
Holiday houses in O'Brien
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Top-rated holiday rentals in O'Brien
Guests agree: these stays are highly rated for location, cleanliness and more.
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Holiday rentals for every style
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Popular amenities for O'Brien holiday rentals
Other great holiday rentals in O'Brien
Superhost

Home in Lake City
4.8 out of 5 average rating, 56 reviewsLake City Luxury New listing whole house
Top Guest favourite

Home in Lake City
4.97 out of 5 average rating, 59 reviewsCute & Cozy FL Home
Top Guest favourite

Home in Live Oak
5 out of 5 average rating, 54 reviewsNature + Music + Town | Cozy Farmhouse Retreat
Top Guest favourite

Cabin in Branford
5 out of 5 average rating, 15 reviewsGong with the Wind
Guest favourite

Home in Lake City
4.93 out of 5 average rating, 59 reviewsModern & Convenient 3/2 Home
Top Guest favourite

Guesthouse in High Springs
5 out of 5 average rating, 19 reviewsWalk to Downtown* Close to Springs* Jacuzzi Tub*
Top Guest favourite

Guesthouse in Bell
4.95 out of 5 average rating, 20 reviewsStudio on Suwannee River w/adjacent boat ramp
Superhost

Cabin in McAlpin
4.79 out of 5 average rating, 39 reviews2 story Florida Cypress Cabin
Destinations to explore
- Seminole Holiday rentals
- Central Florida Holiday rentals
- Saint Johns River Holiday rentals
- Orlando Holiday rentals
- Florida Panhandle Holiday rentals
- Atlanta Holiday rentals
- Destin Holiday rentals
- Tampa Holiday rentals
- Kissimmee Holiday rentals
- Four Corners Holiday rentals
- Panama City Beach Holiday rentals
- Charleston Holiday rentals
- Ginnie Springs
- Ichetucknee Springs State Park
- Gilchrist Blue Springs State Park
- Manatee Springs State Park
- Madison Blue Spring State Park
- Keaton Beach
- Shired Island Trail Beach
- Depot Park
- Ironwood Golf Course
- Florida Museum of Natural History
- Fanning Springs State Park
- Suwannee Country Club
- Horseshoe Beach Park
- Suwannee River State Park