Holiday houses in Santa Fe River

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Top-rated holiday rentals in Santa Fe River

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Guest favourite
The Glass House features a wooden deck with expansive glass doors, reflecting the warm hues of sunset. The structure is surrounded by large, moss-laden oak trees, contributing to a serene, natural ambiance.
Cottage in Archer
4.93 out of 5 average rating, 99 reviews

The Glass House

*WIFI Now Available * The Glass House was built by local artist, Ira Winarsky. A charming cottage nestled on 12.5 acres just 7 miles from Gainesville. This cozy fully air-conditioned, retreat offers a perfect blend of nature and comfort, featuring a full kitchen, living room, and spacious deck with scenic views for an evening under the stars. Ideal for couples, adventurers, birdwatchers and Gator friends and fans alike. Seeking a peaceful escape? Come unwind and recharge. *LAKE IS CURRENTLY DRY

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Top Guest favourite
The stilt home is framed by a lush green lawn and surrounded by trees. A wooden staircase leads to the entrance, which is highlighted by warm illumination. A flag is displayed on the porch, suggesting a welcoming atmosphere at dusk.
Cabin in Fort White
4.96 out of 5 average rating, 112 reviews

Camp Manatee - Riverfront+Hot Tub+Kayaks+Boat

Camp Manatee is a magical estate situated on approximately 3 acres with over 650 feet of direct Santa Fe River frontage with a stilt home elevated over the ground by 30+ feet. This gives you an incredible vantage point of the expansive property from the home and wrap-around porches. The home is approximately 1,500 square feet with 3 bedrooms and 2 full bathrooms and sleeps (8) people comfortably. We offer complimentary kayaks for guests to use during their stay. Boat and UTV Rentals Available

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Guest favourite
A serene scene of a cypress log home surrounded by lush greenery is reflected in the calm waters of the Santa Fe River. A wooden dock is visible at the water's edge, inviting relaxation amid nature.
Home in High Springs
4.87 out of 5 average rating, 167 reviews

Family Treehouse on The Santa Fe River

Our front yard is the Santa Fe River. Come enjoy a nature retreat in this cypress log home! Right by Tree House spring and nestled between two state parks, but less than five minutes to downtown. Whether you are looking for rest and relaxation or recreation, our home offers both. Take in the scenery and catch your dinner from the riverbank. Recline in the sunshine on our dock (12’ x 12’). Keep an eye out for otters! It is a two hour float downriver to Poe Springs, Rum Island, and Blue Springs.

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Guest favourite
The spacious living area features a vaulted wooden ceiling and large windows that provide ample natural light. Comfortable seating is arranged around a central area rug, with a game pool table positioned prominently. Sliding glass doors lead to an outdoor deck with views of the surrounding nature.
Home in Branford
4.84 out of 5 average rating, 103 reviews

Serenity On The River – Cozy Branford Retreat!

Welcome to our tranquil retreat on the Santa Fe River! Our 2BD, 2BA home offers a peaceful escape for nature lovers and outdoor enthusiasts. Nestled on a lot with direct access to the river, you'll enjoy stunning views from the comfort of the living room or outdoor deck. Watch the sunrise over the river while enjoying morning coffee, or unwind in the evening with a glass of wine as you soak in the sunset. Book your stay today and experience the beauty of the Santa Fe River at our cozy retreat!

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Guest favourite
Two comfortable chairs are positioned on a wooden deck overlooking a calm lake, surrounded by a serene landscape. The expansive water reflects a blue sky, creating a peaceful atmosphere for relaxation and enjoyment.
Home in Melrose
5 out of 5 average rating, 22 reviews

Modern LAKE HOUSE on Lake Santa Fe near Gville/UF

Have fun OR relax at this fully renovated LAKE HOUSE w/BOATHOUSE and raised sunset deck only 30 mins to Gainesville! Sit back and and enjoy the beautiful views of the lake as soon as you enter the home or up close from the hammock swings in the boat house! 3 BR/2 BA plus converted air conditioned garage used as a game room with Ping Pong Table and TV, easily sleeping 8. The backyard offers a large deck with privacy fencing and lush landscaping with direct access to step right into the lake.

