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Holiday houses in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Home in Costa Esmeralda
4.98 out of 5 average rating, 197 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Guest favourite
An expansive view of a tranquil beach is seen, with soft sandy shores meeting clear turquoise waters. The horizon features a blend of blue sky and distant buildings, while palm trees and shaded cabanas dot the beach area.
Condo in Chame District
4.96 out of 5 average rating, 171 reviews

Exclusive Beachfront apartment 1Hour from Pma City

ESPECTACULAR apartamento de lujo FULL EQUIPADO con 3 recamaras (todas con vista directa al mar), 2 baños completos y medio baño de visita; cuarto y baño de servicio. Finos acabados, cocina 100% de acero inoxidable y aires acondicionados en todo el apartamento de alta eficiencia. Condominio con concepto "Hotel Style Living"; Restaurante y Bar para las noches (de Jueves a Domingo), snack bar en el area de la piscina y un Tiki Bar en la playa, ademas de cancha de Volleyball , Tenis, basketball.

Top Guest favourite
The exterior of the cabin is depicted, featuring a stone wall and a metal roof. A manicured grass area surrounds the structure, with pine trees in the background against a bright blue sky, creating a serene environment.
Cabin in Chicá
4.94 out of 5 average rating, 280 reviews

Horizonte Cabin by Casa Amaya

Take it easy at this unique and tranquil getaway at Cabaña Horizonte. Casa Amaya is a complex of 6 cabins located in Chicá de Chame, a cool climate between 18 and 24 degrees, where you can connect with nature and relax with your partner, friends or family. https://www.airbnb.com/h/miradorbycasamaya https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya We have an electric generator in case of power outages.

Guest favourite
An aerial view reveals a stretch of coastline featuring sandy beaches with a mix of dark volcanic sand and vibrant turquoise water. Lush greenery lines the shore, complemented by residential areas visible in the background, creating a serene and inviting landscape.
Tiny home in San Carlos
4.8 out of 5 average rating, 127 reviews

Cozy beach cabin at Costa Esmeralda.

Cozy private community cabin on a triple space for up to three people located in Costa Esmeralda beach, over the Pacific ocean. Very quiet area with a 2,200 Square meter patio with trees and vegetation. Relax enjoying of the tropical sun, warm temperatures all year long and the ocean breeze. Only 8 minutes away by walk from the closest beach with warm waters and volcanic black sand. 10 minute drive to Coronado (Grocery Stores, restaurants, bakeries, movie theater, malls and much more)...

Guest favourite
The exterior of the house features a charming design with a red-roofed upper level and a welcoming terrace. A small pool is visible in the foreground, surrounded by lush greenery and natural rock formations. Cloudy skies create a serene atmosphere, enhancing the tranquil setting.
Home in El Nancito
4.94 out of 5 average rating, 31 reviews

Mountain Retreat: Peaceful & Private Escape

Escape to tranquility in our beautiful rural retreat near Laguna de San Carlos, Panama. Nestled on a private hectare of lush land, this cozy two-bedroom, two-bath house boasts an open terrace with breathtaking views of the San Carlos mountains. Whether basking in summer sun or enveloped in clouds during the rainy season, you’ll find peace and beauty here. Just a 30-minute drive to Coronado and the stunning beaches of Panama Oeste, it’s the perfect sanctuary for your getaway.

Guest favourite
Apartment in Las Lajas
5 out of 5 average rating, 5 reviews

Stylish & New, a short stroll away from the Beach

Welcome to your beachside escape at the Bambu Beach Haus! This brand-new modern duplex features a spacious king bed, stylish design, and all the comforts of home. Enjoy cooking in the fully equipped kitchen, relax on your private terrace or balcony, and take in the laid-back coastal vibe. Located in a resort-style community just a short stroll from the beach, you’ll also have access to a sparkling saltwater pool, jacuzzi, and cozy bohios—perfect for a relaxing getaway.

