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Hotels in South San Francisco

Find and book unique hotels on Airbnb

Top-rated hotels in South San Francisco

Guests agree: these hotels are highly rated for location, cleanliness and more.

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Superhost
A modern hotel room features a spacious bed adorned with decorative pillows. A sofa sits nearby, complemented by a work station equipped with a chair and a flat-screen television mounted on the wall. Natural light streams in through large windows dressed with sheer curtains.
Hotel room in Downtown / Union Square
4.95 out of 5 average rating, 22 reviews

Ideal location Union Square.

Private HOTEL room w/private bathroom, timeshare hotel property at THE DONATELLO in UNION SQUARE (sleeps 4) in the heart of San Francisco You are not obligated to attend a timeshare presentation. The front desk will require the following in order to get the room key: 1. Refundable security deposit $250 - credit card preferred Bank issued debit cards may be accepted. Sorry Chime, Netspend, Visa Gift etc are not accepted at this time for the deposit 2. Valid photo Government ID - must be 18+

Superhost
Hotel room in Yerba Buena
4.97 out of 5 average rating, 60 reviews

Sophisticated Stay | Cable Cars Tours. Gym

Located on Market Street, Hyatt Regency San Francisco Downtown SOMA is a sophisticated destination hotel close to the city’s most innovatively stimulating sights. Attractions are just nearby: ✔Picturesque picnics at Golden Gate Park ✔Contemporary and modern paintings, photographs, sculptures and designs from the 20th century, all housed at SF MOMA ✔Postcard-worthy shots, at Golden Gate Bridge ✔Beaux-Arts wonder, the Palace of Fine Arts ✔Best views of San Francisco at Twin Peaks

Superhost
The exterior view of The Marker showcases its Beaux-Arts architecture with elegant detailing. Multiple stories feature large windows, illuminated at dusk, creating a welcoming ambiance. The building is framed by trees and streetlights, set against a softly lit sky.
Hotel room in Tenderloin
4.91 out of 5 average rating, 242 reviews

Union Square Steps Away | On-Site Dining + Gym

Steps from San Francisco’s vibrant Union Square, The Marker blends over a century of hospitality with modern elegance. This boutique Beaux-Arts hotel offers curated amenities like PATH water bottles, FloWater stations, and a 24-hour state-of-the-art fitness center. Dine at Tratto, serving rustic Italian dishes and craft cocktails. With concierge service, curbside valet parking, and California Green Lodging certification, The Marker pairs timeless charm with contemporary comfort.

Superhost
A room with two double beds is framed by wooden headboards, featuring crisp white linens. A nightstand with a lamp and a phone is positioned between the beds, enhancing the functionality of the space.
Hotel room in Millbrae
4.87 out of 5 average rating, 106 reviews

Bay Area Escape | Hotel Room. Free Breakfast

If you plan to explore the Bay Area, The Millwood Inn & Suites is a great jumping-off point. This quaint hotel is located in Millbrae, California, only minutes from Bay Area attractions such as the Golden Gate Bridge. It is also only a six-minute drive from San Francisco International Airport, perfect for those flying in! Be welcomed into a world of comfort and convenience after a long day of exploring California's best. ✔ Free breakfast ✔ Free parking ✔ Fitness center

Superhost
Hotel room in North Los Altos
4.68 out of 5 average rating, 87 reviews

Near Stanford Univ + Breakfast. Kitchen. Pool.

Stay minutes from Stanford University, Google, and downtown Palo Alto at Residence Inn Palo Alto Los Altos. Enjoy spacious suites with full kitchens, separate living areas, and free Wi-Fi. Start your day with a complimentary hot breakfast, unwind by the outdoor pool, or keep up with workouts in the fitness center. Steps from shopping, dining, and tech hubs, this pet-friendly hotel offers the perfect blend of convenience, comfort, and Northern California charm.

Superhost
Hotel room in Cupertino
4.76 out of 5 average rating, 172 reviews

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- Hibernate in stylish, loft-inspired rooms or mingle over cocktails & games in brightly-colored common spaces. - Bar features mood lighting and music that changes throughout the day, attracting a lively crowd. - Re:Fuel offers grab-n-go eats at all hours (fitness center's also open 24/7. Coincidence?). - Modern hotel with Stay Safe Amenities including contactless check-in, keyless room entry, enhanced cleaning & disinfecting, and individual room A/Cs.