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Top Guest favourite
A charming log home is nestled among large trees draped in Spanish moss, with a well-kept grassy area leading to the lake. The porch is visible, and the peaceful water serves as a backdrop, enhancing the natural beauty of the surroundings.
Cabin in Hawthorne
4.97 out of 5 average rating, 174 reviews

Charming Lakefront Log Home

Welcome to your perfect lake retreat! Located on a no public access lake. This charming log home has a private dock and boat ramp suitable for launching your boat for fishing or skiing. There are kayaks on premises for use. This is an ideal location to enjoy North Florida’s lake life with family, friends, or work retreat. Includes a fully stocked kitchen, covered porch, fire pit, gas grill, and WiFi if you feel the need to plug in. NOT suitable for parties or events. NO loud noise, please.

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Top Guest favourite
A serene lakeside view features vibrant pink flowers and lush greenery framing a hammock. The calm, clear waters of the private lake are visible in the background, with two kayaks resting on the shore, creating an inviting space for relaxation.
Cottage in Hawthorne
4.97 out of 5 average rating, 201 reviews

Modern Cottage on Private Spring Fed Lake

Nestled on a gorgeous spring-fed private lake in the woods, our charming cottage is your ideal retreat. Whether you're dreaming of peace and quiet, a romantic getaway, or fun with your kids, this is the place to be! Kayak around the serene lake as you witness breathtaking sunsets, take a dip in the cool water or simply unwind amidst the beautiful surroundings. As night falls, gather around a fire and gaze up at the many stars lighting the sky. Come and create many cherished memories ☀️

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Top Guest favourite
Home in Fort White
4.98 out of 5 average rating, 44 reviews

Santa Fe River Front Getaway-Dog Friendly

Unplug and unwind at our serene riverfront home on the Santa Fe Enjoy your morning coffee on the screened-in porch or watch the river from the floating dock, surrounded by birdsong and wildlife. A perfect reset for nature lovers looking to slow down and reconnect in a calm, well-kept space. The property is located in a residential neighborhood perfect for couples, solo travelers, small group or families looking for quiet recreation on the river. No parties or gatherings are allowed.

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Top Guest favourite
A serene waterway is flanked by lush green trees, creating a tranquil environment. Colorful kayaks in shades of purple, red, and green rest on the calm waters, with a wooden platform visible in the background, offering a launching point for water activities.
Home in Fort White
4.79 out of 5 average rating, 354 reviews

Santa Fe Getaway on Santa Fe River.

We are next door to Rum Island Park which is a swimming spring, kayak and canoe pick up/ drop off/boat ramp location. It is a private cottage. 1 bdr Sleeps 4. 1 Bedroom with a sleeper sofa. You’ll love my place because of the location. The river is in the backyard. You can launch your personal canoe or kayak. Sit by the fire pit or enjoy the deck and cook out with friends and family. We have a no pet policy due to our allergies. Town of High Springs and Gainesville near by

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Top Guest favourite
Dome in High Springs
5 out of 5 average rating, 6 reviews

Soluna GeoDome 2: Stargazing, Springs, Outdoor Tub

Check out our latest handcrafted geodome creation. Tucked into the trees at Soluna Springs, 3 min to Poe, 5 min to Blue, and 12 min to Ginnie Springs, our geodome has everything you need to stay comfortable while being close to nature, and nothing you don’t. Rest on our King organic Birch mattress, stargaze while soaking in our outdoor tub, take a hot outdoor shower after the sauna, fire up the charcoal grill and fire pit, and sit back and relax. This isn’t a hotel. Its a reset.

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Guest favourite
Cabin in Trenton
4.92 out of 5 average rating, 25 reviews

Cozy A-Frame: Hand-Feed Animals on 800-Acre Farm

Escape the ordinary in our stunning A-frame nestled on a massive 800-acre working farm. This isn't just a stay; it’s an immersive wildlife adventure! Wake up to the sights of over 200 animal species right outside your door. From morning coffee to sunset strolls, you’ll have the unique chance to hand-feed and get up close with our friendly residents. Perfect for nature lovers and families seeking a rustic yet magical retreat. Book your unforgettable farm-stay safari today!

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Top Guest favourite
Campervan/RV in Fort White
4.95 out of 5 average rating, 106 reviews

Riverfront RV on a Farm by the Springs

Welcome to The Riverland—where farm meets springs. Relax in our modern RV on the Santa Fe River, surrounded by oak trees, farm animals, and wildlife. Close to Ginnie, Poe, and Blue Springs. Enjoy kayaking, paddleboarding, or horseback riding (message for pricing), then unwind in nature. We also offer a cottage and farmhouse for larger groups. A second RV is coming soon next door, with a privacy fence added for comfort and privacy.

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Popular amenities for Santa Fe River holiday rentals

  1. Airbnb
  2. United States
  3. Florida
  4. Santa Fe River