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Holiday houses in La Mesa District

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Top-rated holiday rentals in La Mesa District

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Superhost
A wooden house is surrounded by lush greenery and tall palm trees. The building features a sloped roof and large windows that invite natural light. A well-kept grassy area leads up to the entrance, emphasizing the connection to nature.
Cabin in Santa Catalina
4.77 out of 5 average rating, 266 reviews

"Casa Ardilla" with garden, kitchen and private bathroom

"SQUIRREL HOUSE" It is a house submerged in the green, very spacious and all in wood. Its tranquility and its contact with nature make it unique. The house is located close to "La Punta", the famous wave of Santa Catalina, just 3 minutes walk. Very close to the house there is the possibility of eating in several restaurants and delighting with a rich ice cream in the ice cream shop "La Moncheria". The house has its own bathroom with hot shower, a large and equipped kitchen and a very special balcony.

Guest favourite
A view of the tranquil beachfront area reveals two boats anchored near the shore. The lush green jungle surrounds a rustic property featuring a cozy outdoor seating area under a canopy of palm trees. The calm waters reflect the greenery, creating a serene atmosphere.
Cabin in Sona
4.91 out of 5 average rating, 11 reviews

Beachfront Family EcoParadise to Coiba lsl BunkBed

Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Guest favourite
A thatched-roof gazebo provides shade over a wooden bar counter, accompanied by several wooden stools. Lush vegetation surrounds the structure, with a clear blue sky visible overhead, creating an inviting outdoor space for relaxation.
Townhouse in Santa Catalina
4.88 out of 5 average rating, 136 reviews

North Villa with Rooftop. Full Kitchen!

Fly / Drive - Tour Coiba - Relax at the North Villa! The North Villa has plenty of space. The rooftop patio has furniture, a bar and is perfect for star gazing and birdwatching. Your villa comes with ample bedrooms, fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, charcoal grill, covered parking and dedicated Internet. We offer a free ground shuttle if you fly into the local airstrip. Feel free to message us and learn how to skip the 6hr+ drive!

Guest favourite
An aerial view captures a charming retreat nestled in lush greenery. The red-tiled roof of the cabin stands prominently surrounded by colorful gardens and fruit trees. A winding path leads to the property, with a vehicle parked nearby, highlighting the spacious natural surroundings.
Tiny home in Cocle
4.94 out of 5 average rating, 131 reviews

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains

Hermosa cabaña de dos habitaciones y dos baños , den panorámico ubicada a unos 50 minutos de Penonome, Provincia de Cocle, en el Area del Parque Nacional Omar Torrijos Herrera , temperaturas entre 22 y 25 grados C a orillas del turístico Chorro de las Yayas en la comunidad de Barrigon del Cope, distrito de La Pintada. Agradable ambiente rodeado de árboles frutales y hermosas cascadas. Ideal para disfrutar de la naturaleza y relajarse. Cuenta con internet satelital de rápida velocidad .

Top Guest favourite
An outdoor terrace is furnished with a sectional sofa in neutral tones and a low coffee table. A potted plant with green leaves and colorful flowers adds a vibrant touch. Large glass doors provide a view into the interior space, inviting natural light.
Villa in Lagartero
5 out of 5 average rating, 58 reviews

Private Villa with private pool, in Santa Catalina

A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Top Guest favourite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 183 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top Guest favourite
Home in Canto del Llano
5 out of 5 average rating, 11 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Superhost
A bright lounge area features a corner sofa adorned with neutral-toned cushions and a decorative throw. Large windows allow natural light to flood the space, while a round woven rug lies on the polished concrete floor, adding warmth to the minimalist design.
Home in Santa Catalina
4.84 out of 5 average rating, 31 reviews

Manifest Loft Santa Catalina

The Manifest Loft is a unique and beautiful home in the peaceful coastal village of Santa Catalina in Panama! It offers the perfect blend of modern comfort and tropical charm, making it the ideal spot for your next getaway. This open-concept space features high ceilings, large windows with beautiful views of the tropical green, and a minimalist design that emphasizes natural light and airy comfort.

Top Guest favourite
A contemporary living space is highlighted, with natural light entering through large windows. An inviting sofa is paired with a wooden coffee table. The kitchenette, featuring modern appliances and a breakfast bar, is visible in the background, alongside a green door that adds a vibrant touch.
Bungalow in Santa Catalina
4.97 out of 5 average rating, 144 reviews

OCTOPUS studio

Disfruta de una experiencia con estilo en este alojamiento de encanto, ideal para pareja : acogedor, luminoso y actual . Ubicación fantastica en área privada y a unos paso del centro, playas y lugares de interés. Confortable para largas estadías y teletrabajo. Wifi gratuito, A/C. Kitchenette. Amplia terraza de madera rodeada de exuberante naturaleza, excelente para practicar Yoga y relajarse.

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 306 reviews

Cabin of the Sun in Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favourite
Cottage in Santa Fe
5 out of 5 average rating, 6 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Top Guest favourite
Two unique tiny houses are set amidst lush greenery, with large glass windows allowing natural light to fill the interiors. A stone wall contrasts with the sleek design of one cabin, while hammocks are gently draped outside, inviting relaxation in the tranquil landscape.
Cabin in Santa Catalina
4.99 out of 5 average rating, 67 reviews

Terra Luna Casa 1

Come try our unique and tranquil tiny house concept. Our tiny houses are designed for you to have a comfortable, relaxing and stress free stay. Our houses are located right in between the main town and all the beach and nature spots. One important thing to consider when visiting Santa Catalina are the power outages. Our house does not have a generator for when this occurs.

Popular amenities for La Mesa District holiday rentals