Top Guest favourite
A comfortable living area features a light-colored sofa with green accent pillows, accompanied by a modern armchair. A round coffee table sits in the center, complemented by a decorative piece. Natural light enters through two windows, framed by soft curtains, highlighting the warm tones of the walls.
Hotel room in Nob Hill
5 out of 5 average rating, 44 reviews

Nob Hill Inn 1 Bedroom Apartment

This 1-bedroom apartment with a living room in the heart of Nob Hill offers the perfect blend of comfort and convenience. What makes this space special is the combination of privacy and space, featuring a separate living area for relaxation and a well-appointed bedroom for restful nights. Located in the prestigious Nob Hill neighborhood, you’ll be steps away from top San Francisco attractions, iconic landmarks, and local dining gems.

Superhost
An outdoor swimming pool is surrounded by several lounge chairs, creating a relaxing space. Palm trees add a touch of greenery, while a shaded seating area with a wicker sofa invites guests to unwind. The clear blue sky complements the tranquil setting.
Hotel room in Milpitas
4.77 out of 5 average rating, 194 reviews

Near Levi’s Stadium + Free Breakfast. Pool. Bar.

Settle into your suite just off I-880—steps from the Great Mall and minutes to Levi’s Stadium and San Jose bites. Wake up to free hot breakfast, chill by the pool, hit the gym, or sip cocktails at the lounge bar. Weeknight buffet? Yep, that’s included too. With modern suites, fast Wi-Fi, and space to relax between Silicon Valley stops, this stay feels more like home—with a few upgrades you won’t find in most Airbnbs.

Superhost
Hotel room in Moss Beach
5 out of 5 average rating, 4 reviews

Near Montara Mountain + Free Breakfast & Parking

Tucked beside a coastal bluff in Moss Beach, Seal Cove Inn offers boutique charm just 30 minutes from San Francisco. Surrounded by cypress trees and steps from Fitzgerald Marine Reserve, this peaceful escape includes daily breakfast, free bike rentals, Wi-Fi, and parking. Explore Half Moon Bay’s beaches, trails, and shops, then unwind with wine on your private patio or by the in-room fireplace.

Superhost
An outdoor pool area features a rectangular swimming pool surrounded by lounge chairs positioned on wooden decking. Palm trees provide shade, while several seating areas with tables and chairs are visible in the background, all set against a modern architectural backdrop.
Hotel room in Mountain View
4.9 out of 5 average rating, 917 reviews

King Bed at Shashi Hotel in Mountain View

Experience our King room type at Shashi Hotel Mountain View, an Urban Resort. Conveniently, located in the heart of the Silicon Valley - walking distance to Shoreline Amphitheatre. Taste incredible cocktails and delicious bites at our Emerald Hour Bar designed by our Michelin-rated Chef. Enjoy complimentary amenities including our outdoor pool, fitness center, sauna and steam rooms.

Superhost
Hotel room in Downtown / Union Square
4.81 out of 5 average rating, 137 reviews

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- Quirky bookish theme, friendly vibe. Literary aficionados will appreciate the onsite book butler if they’re looking for a new read. - Upper Loin location is right in the bar-hopping mix. - Clubby-feel bar with solid in-house eats and live jazz. - Best place in SF to break out that ascot and monocle and show off that English degree Dad begged you not to get.

The Clift Royal Sonesta San Francisco
4.94 out of 5 average rating, 16 reviews

The Clift Royal Sonesta San Francisco

Experience the perfect blend of historic charm and modern style in our newly renovated deluxe king room. Relax in a plush king bed, enjoy a spa-inspired rainfall shower, and stay productive at the sleek work desk. With premium amenities like a mini-bar, Keurig coffee maker, streaming TV, and complimentary WiFi, your stay is both luxurious and convenient.

Popular amenities for South San Francisco hotels

Quick stats about hotels in South San Francisco

  • Total holiday rentals

    Explore 50 holiday rentals in South San Francisco

  • Nightly prices starting at

    South San Francisco holiday rentals start at $199 AUD per night before taxes and fees

  • Verified guest reviews

    Over 310 verified reviews to help you choose

  • Family-friendly holiday rentals

    20 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 40 rentals that welcome pets

  • Holiday rentals with a pool

    20 properties feature pools

  • Rentals with dedicated workspaces

    50 properties have a dedicated workspace

  • Wi-Fi availability

    50 of South San Francisco holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across South San Francisco rentals

Destinations to explore