
Family-friendly holiday rentals in Saint Charles
Find and book unique family-friendly homes on Airbnb
Quick stats about holiday rentals that are family-friendly in Saint Charles

Total holiday rentals
Explore 150 holiday rentals in Saint Charles

Nightly prices starting at
Saint Charles holiday rentals start at $113 AUD per night before taxes and fees

Verified guest reviews
Over 12,550 verified reviews to help you choose

Pet-friendly accommodation
Find 80 rentals that welcome pets

Rentals with dedicated workspaces
90 properties have a dedicated workspace

Wi-Fi availability
150 of Saint Charles holiday rentals include Wi-Fi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Saint Charles rentals

4.8 Average rating
Saint Charles stays are highly rated by guests—averaging 4.8 out of 5!
Top-rated family-friendly rentals in Saint Charles
Guests agree: These family-friendly homes are highly rated for location, cleanliness and more.

The Ella Rose Guest Suite steps from Main Street
Welcome to The Ella Rose Guest Suite! This adorable gem represents everything you love about Old St. Charles. This cozy suite is just steps away from the heart of Main Street, restaurants, and all the action St. Charles has to offer. The Ella Rose is a charming one-bedroom, with an open and airy living room and kitchen. It has natural light and high ceilings throughout. It's farmhouse cottage decor makes for a relaxing place to rest. Come sit and listen to the music of our outdoor bubbler rock.
KitchenFamilyHospitality

Cottage on Main Street- Low Cleaning Fee
MESSAGE FOR SHORT STAY DISCOUNT Stay in the heart of Historic Downtown St. Charles! WALK EVERYWHERE at this beautifully updated 2BR/1BA blends modern comfort with charm just steps from Main Street. Walk to award-winning restaurants, unique boutiques, coffee shops, festivals, and riverfront views. Directly across from the Katy Trail, perfect for biking and morning strolls. Minutes to Ameristar Casino and 12 minutes to STL Airport. Fast Wi-Fi, cozy beds, and an unbeatable location. See you soon!
KitchenFamilyOutdoor spaces

Main Street Hideaway
This house is located on historic Main Street in Saint Charles, Missouri. This means we are within walking distance of dozens of restaurants and boutique shops. We are in the wedding district and three wedding venues are within a 5 minute walk: The Old Stone Chapel & LaBelle Couer. This is the perfect spot for bridal parties and families. This unique house, is a perfect spot for a bridal party to get ready and prepare for the big day. Brand new bath added in 2024. Outdoor patio new in 26
FamilyKitchenGetting around

301 Guesthouse- Historic Main street-Katy Trail
Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!
FamilyIndoor spacesCheckout

Tompkins Street Retreat
Relax in this two-bedroom, two-bath house with a backyard patio and firepit with a privacy fence. Walk to unique shopping and entertainment on Historic St. Charles Main Street. Local wineries and St. Louis attractions are a short drive away. Enjoy a comfortable living room with a large TV and a fully equipped kitchen for special meals. Unwind after an active day with a meal, drinks under the pergola, and a great night's sleep in our king-size bed. We also offer FREE off-street/garage parking.
FamilyIndoor spacesDecor

Cozy Mid-Century Modern Townhome
This comfy 2 bedroom, 1.5 bath townhome is perfect for up to 5 guests. Luxury King bed in bedroom 1 and luxury Queen bed in bedroom 2. A futon in the living room can be used for a 5th guest. A pack-n-play is available upon request. This dynamic location is 5 minutes from bars, restaurants, shopping, Lindenwood University, and Ameristar Casino. It's only 2 miles from St. Charles, historic, Main Street, and it's only 15 minutes from the airport, and about 30 minutes from downtown St. Louis.
Indoor spacesFamilyQuiet

Patio House, secluded in heartbeat of Main Street
The Patio is nestled in the heart of historic St. Charles a few steps from Main Street, Katy Trail, Missouri River, Antique and Boutique Shopping, Restaurants Bars and More, Several Wedding venues are within walking distance of the property as well. In addition to your well appointed unit, this property has as much outside as it does in. Take your coffee, wine, water and enjoy our patio, complete with fire table, dining table edged with lush plantings for privacy. PLEASE NOTE NO SMOKING
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*NEW HotTub* The Jewel on 5th-2br2b-near Main
A true gem only a 15 min drive from the STL Airport. Enjoy a well equipped, century home a short 12 min walk to Historic Main and a HOTTUB. The large stocked kitchen is great for entertaining. Master bedroom w/luxurious, king sized, 4 poster bed and ensuite bathroom awaits you. In the private, queen suite you’ll find its own bathroom and another door leading onto the deck. The chair off the kitchen folds out to a standard twin and bedding is provided for the sofa as well. Can sleep 6.
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Family/4bd/2bth/Huge Yard/Playset/Ping-Pong/Arcade
Our freshly updated and furnished house is ready for the family with kids, the adult getaway, and wedding parties from Stone House event venue across the street! Boasting tons of privacy, a huge yard with a playset and games, a fully stocked kitchen with everything you could want for a Thanksgiving dinner, and a large basement with arcade boxes, ping pong, weights, and seating areas. A very safe and secluded location that is close to amazing parks, restaurants, wineries, and shopping.
KitchenIndoor spacesTV

