Boutique hotel holiday rentals in Saint Louis County

Find and book unique boutique hotel rentals on Airbnb

Top-Rated Boutique Hotels in Saint Louis County

Guests agree: These boutique hotel rentals are highly rated for location, cleanliness and more.

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Guest favourite

A minimalist studio space features large industrial steel-frame windows allowing natural light to fill the room. A dining table with four chairs is positioned near a cozy seating area that includes a gray sofa accented by red pillows. A colorful wall art piece complements the modern design.

Hotel room in St. Louis

4.9 out of 5 average rating, 133 reviews

Chic Ultramodern Studio Loft w/ Designer Features

The Nash Loft is a stunning minimalist studio with 12’ ceilings, a fully-equipped kitchen with black stainless appliances and quartz countertops, a spacious walk-in closet, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, and bright 7’ industrial steel-frame windows with views of the tree-lined street and shops below. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

A spacious room showcases a leather sofa and a wooden coffee table. A large window allows natural light, framing views of greenery. The sleeping area features a bed with crisp linens, and a small kitchenette is visible in the background.

Hotel room in St. Louis

4.74 out of 5 average rating, 108 reviews

The West End by Cortex, Forest Park, BJC & Zoo

Welcome to The West End, your ideal retreat in the heart of the Central West End! Just steps away from charming attractions like forest park. Great amenities are: - Fast and stable fiber internet connection - Communal kitchen with 2 sets of range, ovens, fridges, microwaves, and dishwashers. - Complimentary coffee - Secured Gated Parking $10/Night - Hot Tub - Great patio space with seating and a gas grill - Complimentary Netflix, Hulu, Disney+, and ESPN+, where available and local TV channel

Guest favourite

An open living area features large industrial windows with black frames, allowing abundant natural light. A leather sofa and armchair are positioned around a low wooden coffee table, with an area rug beneath. Exposed brick walls and a ceiling fan add to the modern aesthetic.

Hotel room in St. Louis

4.92 out of 5 average rating, 114 reviews

Chic Ultramodern Loft Suite w/ Designer Features

The Nash Loft is a stunning minimalist one-bedroom suite with 12’ ceilings + bright 7’ industrial steel-frame windows, a spacious open layout, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, an Edison-illuminated community courtyard, and a fully-equipped kitchen with black stainless appliances and quartz countertops. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

Top Guest favourite

A spacious studio features a comfortable bed with a blue patterned duvet and natural light illuminating the area. A fully-equipped kitchen with wood cabinetry and stainless steel appliances complements a stylish seating arrangement with a soft sofa. A decorative rug and fresh flowers add a touch of warmth.

Hotel room in St. Louis

4.94 out of 5 average rating, 126 reviews

Chic Ultramodern Minimalist Studio Loft + Patio

The Nash Loft is a stunning minimalist studio with 12’ ceilings, a fully-equipped kitchen with black stainless appliances and quartz countertops, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, a comfortable workspace with high-speed internet connection, track lighting, and a lovely patio overlooking the courtyard. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

Guest favourite

The exterior of a two-story building is shown, featuring a red brick ground floor and a silver metal-clad upper level. A striped awning extends over the entrance, where a sign indicates the establishment serves wine and craft beers. Two flags are displayed near seating arranged outside.

Hotel room in Alton

4.95 out of 5 average rating, 44 reviews

Three Bedroom River View Guest House-3 Bathrooms

An escape from the ordinary in our River view guest house. On bottom level is an art glass shop offering classes in stained , fused, and mosaic art glass you may partake in at an additional cost. Bicycle built for two available for cycling the national scenic byway. Walk to shops, casino, restaurants, breweries, and concerts. Cruise ship dock is 1/2 mile away. Extend your stay before or after to enjoy taking a stained glass class offered in our shop below as a souvenir of your trip.

Guest favourite

The spacious common area features an open kitchen with a dark granite countertop, blending modern functionality with historic charm. Two large stained glass windows cast colorful light throughout the room, while a grand staircase leads to an upper level, showcasing the building's architectural elegance.

Hotel room in St. Louis

4.98 out of 5 average rating, 49 reviews

Luxury Retreat, Hot Tub,En-Suite Bath, Location+

Discover refined elegance in The Riverfront Suite, where Gothic grandeur meets contemporary comfort. This distinctive retreat showcases original stained glass windows and exotic wood finishes . A plush queen bed and ambient electric fireplace create an intimate atmosphere, while the luxurious en-suite bathroom features heated floors, designer tile work, and a 2-person soaking tub. Take in panoramic city views from the shared rooftop hot tub. Perfect for couples seeking a romantic escape.

