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Guesthouse holiday rentals in Santo Domingo

Find and book unique guesthouse rentals on Airbnb

Top-rated Guesthouses in Santo Domingo

Guests agree: These guesthouses are highly rated for location, cleanliness and more.

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Guest favourite
A single-story studio is presented with a warm orange exterior and two front windows, framed by black metal bars. A gated fence and small grassy area enhance the inviting entrance, while a paved driveway provides access to the space.
Guesthouse in Santo Domingo
4.95 out of 5 average rating, 37 reviews

Private Cozy Apartment Studio

One bedroom studio, centrally located in the heart of El Millón, Santo Domingo, where comfort, convenience, and warm space offers the intimate feel of a family home, featuring: A private entrance for your complete privacy. Dedicated parking for your convenience and peace of mind. Whether you're visiting for leisure or business, our studio is thoughtfully designed to meet your needs. Remote workers will appreciate the high-speed internet, ensuring uninterrupted connectivity throughout your stay.

Guest favourite
A spacious room features a full bed with crisp white linens, flanked by two bedside lamps. Decorative artwork is displayed on the walls, while a wooden desk and a chair are positioned adjacent to the bed. The original hydraulic tile floor adds character to the space.
Guesthouse in Santo Domingo
4.91 out of 5 average rating, 22 reviews

Centrally located and unique colonial-style studio

Unique space in a 1930s house, with rustic-industrial elements. Elegant room with original hydraulic floor. Large patio with perimeter fence and electric gate. Centrally located, less than 3 kilometers from the Colonial Zone, 2.5 kilometers from the Central Polygon. Hospital, Laundry, Pharmacy, Malecon 1-2 blocks away. 500-600 meters from 2 subway stations, close to museums and restaurants. Updated technology. Smart speaker. Wi-Fi. TV with YouTube, Netflix, Prime Video. Double bed (full size).

Superhost
A cozy bedroom is highlighted by a white bed with a bright yellow pillow. A small vase holds cheerful orange flowers, adding a touch of color to the space. Rich wooden cabinetry can be seen in the background, contributing to the room's inviting atmosphere.
Guesthouse in Santo Domingo Este
4.79 out of 5 average rating, 34 reviews

Cozy 2 BR with BBQ

This 2 bedroom apartment with BBQ private area is truly bright and cozy . It takes 25 minutes to arrive from the airport. The spacious master bedroom has a queen size bed and the very bright single room have two twins bed. You have discount with our car rental services with airport pick-up. The neighborhood is very safe, is private with access control and very clean, there are many restaurants nearby many bars, gyms, movie theaters, shopping malls . The neighbours are lovely and quiet.

Top Guest favourite
A charming white cottage with a red door is framed by lush greenery and tall trees. A covered porch provides shaded seating areas, while large windows offer views of the surrounding garden. The pathway leads to a tranquil outdoor space, enhancing the peaceful atmosphere.
Guesthouse in San Cristóbal
4.95 out of 5 average rating, 42 reviews

Shantii by Live Happii: A Peaceful Paradise

Shantii is a serene 1-bedroom casita tucked among towering bamboo and lush tropical gardens, designed to nurture your mind, body, and spirit. Enjoy quiet moments by the plunge pool, prepare wholesome meals in the fully equipped kitchen, or simply relax and let Nature lull you into deep tranquility. This is your space to unwind, reflect, and reconnect with yourself. Shanti means "Peace", and that's what you're sure to experience here.

Guesthouse in Santo Domingo Este
4.67 out of 5 average rating, 9 reviews

Dorita's little house

Enjoy a quiet, comfortable and private space, where you can rest, work and get to know Santo Domingo. This home is located 35 mins from Boca Chica beach and 15 mins from the National District. It's also less than 5 minutes away. Supermarkets, squares, clinics, fast food restaurants, recreation park, fuel station, shipping agencies and pharmacies. WE DO NOT RECEIVE DIFFERENT PEOPLE AT THE ACCOUNT OWNER

Top Guest favourite
A bright living area features a decorative wall with a warm brick design, complemented by a wooden ceiling. A television is positioned on a simple black console, while a round dining table is adorned with a vase of elegant flowers, adding a touch of nature.
Guesthouse in Santo Domingo
4.96 out of 5 average rating, 80 reviews

Cozy apartment for work / holidays.

