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Holiday houses in Santiago

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Top-rated holiday rentals in Santiago

Guests agree: these stays are highly rated for location, cleanliness and more.

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A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.71 out of 5 average rating, 49 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Home in El Espino de Santa Rosa
New place to stay

Cozy Home El Espino | Pool and Family Atmosphere

Lleva a toda la familia a este fantástico lugar con espacios para descansar y disfrutar. Cozy Home en El Espino está dentro de un residencial privado con garita: seguro, tranquilo y de ambiente familiar, rodeado de naturaleza. Disfruta el área social con terraza y piscina de 3 niveles. A pocos metros de la Interamericana. La casa cuenta con 3 habitaciones (2 con A/A) y 2 baños; uno con agua caliente. Cocina totalmente equipada. Tarifa para 4 (máx. 6). Mascotas con costo.

Superhost
Home in Santiago
4.83 out of 5 average rating, 24 reviews

Casa a minutos de Santiago, U Latina, HospChichoF.

Spacious, comfortable and fully equipped house in a strategic location in Santiago. Perfect for all types of guests: families, business travelers, students, people coming to medical appointments or those looking for a quiet and accessible space. The house is located very close to Dr. Chicho Fábrega Hospital, Clínica Norte, U.Latina, Oxford School, shops, supermarkets, pharmacy, restaurants, and minutes from downtown Santiago. A safe place for short and long stays.

Guest favourite
Apartment in Santiago
4.9 out of 5 average rating, 10 reviews

Comfortable and safe apartment in downtown Santiago

Apartamento familiar en el centro de Santiago — cómodo, seguro y totalmente equipado Disfruta de una ubicación privilegiada en pleno centro de Santiago de Veraguas, a pocos pasos de la catedral, el parque municipal y la avenida principal. Todo lo que necesitas está caminando: supermercados, farmacias, bancos, tiendas, restaurantes y transporte. Ideal para familias, profesionales, viajeros por trabajo o personas que visitan la ciudad por trámites o eventos.

Guest favourite
Home in Canto del Llano
4.86 out of 5 average rating, 29 reviews

Peaceful home w/ spacious living & office area

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

A spacious studio is presented, featuring a comfortable sofa and a queen bed with an elegant headboard. A flat-screen TV is mounted on the wall opposite. A small table and chairs are arranged near the sofa, providing a cozy seating area within the bright space.
Apartment in Santiago
5 out of 5 average rating, 5 reviews

Studio Hotel Gran David

This studio is located behind the Hotel Gran David, which is located in a very convenient location (Carretera Panamericana). However, this studio is located on a very quiet area at the back part of the hotel. Although the studio has an independent entrance to that of the hotel, you can still use all the amenities of the hotel (swimming pool and gym), and have easy access to the hotel's two restaurants, pool bar and bar.

A cozy corner of the apartment features a deep-colored sofa paired with a wooden table and two modern chairs. Natural light enters through two windows adorned with light curtains, while a small plant adds a touch of greenery to the space.
Condo in Veraguas Province
4.53 out of 5 average rating, 43 reviews

Departamento 3E - BEST place in town.

Departamento accesible en el centro de Santiago, ubicado a 300m de la terminal de Transporte y a poca distancia de supermercados y negocios. Con buena distribución del espacio, frescos e iluminados y con todos los servicios básicos. Los apartamentos brindan un balance armonioso en medio del va y ven característico del centro, perfecto para estadías de amigos, profesionales, parejas y familia.

A welcoming living area features a comfortable leather sofa and a small dining table with two chairs. Natural light fills the space from sliding glass doors that open to a balcony, enhancing the connection with the outdoors. A kitchenette and a red refrigerator are visible in the corner.
Apartment in Santiago
4.65 out of 5 average rating, 17 reviews

d'rosas apartments 5PA

Enjoy the simplicity of this quiet and central accommodation. Discover comfort in our cozy accommodation in the heart of Santiago, Veraguas. Just a 5-minute walk from downtown, you'll enjoy a well-equipped space that includes all the necessary amenities for a relaxing stay. Ideal for exploring the local culture and resting after a day of adventures. We look forward to seeing you!

The exterior of the cabin is shown, featuring a concrete structure with a sloped roof. Red and gray brickwork is visible, situated in a natural setting with trees and greenery surrounding the area. A clear blue sky fills the background.
Cabin in El Barrito

Espinosa Bungalow

This cabin is surrounded by vegetation, behind it passes a clean water creek in the middle of the courtyard, which can be crossed by a bridge, it is spacious, it is a 2-minute walk from the Los Sabalos River, 25 minutes from Playa Reina, Mariato, 10 minutes from downtown Atalaya. There are paved streets, drinking water.

Guest favourite
A modest exterior view features a white building with dark windows and a welcoming black door. Lush greenery surrounds the entrance, and well-maintained stone pathways lead to the door, highlighting the peaceful outdoor setting.
Home in Santiago
4.82 out of 5 average rating, 22 reviews

2 bedroom house in Santiago

centric, well located, walking distance to downtown. Near the Panama Canal Museum, park Juan Demostenes Arosemana, and the Santiago Cathedral Juan Pablo Apostol. A few meters from central avenue.

A modern one-story home with a flat roof features large windows framed by wooden slats. A well-manicured lawn surrounds the entrance, while a concrete pathway leads to the front door. The exterior is painted in neutral tones, contributing to its contemporary design.
Home in Santiago
4.78 out of 5 average rating, 113 reviews

3BD, 2BTHS, furnished house

House with 3 bedrooms, 2 bathrooms, central, furnished, security booth, kitchen, automatic washing machine, A/A, Wi-Fi, cable TV, new construction in a nice residential area.

Guest favourite
Home in Santiago
5 out of 5 average rating, 9 reviews

Meters from Mall, Supermarkets, Hospital, etc.

Acogedor, espaciosa, wifi, a metros dé Pricemart, farmacias, restaurantes, a 40 minutos de Playa Torio, para familias y grupos de amigos

Popular amenities for Santiago holiday rentals

Frequently Asked Questions

  • Are there family-friendly vacation rentals in Santiago?

    Santiago has more than 20 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • How much does it cost to stay in house rentals in Santiago?

    Experience the best of Santiago with our house rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Santiago?

    Four-legged friends are welcome in Santiago. Choose from more than 30 vacation rentals for guests traveling with pets.

  • Are there vacation rentals with a dedicated workspace in Santiago?

    Yes! Work meets play with ease at over 20 vacation rentals in Santiago featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do house rentals in Santiago have air conditioning?

    Absolutely! We offer over 20 house rentals with air conditioning in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santiago have a kitchen?

    Absolutely! We offer over 20 house rentals with a kitchen in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santiago have wifi?

    Absolutely! We offer over 20 house rentals with wifi in Santiago. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santiago have free parking?

    Absolutely! We offer over 20 house rentals with free parking in Santiago. Enjoy a tailored experience with all the comforts you desire.

Quick stats about holiday rentals in Santiago

  • Total holiday rentals

    Explore 60 holiday rentals in Santiago

  • Nightly prices starting at

    Santiago holiday rentals start at $14 AUD per night before taxes and fees

  • Verified guest reviews

    Over 600 verified reviews to help you choose

  • Family-friendly holiday rentals

    20 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 30 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    40 of Santiago holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Santiago rentals

  • 4.7 Average rating

    Santiago stays receive an average rating of 4.7 out of 5 from guests

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