Pet-friendly holiday rentals in Cape Girardeau

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Cozy Country Cabin

Escape to a peaceful cabin on 5 wooded acres, tucked down a private lane with just one neighbor. Surrounded by nature, you may spot deer, turkeys, or even an eagle overhead. This cozy retreat offers true “middle of nowhere” serenity while still being conveniently located just 20–30 minutes from Perryville, Marble Hill, Fredericktown, and Jackson, with easy access to Hwy 72. Centrally situated for exploring the region, it’s the perfect rural getaway to relax, unwind, and reconnect with nature.

Tiny House of Paul - Center For Lost Arts

Perfect if you're working or spending time exploring Southern Illinois. Great discount for longer stays. Tiny House of Paul house has a cozy & spacious feel. A large west-facing window looks out onto the forest. Windows in the loft open to tree tops & stars. Private inside. Centrally located on the property of Center For Lost Arts near Cobden, Illinois. Wander the trails at the end of a work day, or relax on the deck after hiking or exploring. Enjoy your time in Southernmost Illinois.

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint

Gray House Cottage - A peaceful, happy place

Gray House Cottage is a safe, quiet, self contained unit Fast WiFi A private entrance, driveway & covered parking No Tobacco, Cannabis or e-cigarettes No pets 1.6 miles to I-55 Exit 105 10 minutes to Jackson MO 15 minutes to Cape Girardeau MO 10 minutes to Procter & Gamble/Mondi plant facilities Minutes away from city central amenities, golf courses, SEMO State University, sports complexes, wineries, unique eateries, casino, Trail of Tears State Park & Mississippi River

Riverside Getaway | Near Campus & Downtown

Experience early-1900s architecture just steps from Cape Girardeau’s riverfront. This historic home blends original character with modern updates for a comfortable, well-located stay. Tall ceilings, classic trim, and natural light create a warm feel, while reliable Wi-Fi and updated finishes make it practical for weekend visits or longer stays. Whether you’re here for the Riverwalk, a campus event, or time downtown, this retreat offers charm and walkable convenience.

Cedar Lake Retreat A

Enjoy a quiet, peaceful, pet-friendly retreat, less than a mile from Cedar Lake boat ramp/kayak launch and Poplar Camp Beach. This cute and comfy duplex is less than 6 miles from Giant City State Park, located in Shawnee National Forest, and just 4 miles from Southern Illinois University-Carbondale. Enjoy fishing, kayaking, and rock-climbing, or hit the Shawnee Wine Trails. If you’re a nature buff or you’re in town for SIU festivities, this is the place for you.

Log Cabin w/ Hot tub - Near Casino & Downtown Cape

THE BEST GETAWAY HERE IN CAPE! Have a relaxing staycation here in Cape Girardeau Perfect for a QUICK GETAWAY for couples, families or friends 5 MINS to the casino, country club and downtown cape Very unique log home with a private bedroom queen size bed, pull-out queen size futon in the living room and twin size hide away SLEEPS 4. Pool table, darts, and a hot tub.There is a large deck and fire pit which has the feel of being in the woods.

Herman’s Cottage on the Corner

This beautifully remodeled 2 bed/1 bath home offering modern comfort and total convenience. Enjoy central air, stylish furnishings, and high-speed internet. The home features keyless entry, a fully fenced backyard, and a BBQ grill perfect for relaxing evenings. Conveniently located near shopping, dining, and local attractions. Fully furnished and move-in ready, this space is ideal for comfortable, hassle-free living.

Unique luxury cabin with fireplace and pond view

Shawnee Pond Retreat is a two-bedroom countryside haven that sits on a ridge in the Shawnee National Forest. Located just outside Alto Pass near numerous vineyards, lakes and hiking trails, it is a perfect destination for friends, couples, or families. Shawnee Hills Wine Trail has 11 wineries nearby. With its impressive bluffs and spectacular trailways, Giant City State Park is just a 15-minute drive.

Happy home for traveling professionals

Keep it simple at this peaceful and centrally-located place. Perfect home for any travel nurses in the area and safe for children as well. Let our home become yours. It’s comfy and cozy. Located on a dead end road, there is very minimal traffic and it is very quiet. You’ll love the neighborhood deer and our big backyard. No cleaning fee! **No cats. I’m sorry.

Modern Queen Suite Near SIU Carbondale

Stay in Suite 3 at Wall Street Suites, a modern queen suite near SIU Carbondale. This newly renovated micro-suite blends industrial charm with stylish urban design. Enjoy a full kitchen, Smart TV, queen bed & updated bath, plus a shared lobby workspace. Perfect for mid-term or monthly stays near SIU East Campus. Note: Access via stairwell.