Superhost

A bright bedroom is adorned with a light blue wall, creating a serene atmosphere. The spacious bed is covered with a decorative blanket, flanked by crisp white linens. A bedside table and a dresser provide practical storage, while a large window allows natural light to fill the room.

Hotel room in St. Louis

4.86 out of 5 average rating, 753 reviews

Blue Spruce Room Queen Bed at BnB in CWE!

A Lovely room in a historical St. Louis home! The Blue Spruce Room is on the 2nd floor, and has a recently renovated and beautiful bathroom complete with a walk-in rain shower right next to it. The room has a desk, chair, lamp, table, Amazon Fire TV with basically every major streaming App, newly installed hardwood floors, and a Queen sized-bed. The room has two large windows for plenty of natural light with heavy blinds for sleeping in! Full use of the kitchen upstairs is available!

Superhost

The room features a spacious bed adorned with a patterned blanket, complemented by a bright artwork above. A warm lamp provides soft light, and a ceiling fan is visible. The room has light blue walls and two windows dressed with light curtains, enhancing the natural light.

Hotel room in St. Louis

4.86 out of 5 average rating, 799 reviews

The Maple Room Queen Bed at BnB in CWE!

Guest favourite

The spacious studio features high ceilings and large industrial steel-frame windows, allowing natural light to fill the room. A modern sofa and armchairs are arranged around a wooden coffee table. A dining area with seating is visible, complementing the minimalist design.

Hotel room in St. Louis

4.92 out of 5 average rating, 149 reviews

Chic Ultramodern Studio Loft w/ Designer Features

The Nash Loft is a stunning minimalist studio with 12’ ceilings + bright 7’ industrial steel-frame windows, a spacious open layout, stackable washer + dryer, a designer bathroom with black stainless fixtures and frameless glass shower, an Edison-illuminated community courtyard, and a fully-equipped kitchen with black stainless appliances and quartz countertops. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

Guest favourite

The living area features exposed brick walls and large industrial windows, allowing natural light to fill the space. A modern leather sofa is paired with a geometric coffee table, while a dining table with place settings completes the inviting atmosphere. A cozy area rug adds warmth.

Hotel room in St. Louis

4.9 out of 5 average rating, 158 reviews

Gorgeous Ultramodern 2BR Corner Loft + Workspace

The Nash Loft is a stunning corner loft with two spacious bedrooms, two designer bathrooms with black stainless fixtures and frameless glass showers, 12’ ceilings, a comfortable workspace with high-speed internet connection, stackable washer + dryer, an Edison-illuminated community courtyard, and a fully-equipped kitchen with black stainless appliances. Situated along the famous Locust Street in the heart of Midtown, you’ll be steps from SLU, Wells Fargo, BJC, and the Grove.

Superhost

A modern living area features large windows that frame views of surrounding greenery. Four white armchairs are arranged around a central coffee table, complemented by a cozy beige sofa. Soft lighting is provided by a decorative ceiling fixture, enhancing the space's brightness.

Hotel room in Cottleville

Penthouse Suite

Room 301 2 bedroom Queen, King room Oak Street Inn & Lounge, 8 Room Boutique hotel situated in the bustling center of downtown Cottleville. Oak Street Inn & Lounge will offer an elegant restaurant and craft cocktail lounge on the ground floor Indulge in room service from Pink Willow Cafe, or dine in! Come up to the rooftop patio on the third level for a cocktails, small bites and breathtaking views of Cottleville. Look for our Hidden Gem the Speakeasy in the lower level!

A private suite features a large bed with a plaid blanket. The room is furnished with a dresser and has a workspace with a chair in an adjoining area. Natural light filters through the windows, illuminating the decorative fireplace, which adds historical charm.

Hotel room in Saint Charles

4.78 out of 5 average rating, 260 reviews

1st Capitol Mansion Boutique Hotel - Suite 201

This unit is a hotel style unit that is located in the heart of downtown historic St. Charles. It's located right across the street from a coffee shop, wine bar and the oldest local pub in St. Charles. It is just a few blocks away from all of the shopping and restaurants on Main St. The mansion was built in 1902 and still holds all of the charm from back then. This is a private suite with it's entrance from the rear of the building right off the parking lot.