
Guesthouse holiday rentals in Doña Ana County
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Top-rated Guesthouses in Doña Ana County
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Quaint casita for 2
*Sep 2025 New bed/Aug 2024 New A/C mini split* Quiet cul-de-sac and peaceful landing spot within minutes to NMSU and Old Mesilla. Easy access to I-10 and I-25. Close to golf courses, shopping and the beauty of Las Cruces and Mesilla. Private entrance to casita, patio with dining table and a cozy bedroom, bathroom with tub/shower, WiFi, coffee station, refrigerator with small freezer, microwave. Wonderful hiking trails nearby and less than 60 minutes to White Sands National Park and ELP Airport.
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Relax in the ❤️ of Old Mesilla. Close to plaza.
Welcome to Casa de Martiana! This gorgeous casita is located just a few short blocks (about 1/4 mile) from the plaza in Old Mesilla where you will find tons of great restaurants (mostly delicious Mexican food), wineries, bars, unique shopping and fun events. There is a market in the square on Fridays and Sundays with neat jewelry, art and other local treasures. The area is rich in history and culture and has many tales of days when Billy the Kid and Pat Garrett used to wonder the village.
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Ocotillo Casita in Historic Mesilla.
Mesilla STR Permit #0830 We've renovated 90-year-old historic structures to create sustainable, environmental friendly spaces with rainwater harvesting, solar energy, electric solar-powered car charger. This renovated adobe casita is the 2nd structure after our main house. The 3rd is a smaller vacation rental called Yucca Casita. We are within 2 blocks of the historic Mesilla plaza with its farmers market, shops, galleries, restaurants, and walking trails along historic acequias (canals).
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1 king bd with big fenced back yard pets welcome
Casita La Pacana is nestled in the middle of town surrounded by old pecan trees. Feels like the country but is in the middle of town. 1 bedroom, completely renovated casita that has 1 kind bed, a large living room, streaming TVs in both living room and bedroom, full kitchen including a dishwasher and washer/dryer, hardwood floors, authentic Talavera tile, large shower with a bench seat, huge back yard, and ample parking! This little casita has everything to be your home away from home.
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Raven's House
Casita De Cuervo is a beautiful detached casita. This spacious & quiet casita is very close to popular hiking trails and feels remote while being less than 15 minutes from I-25, NMSU, and both hospitals. This home has a full kitchen, king bed, open living room, work nook, bar stool dining, & much more. Dogs are welcome - there is an enclosed side yard with tall walls for your use. Enjoy the sunrise over the Organ Mountains on the back porch and breathtaking sunset views over the city.
FamilyValueHospitality

Desert Peaks Casita
This lovingly remodeled casita just fifteen minutes from downtown Las Cruces is open, spacious, and comfortably equipped for any length stay. Take in the views of the mountains, watch the birds, or relax in the hot tub under the stars. Hike to the Organ Mountains-Desert Peaks National Monument via an arroyo from the casita, take a dip in the pool, or rest in the peaceful and tastefully decorated space. It is a perfect place for a quiet getaway or as a base to explore the area.
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Getaway Guesthouse in Historic Mesilla
Welcome to our cozy guesthouse, just a few blocks away from the Historic Mesilla Plaza. You'll find unique shops, restaurants, bars, and art markets nearby, offering a delightful experience for all your senses! The mouth-watering scents of Chala's Wood Fired Grill and Spotted Dog Brewery will entice you, as they're just around the corner. You'll also hear the bells from one of the oldest churches in the area and enjoy live music from the neighborhood's restaurants and bars.
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Clara's Nest - The Gem of Hacienda de las Cruces
Clara’s Nest is in a 1880's adobe compound with its own private entry, courtyard, original stone floors, handcrafted beams, hand-painted bird & flower motif throughout. The suite features a king bed, cozy loveseat & ottoman in the sleeping area, dining table & 4 chairs, kitchenette with micro, fridge, coffee & tea bar, a separate living room with sofa, TV, private bath. Outer space includes: covered patio, backyard, pool and hot tub area (heated upon request) No stove.
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Cozy Casita w/private patio near Old Mesilla
This adorable Casita is located in a semi-rural area just one mile from Historic Mesilla and 5 min from the interstate. The one bedroom 1 bath casita is perfect for visitors and travelers alike. Furnished with a queen bed, table and chairs and a outfitted kitchenette with microwave/air fry toaster oven/Keurig /double hot plate/ sink and mini-fridge. Also includes Wi-Fi , Smart TV (no cable), mini-split AC/ heater, and a private outdoor patio table and gas grill.
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Historic Mission - Priest's Quarters-1BR, 1Bath
Located near Hatch, New Mexico...the Chile Capital of the World...is an Old Spanish Mission built in 1860. St Francis de Sales stopped being an active church in 1963, but still retains its special flavor unique to southwest New Mexico. Come stay in the Colorado Room located within the Rectory (priest's quarters) on the property. Everyone enjoys a one-of-kind experience here. You will, too.
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Casa Majik
A two bedroom casita with a kitchen. We have a full bath with tub and shower. Very quiet upscale neighborhood with all custom homes on 1 acre lots. Winding streets perfect for walking or biking. Less than 50 feet from the door of Casa Majik is a trail leading to "A" Mountain. Parking is for a maximum of two cars on the property. Restaurants and Memorial Hospital are 2 miles away.
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Rustic Downtown Hideaway
This Rustic guest home has all the amenities, 1 Queen bed, couch sleeps small person or child, and walk-in shower. Inspired by the old west, this guest home has reclaimed wood and tin roof from an old barn in New Mexico. Within walking distance to cafes, restaurants, bars, and shops. Easy private access, keyless entry, and off street parking.
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Popular amenities for Doña Ana County guesthouses
Family-Friendly guesthouses

The Calm Landing - Private stay 5 min from airport
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Guesthouse Fairacre's
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Tranquil Corner | Downtown El Paso Guesthouse
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Shop,Rest,Repeat | Westside Location Near Outlets
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Terra Casita
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Gym, Kitchen, Tesla Charger & 75” TV, Work & Relax
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Beautiful 1 Bedroom Apartment Suite in El Paso Tx!
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North Hills Casita, Weekly & Monthly Discounts
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Guesthouses with a patio

Casita de Colibrí | Hot Tub • Walk to Old Mesilla
LocationBikingGetting around

Private studio w/ scenic view near downtown
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Stylish Casita in the Heart of El Paso
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Modern Studio in Nice Location
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Cozy Guesthouse - Central EPTX
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Cozy one bedroom modern mountain view suite!
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Dream House - Seen On Visit Las Cruces YouTube
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The Loft
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Guest house rentals with a washing machine and dryer

Pool house/Studio
LocationFamilyIndoor spaces

Cozy Modern Casita-Studio!
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No Cleaning Fee; Casita Bougainvillea; EV+Views!
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The Burning Tree Studio
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Cozy loft hideaway near Ft. Bliss & I-10
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A Stylish Casita in El Paso w/Queen Bed + MNT View
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Private 775 sq ft guest home centrally located
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Jackie's Casita
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