Comfortable apartment, on second level, with private parking, ideal for holiday trips, congresses, jobs and others. Close to shopping centers, Recreational park, clinics, universities; 25 minutes from the colonial area. Located in downtown area of the city, in the urbanization El Millón del Distrito Nacional. Peaceful, residential place with access to the main roads of the city.

Guest favourite
A lush backyard features a swimming pool surrounded by greenery and decorative elements. A barbecue grill is positioned on a stone patio, while comfortable seating arrangements invite relaxation. Colorful plants and well-maintained flower beds enhance the serene outdoor setting.
Guesthouse in Residencial Alameda
4.86 out of 5 average rating, 63 reviews

Guesthouse

An oasis of tranquility in the middle of the city. This private area offers safety, comfort and exclusivity, ideal for those looking for a serene and safe environment. Surrounded by nature and with a design designed for wellness, it is the perfect refuge to disconnect from the urban hustle without departing from the convenience of the city. A true urban paradise.

Guest favourite
The exterior of the property features a modern one-story structure with a terracotta roof. Steps lead down to a clear pool, surrounded by well-manicured hedges and lush greenery. Soft lighting highlights the entrance, offering a welcoming presence during twilight.
Guesthouse in Santo Domingo
5 out of 5 average rating, 11 reviews

Guest House w/Pool near the American Embassy

You no longer need to leave the city to feel in the mountains, this is an independent 1 bed 1 bath Guest House in a closed residence with a 10-meter pool shared with the Hosts. With a Coway potable water filter. Supermarkets, Cinema, Shops, and Hair Salon nearby. A few minutes from the center of Santo Domingo and 1.8 km from the American Embassy.

Guest favourite
Guesthouse in Las Caobas
4.88 out of 5 average rating, 17 reviews

Your little corner of peace in SDO

Kick back and relax in this calm, stylish space. “Tu rinconcito de Paz” is an oasis in the middle of the city rush, take some fresh air in our outdoor Gazebo area, enjoy the privacy and security of our small but cozy house. Commercial centers as Carrefour and numerous restaurants are located at 8 minutes away from our spot.

Guest favourite
The outdoor area features a spacious parking lot with several vehicles, surrounded by greenery and landscaped pathways. A basketball court is visible in the background, alongside a multi-level patio area with seating for outdoor gatherings. Palm trees provide shade in this tranquil setting.
Guesthouse in Santo Domingo
4.92 out of 5 average rating, 12 reviews

U.S. Embassy Suites

Have fun with the whole family at this stylish place while taking it easy at a unique and tranquil getaway. Perfect while on the go or for appointments at the U.S. embassy. Guesthouse comes included with access to an olympic style pool, outdoor patio and barbecue grill. Great for evening get togethers and celebrations.

A wide view of a vibrant street lined with historic buildings features a prominent clock tower in the background. Arched doorways and balconies are visible, while pedestrians and birds inhabit the bustling area, showcasing a lively atmosphere.
Guesthouse in Santo Domingo
4.67 out of 5 average rating, 149 reviews

Cozy Separate Room in Santo Domingo Colonial

Estudio-anexo a la casa. Cómodo - espacioso, próximo a la zona colonial, palacio presidencial, parque independencia, Malecon. Primera ciudad del continente americano. Zona más turística de Santo Domingo. Most tourist area of ​​santo domingo! Great for sightseeing

An outdoor terrace is displayed with grey-tiled flooring, featuring a round table surrounded by four black chairs. Two potted plants are positioned on either side, and a large umbrella provides shade, while a distant cityscape is visible against a clear blue sky.
Guesthouse in Santo Domingo Este
4.67 out of 5 average rating, 3 reviews

Mamuchi House 1 inhab. A/C, Zona Franca San Isidro

1 bedroom apartment with a/c, private bathroom, 3rd. Apartment. Ideal for you who are looking for a comfortable space near the Zona Franca de San Isidro and Air Base, you rest in a family environment. Base rate valid for 2 people, one room.

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