
Holiday houses in Santa Fe
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Top-rated holiday rentals in Santa Fe
Guests agree: these stays are highly rated for location, cleanliness and more.

LaQhia Casa Loros 5
This Panamanium adventure begins nestled in the greenery of a lush rainforest near SantaFe National Park.Your private apartment secluded from the world offers warm air&the scent of greenery&orchids.Sounds of the jungle/tropical birds call daily. LaQhia Eco Retreat has Cayucos Bar/Restaurant.Also a mind body yoga shala offers otehr services.** fees apply Deeper into the rainforest discover hidden cascading waterfalls.Soak in the beauty&relax with nature. *Refer to house manual for more amenities.

Salamanca Loft
Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

Rincon de Cielo Cabin
Enjoy nature and a stylish experience in this accommodation located in downtown Santa Fe and close to rivers, waterfalls and mountains. The property has beautiful views of the mountains and a small lake. The property can accommodate more than two guests upon coordination and for an additional price per person. The cabin is elegant and has a room with A/C, laundry, kitchen and living/dining room. Use of the kitchen and laundry has an additional cost of $10.00

Santiago city, home w/ spacious living & office
Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Cabin of the Sun in Finca Namuiki by the River
Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

k* Casa Matilde | 2BR Santa Fe Retreat by River
Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Orange Corner Cottage
Welcome to our centrally located, newly renovated home within the village of Santa Fe. Easy walking distance to the bus terminal, restaurants, cafes, grocery stores and artisanal markets. Enjoy a hot shower, Starlink Wi-Fi and the easy access, central location. Santa Fe now has a new asphalt road from Santiago as well as a fuel station and various ATMs.

Country house, La Mismísima
La Mismísima is a magical place to disconnect and live a unique experience in the middle of nature. A spacious place that invites you to meditate, read, have a good coffee with a delicious and special climate for photography lovers. It is a country house with the comforts to make you feel at home, with the tranquility and peace that nature gives you.

La Yeguada - Forest Point Cabin
Lleva a toda la familia a este fantástico lugar con muchas zonas para divertirse, totalmente equipada cabaña de campo con cocina amplia, sala de estar con acceso a televisión, hamacas, refrigerador, estufa, agua caliente y todo lo que necesitas para pasar un buen momento alejado del ruido y convivir con la naturaleza.

Mansion on Organic Farm with Heated Pool
Capacidad 32 personas - Relájate con toda la familia y amigos en esta acogedora casa en una granja organica con animales, sembradios, pesca de tilapia, café, rios, contamos con piscina climatizada, terraza techada de 120 mts para que celebres tus ocasiones especiales.

Cabin with river view
Take it easy at this unique and tranquil getaway. Enjoy the unique experience of nature in your bedroom and living room : -) Comfortable cabin. (glamping). Access to the river. Panoramic view. Very quiet, very zen. Massages and osteopathy upon request.

Vergara Cabin Santa Fe
Kick back and relax on this 2 acre ( 1 hectare) private mountain side property, on the Santa Maria River. Equipped with all the amenities you will need to make your stay a home away from home!
Popular amenities for Santa Fe holiday rentals
Other great holiday rentals in Santa Fe

Vida Lotus Jungle Room near Panama City

Villa Jacobo

Casa El Puente

Complete house 312 m²

Land for rent - 42 hectares

THE MOST LUXURIOUS TOWER IN PANAMA TRUMP TOWER

Casa Tamarindo a country side family house

Don Franklin Cabin. Alto de Piedra, Santa Fe.
Frequently Asked Questions
Are there family-friendly vacation rentals in Santa Fe?
Santa Fe has more than 10 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.
How much does it cost to stay in house rentals in Santa Fe?
Experience the best of Santa Fe with our house rentals, starting at about $20 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there pet-friendly vacation rentals in Santa Fe?
Four-legged friends are welcome in Santa Fe. Choose from more than 20 vacation rentals for guests traveling with pets.
Are there vacation rentals with a dedicated workspace in Santa Fe?
Yes! Work meets play with ease at over 10 vacation rentals in Santa Fe featuring dedicated workspaces. Stay connected and productive in your home away from home.
Do house rentals in Santa Fe have a kitchen?
Absolutely! We offer over 10 house rentals with a kitchen in Santa Fe. Enjoy a tailored experience with all the comforts you desire.
Do house rentals in Santa Fe have free parking?
Absolutely! We offer over 10 house rentals with free parking in Santa Fe. Enjoy a tailored experience with all the comforts you desire.
Quick stats about holiday rentals in Santa Fe

Total holiday rentals
Explore 30 holiday rentals in Santa Fe

Nightly prices starting at
Santa Fe holiday rentals start at $28 AUD per night before taxes and fees

Verified guest reviews
Over 920 verified reviews to help you choose

Family-friendly holiday rentals
10 properties offer extra space and kid-friendly amenities

Pet-friendly accommodation
Find 20 rentals that welcome pets

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wi-Fi availability
20 of Santa Fe holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Santa Fe rentals

4.8 Average rating
Santa Fe stays are highly rated by guests—averaging 4.8 out of 5!
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