Holiday houses in La Mesa District

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Top-rated holiday rentals in La Mesa District

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite

Cabin in Sona

4.93 out of 5 average rating, 14 reviews

Beachfront Family EcoParadise to Coiba lsl BunkBed

Experience authentic Panama in our family-owned 30-hectare private tropical beachfront paradise. Accessible only by boat (30-min ride from Pixvae or 1:30hr from Santa Catalina). Gateway to Coiba Island, our remote bay offers pristine jungle, diverse wildlife, and breathtaking views. Enjoy kayaking, fishing, and guided eco-tours. Spot howler monkeys, sloths, and rare birds. Savor fresh tropical fruits and local cuisine. Perfect for nature lovers, photographers, and digital nomads (WiFi available)

Superhost

The image captures a charming two-story house surrounded by lush greenery. Hammocks are suspended from columns on the porch, providing shaded relaxation. A large tree offers additional canopy coverage, with natural light filtering through the leaves, creating a peaceful outdoor environment.

Hut in Santiago

4.63 out of 5 average rating, 30 reviews

Casa de playa Reina

Casa frente al mar en Playa Reina, un espacio sencillo, cómodo y tranquilo, perfecto para desconectarse y disfrutar de la naturaleza. Ubicada a la orilla de la playa, ofrece una vista privilegiada de algunos de los atardeceres más hermosos de Panamá. Cuenta con todo lo básico para una estancia confortable y tiene capacidad para hasta 8 personas, ideal para familias o grupos que buscan descanso, privacidad y calma, acompañados por la brisa marina y el sonido del océano. PLAYA REINA TE ESPERA ....

Superhost

A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.

Cottage in Olá

4.85 out of 5 average rating, 27 reviews

Casa de Campo en Olá, ríos, cascadas, Los Picachos

Finca La Terapia hace honor a su nombre, se encuentra entre las montañas del pintoresco pueblo de Olá de Penonomé, en la cual podrás desconectarte del ajetreado día a día de la ciudad. Cuenta con 42 Hectáreas privadas para explorar la naturaleza. El distrito de Olá, se caracteriza por tener lo mas hermosos paisajes Naturales entre los que podemos mencionar, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, entre otros a muy poco minutos de la Finca.

Guest favourite

A thatched-roof gazebo provides shade over a wooden bar counter, accompanied by several wooden stools. Lush vegetation surrounds the structure, with a clear blue sky visible overhead, creating an inviting outdoor space for relaxation.

Townhouse in Santa Catalina

4.88 out of 5 average rating, 138 reviews

North Villa with Rooftop. Full Kitchen!

Fly / Drive - Tour Coiba - Relax at the North Villa! The North Villa has plenty of space. The rooftop patio has furniture, a bar and is perfect for star gazing and birdwatching. Your villa comes with ample bedrooms, fully equipped kitchen (cookware, spices, blender, coffee maker etc), full living area, charcoal grill, covered parking and dedicated Internet. We offer a free ground shuttle if you fly into the local airstrip. Feel free to message us and learn how to skip the 6hr+ drive!

Superhost

A vibrant red house is depicted alongside a thatched-roof gazebo, surrounded by lush green grass. Outdoor dining furniture is visible, providing a space for relaxation. The open sky brightens the scene, enhancing the sense of openness and connection with nature.

Farm stay in Rio Grande

4.78 out of 5 average rating, 9 reviews

Escape to Nature at cabañita de Kaïs !

Welcome to la Cabañita de Kaïs, Eco Farm Stay in Coclé. Located just 10 minutes from the Panamericana in the beautiful province of Coclé, Finca Nora is a peaceful eco-farm where you can enjoy a true countryside experience. Surrounded by nature, our farm offers direct access to friendly animals like goats, cows, and chickens, making it a perfect escape for families and nature lovers alike. Disconnect, breathe, and connect with authentic rural life is easy at this unique and peaceful getaway.

Guest favourite

An aerial view captures a charming retreat nestled in lush greenery. The red-tiled roof of the cabin stands prominently surrounded by colorful gardens and fruit trees. A winding path leads to the property, with a vehicle parked nearby, highlighting the spacious natural surroundings.

