
Holiday houses in La Mesa District
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in La Mesa District
Guests agree: these stays are highly rated for location, cleanliness and more.

Serena Lodge & Camping - The Cope
Escape to Serena Lodge, a cozy mountain cabin tucked among pine trees in El Copé, Panama. Wake up to birdsong, stunning valley views, and total privacy—just minutes from waterfalls (Las Yayas, Tigrero, Santa Maria, El Harino river, Rio Grande, Chorro Grande) and the Omar Torrijos National Park. Perfect for couples, families, friends, remote workers and nature lovers seeking fresh air, and a true disconnect in the mountains. 🌧️ Rainy Season (May–November) ☀️ Summer Season (December–March) por

North Villa with Rooftop. Full Kitchen!
Fly / Drive - Tour Coiba - Relax at the North Villa! The North Villa has plenty of space. The rooftop patio has furniture, a bar and is perfect for star gazing and birdwatching. Your villa comes with ample bedrooms, fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, charcoal grill, covered parking and dedicated Internet. We offer a free ground shuttle if you fly into the local airstrip. Feel free to message us and learn how to skip the 6hr+ drive!

Country House in Olá, rivers, waterfalls, Los Picachos
Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Private Villa & Pool, in Lago Bay, Santa Catalina
A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Santiago city, home w/ spacious living & office
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Casa Colibrí - modern house in the green
Casa Colibri is a beatiful, spacious home in the middle of nature and will make your stay in Santa Catalina perfect. It has a large terrace with a fantastic view into the green where you can relax and listen to the birds. The interior has a lot of natural light and stays cool during the day, in case you need to escape the tropical heat. It is the perfect place for a unique experience in this special town with your friends or family.

Cabin of the Sun in Finca Namuiki by the River
Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

k* Casa Matilde | 2BR Santa Fe Retreat by River
Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

OCTOPUS studio
Enjoy a stylish experience at this charming place, ideal for couples: cozy, bright and modern. Fantastic location in a private area and a few steps from downtown, beaches, and places of interest. Comfortable for long stays and remote work. Free Wi-Fi, A/C, Kitchenette. A large wooden terrace surrounded by lush nature, excellent for practicing yoga and relaxing.

New Luxury Villa - Solar powered
Newly build in Santa Catalina. Perfect for families or groups of friends. The house is located in a new villa community that is walking distance to the beach, trails, shops and restaurants. With a well maintained lush garden it is a private paradise with all the amenities available.

Mansion on Organic Farm with Heated Pool
Capacity 32 people - Relax with the whole family and friends in this cosy house on an organic farm with animals, crops, tilapia fishing and coffee. There are rivers, a heated pool and a 120-metre covered terrace for you to celebrate your special occasions.
Popular amenities for La Mesa District holiday rentals
Other great holiday rentals in La Mesa District

Green house, spectacular views, cool climate

A spectacular apartment in Santiago

Comfortable and safe apartment in downtown Santiago

Adulam Cabin

Cabin overlooking Picachos Olá. Near rivers and waterfalls

Sunset House Playa Pixvae

Cabin with river view

Orange Corner Cottage
Destinations to explore
- Panama City Holiday rentals
- San José Holiday rentals
- Jaco Holiday rentals
- Cahuita Holiday rentals
- Quepos Holiday rentals
- Cobano Holiday rentals
- Bahía Ballena Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Bocas del Toro Province Holiday rentals
- Uvita Holiday rentals
- Rio Hato Holiday rentals
- Ulloa Holiday rentals





