
Holiday houses in Santa María
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Santa María
Guests agree: these stays are highly rated for location, cleanliness and more.

Pacific View | Jacuzzi, Pool, Views and Alexa
We are a country house for a maximum of 10 people on a fenced 1,000 m² plot at the top of Valle Los Lirios, Las Uvas de San Carlos, which gives a feeling of seclusion. Located in a neighbourhood with 24/7 video surveillance and a security booth. It offers views of the sea, the Antón Valley and forests. Relax in the whirlpool with hydromassage and jets, or swim in the pool. We have hammocks, a barbecue, a ping pong table, a campfire and an Alexa voice assistant. There is parking for a maximum of 6 cars.

Private Pool Oasis in a Tiny Boutique Villa
Eden Ubedi: Your own, small private sanctuary Valle Antón is a 40 minute drive. We are not in Valle Antón Enjoy 150m² of exclusive space featuring a private plunge pool, garden, spa bath, and cinema screen It is one single space: loft-style Discover a destination beyond the usual tourist spots. Try Panama by staying close to real local communities near the highway Our boutique villa for 2 people ensures privacy with No shops or restaurants nearby, beaches and dining are a 5–10 minute drive

CasAna
Fantastic place with open spaces, natural light and fresh air, 2 bedrooms with internal bathroom, terrace to receive the sunrise and sunset, private pool that makes you feel like you are flying, while you can share with friends and family in a group area provided by a spacious deck, enjoy your barbecues on the terrace and kitchen equipped with everything you need Located 10 meters from Playa La Ermita and 12 meters from the entrance to the Valley, and a hop from the Los Camisones Restaurant.

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura
Welcome to one of the nicest villas in Buenaventura, Panama's most luxurious beach resort community. This meticulously kept, spacious, 4 bedroom vacation paradise with additional private guest house and pool will make for unforgettable getaways with family and loved ones. Private baths, multiple dining areas, Sonos indoor/outdoor sound system, gorgeous outdoor areas and high end finishes, furnishings, and appliances throughout make every moment spent in Las Portales one to treasure.

Country House in Olá, rivers, waterfalls, Los Picachos
Finca La Terapia lives up to its name, it is located among the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day to day of the city. It has 42 private hectares to explore nature. The Olá district is characterized by having the most beautiful natural landscapes, among which we can mention Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the property.

Private Beach Studio · Sunset & Nature Views
Designed for comfort, functionality, and a welcoming atmosphere: • Comfortable bed for a truly restful sleep • Air conditioning • Wi-Fi • Kitchen • 2 Bathrooms • Parking Perfect for short stays or longer breaks. Wake up at your leisure, enjoy a relaxing coffee, stroll to the beach, or simply unwind in this space. This place is ideal for: • Romantic getaways • Personal retreats • “Work from the beach” • Escaping the hustle and bustle of the city

Santiago city, home w/ spacious living & office
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Stunning loft in Buenaventura Golf&Beach Resort
Stunning Remodeled Loft in The Buenaventura Golf & Beach Resort, Panama. Nestled within the lush offerings of Buenaventura Beach Resort in Panama, this completely remodeled loft presents a harmonious blend of modern luxury and natural beauty, creating a truly stunning living space. The loft features an open-concept design that maximizes light and airiness. The high ceilings lend an expansive feel, making the space both inviting and luxurious.

Casa Blu Central Chitre| Sleeps 6| Private Parking
Stay in a newly renovated private home in the center of Chitré with free gated parking, a large backyard, fast Wi-Fi, and space for the whole family. Walk to restaurants, supermarkets and the cathedral while enjoying the comfort of an entire home to yourselves. It combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home.

Beachfront Loft in Farallón
Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!

Cabin of the Sun in Finca Namuiki by the River
Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

k* Casa Matilde | 2BR Santa Fe Retreat by River
Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.
Popular amenities for Santa María holiday rentals
Other great holiday rentals in Santa María

A spectacular apartment in Santiago

Mansion on Organic Farm with Heated Pool

Private Oceanfront Villa | Sleeps 14 |Playa Blanca

Casamar | Private pool | Garden

Private house + Beach 400m away + Jacuzzi + BBQ / 10p

Puntarena | 2BR | Steps from The Beach Club

Villa Cecilia - Cosy studio in Penonomé Centro

Farmhouse
Destinations to explore
- Panama City Holiday rentals
- San José Holiday rentals
- Jaco Holiday rentals
- Cahuita Holiday rentals
- Quepos Holiday rentals
- Bahía Ballena Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Bocas del Toro Province Holiday rentals
- Uvita Holiday rentals
- Boquete Holiday rentals
- Rio Hato Holiday rentals
- Ulloa Holiday rentals