Tiny home in Cocle

4.93 out of 5 average rating, 136 reviews

Cozy 2 Bedrooms, el Cope/ Retreat at the Mountains

Hermosa cabaña de dos habitaciones y dos baños , den panorámico ubicada a unos 50 minutos de Penonome, Provincia de Cocle, en el Area del Parque Nacional Omar Torrijos Herrera , temperaturas entre 22 y 25 grados C a orillas del turístico Chorro de las Yayas en la comunidad de Barrigon del Cope, distrito de La Pintada. Agradable ambiente rodeado de árboles frutales y hermosas cascadas. Ideal para disfrutar de la naturaleza y relajarse. Cuenta con internet satelital de rápida velocidad .

Guest favourite

A wooden house is surrounded by lush greenery and tall palm trees. The building features a sloped roof and large windows that invite natural light. A well-kept grassy area leads up to the entrance, emphasizing the connection to nature.

Cabin in Santa Catalina

4.78 out of 5 average rating, 280 reviews

"Casa Ardilla" con jardín, cocina y baño privado

"CASA ARDILLA" Es una casa sumergida en lo verde, muy espaciosa y toda en madera. Su tranquilidad y su contacto con la naturaleza la hacen unica. La casa está situada cerca a "La Punta", la famosa ola de Santa Catalina, a solo 3 minutos andando. Muy cerca de la casa hay posibilidad de comer en varios restaurantes y deliciarse con un rico helado en la heladería "La Moncheria". La casa tiene baño propio con ducha de agua caliente, una cocina grande y equipada y un balcón muy especial.

Guest favourite

A thatched-roof ranch overlooks a swimming pool area, surrounded by vibrant flowering plants. The ranch provides shaded seating, while a hot tub is positioned next to the pool, enhancing the outdoor space's relaxation opportunities.

Villa in Rio Grande

4.94 out of 5 average rating, 82 reviews

Cheerful 3 bedroom countryside Villa with pool.

Forget your worries in this spacious and serene space. This 2 hectares villa includes an 185 square meters house, with 3 air conditioned bedrooms. In addition it includes a swimming pool and 40 square meter ranch. Bedrooms have in total 9 beds, accomodating 12 people. There are 3. 5 bathrooms, internet and hot water. Total perimeter of land is fenced, including an electric gate at the entrance. The price includes the presence of an employee who will support you during your stay.

Top Guest favourite

An outdoor terrace is furnished with a sectional sofa in neutral tones and a low coffee table. A potted plant with green leaves and colorful flowers adds a vibrant touch. Large glass doors provide a view into the interior space, inviting natural light.

Villa in Lagartero

5 out of 5 average rating, 65 reviews

Private Villa & Pool, in Lago Bay, Santa Catalina

A beautiful stand-alone 60 sq mt villa, 1 King bed and 1 queen. King size bed in the master bedroom with black out drapes, Queen size bed and fold out couch in the loft area. Full kitchen, living and dining area, flat screen TV, Bathroom with soaps/shampoos, and rainfall showerhead. Large terrace with views as far as the eye can see, with BBQ, dining table and outdoor sectional sofa. Private swimming pool with seating area, pool lounge chairs, lighted gazebo and sun umbrellas.

Guest favourite

A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.

Villa in El Copé

4.92 out of 5 average rating, 188 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Guest favourite

Home in Canto del Llano

4.87 out of 5 average rating, 31 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Guest favourite

A contemporary living space is highlighted, with natural light entering through large windows. An inviting sofa is paired with a wooden coffee table. The kitchenette, featuring modern appliances and a breakfast bar, is visible in the background, alongside a green door that adds a vibrant touch.

Bungalow in Santa Catalina

4.96 out of 5 average rating, 152 reviews

OCTOPUS studio

Disfruta de una experiencia con estilo en este alojamiento de encanto, ideal para pareja : acogedor, luminoso y actual . Ubicación fantastica en área privada y a unos paso del centro, playas y lugares de interés. Confortable para largas estadías y teletrabajo. Wifi gratuito, A/C. Kitchenette. Amplia terraza de madera rodeada de exuberante naturaleza, excelente para practicar Yoga y relajarse.