Top Guest favourite
Apartment in Chame, Panama
5 out of 5 average rating, 6 reviews

24-hour ocean view in Coronado

Relax in this quiet and elegant space. You can walk to the beach, and you can go to eat a delicious dinner or lunch at nearby restaurants. If you want to go to the gym, we have all the equipment. Go and enjoy the pool, which is lovely and large for swimming. We have ping-pong tables, a pool table, a recreation area, and you have a workspace, and a refreshing view of the sea. We have a room with a queen size bed and a sofa bed.

Guest favourite
A large swimming pool is surrounded by tropical palm trees, appearing inviting under a clear blue sky. Lounge chairs are positioned around the pool area, providing ample space for relaxation. A portion of the pool is shallow, leading toward a landscaped section with greenery.
Apartment in San José
4.84 out of 5 average rating, 152 reviews

B31-Tropical beach paradise, 2R/2B condo, w/pool

Disconnect for a few days from the routine. Have fun with your partner or family in our apartment in Punta Barco Viejo, we have everything you need to be comfortable and have fun in one of the most exclusive areas of the area. We have everything nearby for your best convenience, restaurants, banks, supermarkets ... I´ll deliver a personalized 5 stars attention. Oh and of course, the BEACH 5min by car!

Top Guest favourite
Condo in Nueva Gorgona
4.95 out of 5 average rating, 22 reviews

Gorgeous Beachfront High Floor

Oceanfront escape! Bright 2BR/2BA condo with floor-to-ceiling windows, modern kitchen, and private balcony overlooking the turquoise sea. Relax in the spacious living area, enjoy stunning sunsets, or unwind in the stylish bedrooms with en-suite baths. Perfect for couples, families, or remote work with breathtaking views. Steps from the beach, dining & entertainment. Your dream coastal getaway awaits!

Top Guest favourite
A lounging chair is positioned beside a sparkling pool, accompanied by a small table. The table holds a glass of water and a bowl, with a book resting alongside. Lush greenery surrounds the area, adding a serene atmosphere.
Guesthouse in Nueva Gorgona
4.99 out of 5 average rating, 76 reviews

Beautiful Casita-Paradise in Panama, New Gorgona

Fully furnished beautiful one bedroom casita is 500 sq. feet with an open living/dining concept. Fully equipped kitchen with new appliances and granite countertops. King size bed in bedroom and offers plenty of storage. Hide-a-bed in living room sleeps 2. **A great property for groups as we have two casitas and two studios on the property. Rent all four and have the place to yourself!

Guest favourite
A bright living area features a comfortable sofa and a glass coffee table topped with a decorative plant. Bar stools are positioned at a kitchen counter, and a dining table accommodates seating. Large windows allow natural light to enhance the open space.
Condo in Nueva Gorgona
4.97 out of 5 average rating, 149 reviews

Spectacular Beach Apt-PH Royal Palm-Gorgona

FIRST LINE TO THE SEA WITH DIRECT ACCESS TO THE BEACH FROM THE PH POOLS. Spectacular apartment overlooking the ocean and Chame Hill, fully furnished for your family to enjoy. The PH has two social areas with 4 swimming pools, a sauna, a gym, a children's play area, a barbecue area, and 3 multipurpose courts. The PB social area has direct access to the sea. UP TO ONE (1) PET IS ACCEPTED.

Top Guest favourite
A spacious exterior view of the loft @ Londolozi showcases a two-story structure with a red-tiled roof. Large glass doors open to a patio area with lounge chairs and a hammock, surrounded by lush greenery and mountains in the background.
Cottage in Sorá
4.95 out of 5 average rating, 114 reviews

Luxury Private Cottage in Altos del Maria

This property is situated within the gated community of Altos del Maria. Surrounded by lush forest and rivers, the loft @ Londolozi is for guests who appreciate a sense of luxury while being close to nature. While Altos del Maria enjoys a warm tropical climate, there is a cooling breeze in the mountains that is not often present in the coastal areas.

Popular amenities for Santa Cruz holiday rentals

  1. Airbnb
  2. Panama
  3. Panamá Oeste
  4. Santa Cruz