trámites o eventos.

Superhost
Cottage in El Copé
5 out of 5 average rating, 4 reviews

Green house, spectacular views, cool climate

Escape to Casa Verde, a mountain retreat in El Copé that's perfect for families and groups of up to 8 people. Enjoy a cool climate, spectacular ocean and mountain views, plenty of space to share, and the peace and quiet of being surrounded by nature. The house is fully fenced, making it an excellent choice for bringing pets and enjoying your stay. If you're looking for fresh air, beautiful scenery and a unique getaway in Coclé, Casa Verde is a great choice.

Top Guest favourite
Home in Canto del Llano
4.91 out of 5 average rating, 57 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 324 reviews

Cabin of the Sun in Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favourite
Cottage in Santa Fe
4.9 out of 5 average rating, 21 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Top Guest favourite
A spacious living area is surrounded by large windows, offering panoramic views of the lush landscape. Comfortable seating is arranged in a circular layout, adorned with colorful cushions. A central coffee table is complemented by decorative plants and a warm wooden floor enhances the inviting ambiance.
Farm stay in Santa Fe
5 out of 5 average rating, 23 reviews

Mansion on Organic Farm with Heated Pool

Capacity 32 people - Relax with the whole family and friends in this cosy house on an organic farm with animals, crops, tilapia fishing and coffee. There are rivers, a heated pool and a 120-metre covered terrace for you to celebrate your special occasions.

Popular amenities for La Mesa District holiday rentals