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Holiday houses in Santa Fe

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Fe

Guests agree: these stays are highly rated for location, cleanliness and more.

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Apartment in Santa Fe
4.67 out of 5 average rating, 3 reviews

LaQhia Casa Loros 5

This Panamanium adventure begins nestled in the greenery of a lush rainforest near SantaFe National Park.Your private apartment secluded from the world offers warm air&the scent of greenery&orchids.Sounds of the jungle/tropical birds call daily. LaQhia Eco Retreat has Cayucos Bar/Restaurant.Also a mind body yoga shala offers otehr services.** fees apply Deeper into the rainforest discover hidden cascading waterfalls.Soak in the beauty&relax with nature. *Refer to house manual for more amenities.

A bright and airy room features two full-size beds with crisp white linens and decorative pillows. A wooden dining table with four chairs is positioned nearby. Fresh towels are neatly arranged on the beds. A small kitchenette is subtly integrated into the space.
Apartment in Los Canelos
4.73 out of 5 average rating, 56 reviews

Salamanca Loft

Este hermoso apartamento esta ubicado en el centro de todo Panamá en la hermosa provincia de Herrera, vía interamericana, a pocos minutos de varias ciudades como Chitré, Aguadulce y Santiago. En un ambiente tranquilo, rodeado de árboles. Si corren con suerte podrán observar desde lejos las hermosas iguanas que se pasean por las ramas mas altas. Pueden apreciar al caer la tarde una hermosa puesta del sol. Justo al frente, hay cafetería, también hay pizzerías a domicilio y restaurantes.

A modern cabin with a unique architectural design is showcased, featuring an orange and stone exterior. A covered porch area provides shelter and views of the surrounding greenery. A gray vehicle is parked in front, illustrating easy access to this welcoming space.
Cabin in Santa Fe
4.73 out of 5 average rating, 15 reviews

Rincon de Cielo Cabin

Enjoy nature and a stylish experience in this accommodation located in downtown Santa Fe and close to rivers, waterfalls and mountains. The property has beautiful views of the mountains and a small lake. The property can accommodate more than two guests upon coordination and for an additional price per person. The cabin is elegant and has a room with A/C, laundry, kitchen and living/dining room. Use of the kitchen and laundry has an additional cost of $10.00

Guest favourite
Home in Canto del Llano
4.91 out of 5 average rating, 44 reviews

Santiago city, home w/ spacious living & office

Spacious and peaceful home in a safe area of Santiago. 4 bedrooms (ideal for families and groups), bright living-dining area and large kitchen to share with family or friends, plus a private office for working comfortably. High-speed Wi-Fi, air conditioning and fans in all rooms, fully equipped kitchen, washer/dryer, and safe for valuables. Self check-in with smart lock, parking for several cars, and a coffee station with board games and karaoke.

Guest favourite
Farm stay in Santa Fe
4.9 out of 5 average rating, 323 reviews

Cabin of the Sun in Finca Namuiki by the River

Spectacular contemporary style villa surrounded by local flowers and woods. The villas design enhances the relationship with the outside environment with panoramic windows which are found in the dining room and kitchen, this offers an awesome view of the mountains and green flora. The villa is located in a organic quiet farm, with abundant vegetation and great presence of birds.

Guest favourite
Cottage in Santa Fe
4.89 out of 5 average rating, 19 reviews

k* Casa Matilde | 2BR Santa Fe Retreat by River

Escape to Casa Matilde, a renovated 100 m² home in Santa Fe de Veraguas. With 2 bedrooms and 3 beds (1 queen & 2 twins), it’s perfect for families or remote workers. Enjoy a bright living room, modern bath with hot water, A/C, and fast Starlink Wi-Fi. Relax by the private creek, explore the river just 200 m away, and take in mountain views—all with total privacy and comfort.

Home in Santa Fe
4.8 out of 5 average rating, 5 reviews

Orange Corner Cottage

Welcome to our centrally located, newly renovated home within the village of Santa Fe. Easy walking distance to the bus terminal, restaurants, cafes, grocery stores and artisanal markets. Enjoy a hot shower, Starlink Wi-Fi and the easy access, central location. Santa Fe now has a new asphalt road from Santiago as well as a fuel station and various ATMs.

