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Holiday houses in Santa Clara, Panama City

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Top-rated holiday rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Apartment in Panamá
4.94 out of 5 average rating, 109 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Superhost
Condo in Costa del Este
4.75 out of 5 average rating, 4 reviews

Studio Overlooking Panama City and Pacific Ocean

Discover elevated living in Costa del Este with this modern studio at Arcadia Condo Suites—where comfort meets convenience. Designed to cater to business travelers, families, or couples, this spacious and contemporary home offers the perfect balance of comfort and sophistication for both work and leisure. - Bright and spacious 76 m² studio - Breathtaking city and ocean views - Fully equipped, modern kitchen - Pet-friendly accommodations - 24/7 concierge service

Guest favourite
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in San Felipe
4.92 out of 5 average rating, 113 reviews

Loft 3b Old Town Best! It's 150 m2 (492 feet)

Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

Guest favourite
Apartment in San Francisco
4.99 out of 5 average rating, 141 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Guest favourite
A spacious balcony offers a panoramic view of Panama City's skyline, with a backdrop of dramatic clouds and sunlight illuminating the scene. A modern swing chair sits alongside a potted plant, inviting relaxation among the urban landscape.
Apartment in Parque Lefevre
4.91 out of 5 average rating, 35 reviews

Luxury Suite 18th View Coco del Mar Panama

Immerse yourself in the elegance and comfort of this beautiful apartment located in the heart of Panama. With stunning views of the ocean and the city, it is designed to provide you with a unique experience. Equipped with top-notch amenities such as a pool, gym and social areas, this space guarantees a stay full of tranquility, luxury in this haven of tranquility and exclusivity. Your home away from home!

Superhost
The living area features a light blue accent wall and a cozy gray sectional sofa accompanied by a round ottoman. A large window with striped awnings allows natural light to fill the space. Wall art and a small shelf with a clock add functional decor.
Apartment in Distrito de Panamá
4.76 out of 5 average rating, 21 reviews

Hippodrome Suites

Hippodrome Suites is located in a safe gated community in the suburbs of Panama City, just a short drive 🚘 from the Tocumen International Airport (✈️PTY), Santa Maria and Costa del Este Budiness District. City views, 24-hours security and covered parking. It is ideal for resting and working, business trips or layover nights. This condo offers a perfect mix of comfort, convenience, and tranquility.

Guest favourite
A modern living room is depicted, featuring a wall-mounted television above a black media console. Two light-colored armchairs are positioned beside a round coffee table, which is adorned with decorative items. A large window allows natural light and offers views of the surrounding area.
Apartment in Costa del Este
5 out of 5 average rating, 9 reviews

1bd/2Bthrm East Coast-Panama

What are you waiting for to get to know and enjoy Panama? Stay in our modern, furnished and quiet apartment in Costa del Este, where you can enjoy a spectacular view, fast Wi-Fi, a fully equipped kitchen, access to the pool on the top floor overlooking the city and an incredible sunset, gym and more. Surrounded by cafes, parks and everything you need to have the best experience in the city.

Top Guest favourite
The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.
Home in Panamá
4.94 out of 5 average rating, 399 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Top Guest favourite
A spacious living area is highlighted by large windows that offer views of urban high-rises and the distant ocean. A soft, rounded sectional sofa and a plush armchair provide comfort, while a dark area rug anchors the space beneath a sleek coffee table.
Apartment in Costa del Este
5 out of 5 average rating, 25 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Guest favourite
Guesthouse in Panama City
4.88 out of 5 average rating, 248 reviews

Boho Studio - terraza Privada 9 km aeropuerto

Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk in, with organised and clean streets. We have the Cerro Viento Metro station outside at Metromall.

Guest favourite
A private balcony features woven chairs and a glass-topped table. Green ferns are visible hanging from the wall, while the tiled roof of nearby buildings adds a traditional touch to the view.
Loft in San Felipe
4.87 out of 5 average rating, 200 reviews

Corcho rooms #1 - queen rom with a balcony

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant and apartments upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the buildings around are restored and the neighborhood is safe.

Guest favourite
A modern living area is showcased, featuring a light gray sofa positioned across from a flat-screen TV on a wooden console. Two abstract art pieces adorn the walls. Floor-to-ceiling windows offer views of the city skyline, enhancing natural light in the space.
Condo in San Francisco
4.92 out of 5 average rating, 157 reviews

Beautiful Apartment -3 guests with Balcony

Modern Superhost Apartment near Multiplaza- Pool, Gym & Free Parking Enjoy a stylish and comfortable stay in this modern, fully furnished apartment located in San Francisco, Panama City- just minutes from Multiplaza Mall, restaurants, pharmacies, and supermarkets.

Popular amenities for Santa Clara, Panama City holiday rentals

  1. Airbnb
  2. Panama
  3. San Miguelito
  4. Santa Clara