Bright & Cozy Shotgun DPX 1 Block from Historic DT
Admire this unique historic home's design with brand new amenities and antique details that give a fresh and charming feel. Built in the late 1800's, this half of the duplex has a typical shotgun layout with ten-foot ceilings giving a spacious feel. The front door leads directly to the living room, then into the bedroom, both of which have the original hard wood floors. The back of the house has the kitchen, with exposed brick, a dining area, and a bathroom with a washer and dryer.
FamilyIndoor spacesPets

Camp Mill Pond: Historic Cabin Near Main Street
*St. Louis Magazine A-List Winner!* ***PRESS: DESIGN STL, STL MAG, AND FOX2NEWS*** Camp Mill Pond is a throwback to the slow and easy rhythm of hot summer days. This circa 1835 cabin offers easy access to our historic area, including Main Street, Katy Trail for biking, and Frenchtown, without sacrificing modern comforts! This 180-year-old historic cabin sits on a beautiful lot, shared with our 1865 three-story home and a two-story carriage house. Ask about renting bikes! 🚲
Indoor spacesFamilyCondition

The Frenchtown Inn | 2BR Charmer
Welcome to the Frenchtown Inn on the corner of Third and French! Experience the best of St. Charles in this charming 2-bedroom, 2-bathroom house situated in the heart of Frenchtown. This delightful space offers a perfect blend of comfort, convenience, and a touch of history, ideal for an unforgettable stay. We are dog friendly, complete with a fenced in yard. The Frenchtown Inn awaits you. Come experience a memorable, relaxing getaway with family or friends in our inviting home!
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Popular amenities for Saint Charles family-friendly rentals
Family-friendly home rentals with a hot tub

“HOT TUB” Oasis in the heart of the city!
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Luxury Getaway | Hot Tub, Pool Table & Garage
Indoor spacesFamilyPets

Spacious home with entertainment room and hot tub
FamilyIndoor spacesTV

Roomy Oasis with hot tub on the Hill!
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Cul De Sac - next to the best shopping in STL
KitchenFamilyAir conditioning

Lodge at Pine Lake - Hot tub, lake, pets welcome
KitchenIndoor spacesPets

Romantic tiny home w/ hot tub
Indoor spacesKitchenHospitality

The Soulard Atelier- Hot Tub!
KitchenFamilyValue
Family- and pet-friendly home rentals

The Benton House - With fenced yard!
Indoor spacesFamilyCheckout

Cozy Home in Wentzville Sleeps 6 + Game Room
KitchenIndoor spacesHeating

The Little House.
FamilyKitchenHospitality

2bed/2bath Walk Main St Shops Eateries & Bars!
Indoor spacesFamilySleep quality

Family Friendly Home Near Parks and Dining
FamilyKitchenCheck-in

Route 66 Railroad Shanty, a cozy artsy small space
Indoor spacesKitchenNearby

The Ladybug Inn
FamilyKitchenBackyard

Pacific Palace, super unique!
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Family-friendly home rentals with a pool

Private indoor pool & sauna
FamilyKitchenCleanliness

'Hidden Paradise' on 5 Acres w/ Hot Tub & Deck!
KitchenIndoor spacesQuiet

Blair's Pool House - Creve Couer Hot Tub Game Room
FamilyIndoor spacesParks

"The Villa" at Villa Augusta in MO wine country
Indoor spacesFamilyComfort

Spacious Home - Heated Pool Open - Amenity Packed
KitchenIndoor spacesAmenities

Sunset Mountain Privacy
KitchenFamilyLong stay

Secluded Property w Pool and Hot Tub
KitchenFamilyLocation

Dogwood cabin S-7
FamilyIndoor spaces
Destinations to explore
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- Springfield Holiday rentals
- Busch Stadium
- Central West End
- Six Flags St. Louis
- Saint Louis Zoo
- The Dome at America's Center
- Enterprise Center
- St. Louis Aquarium at Union Station
- Gateway Arch
- City Museum
- Missouri Botanical Garden
- Washington University in St Louis
- Forest Park
- Hidden Valley Ski Resort
- Meramec Caverns
- Saint Louis University
- The Pageant
- Castlewood State Park
- Gateway Arch National Park
- Soulard Farmers Market
- Saint Louis Science Center
- Saint Louis Art Museum
- Westport Plaza
- Cathedral Basilica of Saint Louis
- Missouri History Museum