Guest favourite
A rural house with a terracotta roof is situated among lush greenery, framed by mountains. A vehicle is parked in front, with a natural landscape extending around the property. Whispering trees and distant hills offer a serene background.
Cottage in Santa Fe
4.92 out of 5 average rating, 13 reviews

Country house, La Mismísima

La Mismísima is a magical place to disconnect and live a unique experience in the middle of nature. A spacious place that invites you to meditate, read, have a good coffee with a delicious and special climate for photography lovers. It is a country house with the comforts to make you feel at home, with the tranquility and peace that nature gives you.

Cabin in Calobre
4.75 out of 5 average rating, 28 reviews

La Yeguada - Forest Point Cabin

Lleva a toda la familia a este fantástico lugar con muchas zonas para divertirse, totalmente equipada cabaña de campo con cocina amplia, sala de estar con acceso a televisión, hamacas, refrigerador, estufa, agua caliente y todo lo que necesitas para pasar un buen momento alejado del ruido y convivir con la naturaleza.

Top Guest favourite
A spacious living area is surrounded by large windows, offering panoramic views of the lush landscape. Comfortable seating is arranged in a circular layout, adorned with colorful cushions. A central coffee table is complemented by decorative plants and a warm wooden floor enhances the inviting ambiance.
Farm stay in Santa Fe
5 out of 5 average rating, 21 reviews

Mansion on Organic Farm with Heated Pool

Capacidad 32 personas - Relájate con toda la familia y amigos en esta acogedora casa en una granja organica con animales, sembradios, pesca de tilapia, café, rios, contamos con piscina climatizada, terraza techada de 120 mts para que celebres tus ocasiones especiales.

A cozy sleeping area features a spacious bed, surrounded by natural wooden walls made from woven materials. A wooden dresser holds neatly arranged towels, with soft lighting creating a serene ambiance. A textured area rug complements the wooden floor.
Cabin in Santa Fe
4.75 out of 5 average rating, 64 reviews

Cabin with river view

Take it easy at this unique and tranquil getaway. Enjoy the unique experience of nature in your bedroom and living room : -) Comfortable cabin. (glamping). Access to the river. Panoramic view. Very quiet, very zen. Massages and osteopathy upon request.

Guest favourite
A contemporary cabana is nestled among lush greenery, showcasing a unique stone accent wall. Large windows offer expansive views of the natural surroundings, complemented by a covered terrace that invites outdoor relaxation.
Home in Las Trancas
4.91 out of 5 average rating, 32 reviews

Vergara Cabin Santa Fe

Kick back and relax on this 2 acre ( 1 hectare) private mountain side property, on the Santa Maria River. Equipped with all the amenities you will need to make your stay a home away from home!

Popular amenities for Santa Fe holiday rentals

Frequently Asked Questions

  • Are there family-friendly vacation rentals in Santa Fe?

    Santa Fe has more than 10 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • How much does it cost to stay in house rentals in Santa Fe?

    Experience the best of Santa Fe with our house rentals, starting at about $20 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Santa Fe?

    Four-legged friends are welcome in Santa Fe. Choose from more than 20 vacation rentals for guests traveling with pets.

  • Are there vacation rentals with a dedicated workspace in Santa Fe?

    Yes! Work meets play with ease at over 10 vacation rentals in Santa Fe featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Do house rentals in Santa Fe have a kitchen?

    Absolutely! We offer over 10 house rentals with a kitchen in Santa Fe. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Santa Fe have free parking?

    Absolutely! We offer over 10 house rentals with free parking in Santa Fe. Enjoy a tailored experience with all the comforts you desire.

Quick stats about holiday rentals in Santa Fe

  • Total holiday rentals

    Explore 30 holiday rentals in Santa Fe

  • Nightly prices starting at

    Santa Fe holiday rentals start at $28 AUD per night before taxes and fees

  • Verified guest reviews

    Over 920 verified reviews to help you choose

  • Family-friendly holiday rentals

    10 properties offer extra space and kid-friendly amenities

  • Pet-friendly accommodation

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    20 of Santa Fe holiday rentals include Wi-Fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Santa Fe rentals

  • 4.8 Average rating

    Santa Fe stays are highly rated by guests—averaging 4.8 out of 5!

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