Holiday houses in Santa Fe Lake

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Top-rated holiday rentals in Santa Fe Lake

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite

A wooden dock extends over the water towards a two-story house, featuring a spacious patio with seating. The grassy area around the house is shaded by trees draped in Spanish moss, contributing to a serene outdoor environment.

Home in Waldo

Lake Santa Fe House Amazing Views Sunrise Sunset

Make memories for a lifetime on Santa Fe lake in Earleton . This a great place to stay for Gator events with a 20 minute commute to Gainesville. The house is in a paved neighborhood for walking or biking. Beautiful sunrises and sunsets with your unobstructed lake view . The house is comfy and cozy for the whole family to come enjoy. Whether you are into water sports, fishing, or just want a nice quiet getaway this place offers it all. Right on lake, with your private boat ramp, dock and beach

FamilyLocationHospitality

4.97 out of 5 average rating, 38 reviews

Guest favourite

A serene lakeside scene is depicted with a wooden dock extending into calm waters. Nearby, colorful Adirondack chairs surround a fire pit, creating a space for relaxation. The background features trees reflecting the hues of sunset, enhancing the tranquil atmosphere.

Home in Hawthorne

Serenity Escape lake house private beach

Serenity Escape at Hawthorne Lake Escape the hustle and unwind at Serenity Escape, a peaceful lakeside retreat nestled in the heart of Hawthorne, Florida. Whether you’re planning a family vacation, fishing trip, romantic getaway, or relaxing weekend with friends, this beautifully appointed home offers the perfect blend of comfort, privacy, and natural beauty .Wake up to breathtaking lake views, sip your morning coffee from the screened porch, and spend your days enjoying on our private beach🏖️

ValueLocationKitchen

4.95 out of 5 average rating, 102 reviews

Superhost

The living area features a comfortable leather sofa and a patterned chair, complemented by a wooden coffee table. A vibrant area rug with floral and butterfly designs adds color to the space. Large windows provide natural light, and a wall art piece showcases a flower.

Cottage in Earleton

Lake Santa Fe Cottage #3 - 2BR 1BA, Sleeps 4

Spacious 2 BDRM 1 BA lakeside cottage on Lake Santa Fe in Earleton. Private and gated with direct lake access with six rental cottages. A peaceful, quiet space to unplug and get away from the daily chaos. If you have and boat AND/OR TRAILER during your stay there is a fee of $20 regardless of whether or not you choose to use our private launch. Please respect maximum number of overnight REGISTERED guests on your reservation. If others join your group there is a $15 per person fee per day.

FamilyLocationTV

4.97 out of 5 average rating, 33 reviews

Top Guest favourite

A charming log home is nestled among large trees draped in Spanish moss, with a well-kept grassy area leading to the lake. The porch is visible, and the peaceful water serves as a backdrop, enhancing the natural beauty of the surroundings.

Cabin in Hawthorne

Charming Lakefront Log Home

Welcome to your perfect lake retreat! Located on a no public access lake. This charming log home has a private dock and boat ramp suitable for launching your boat for fishing or skiing. There are kayaks on premises for use. This is an ideal location to enjoy North Florida’s lake life with family, friends, or work retreat. Includes a fully stocked kitchen, covered porch, fire pit, gas grill, and WiFi if you feel the need to plug in. NOT suitable for parties or events. NO loud noise, please.

ValueLocationBarbecue

4.97 out of 5 average rating, 183 reviews

Guest favourite

Two comfortable chairs are positioned on a wooden deck overlooking a calm lake, surrounded by a serene landscape. The expansive water reflects a blue sky, creating a peaceful atmosphere for relaxation and enjoyment.

Home in Melrose

Modern LAKE HOUSE on Lake Santa Fe near Gville/UF

Have fun OR relax at this fully renovated LAKE HOUSE w/BOATHOUSE and raised sunset deck only 30 mins to Gainesville! Sit back and and enjoy the beautiful views of the lake as soon as you enter the home or up close from the hammock swings in the boat house! 3 BR/2 BA plus converted air conditioned garage used as a game room with Ping Pong Table and TV, easily sleeping 8. The backyard offers a large deck with privacy fencing and lush landscaping with direct access to step right into the lake.

LocationFamilyIndoor spaces

5.0 out of 5 average rating, 26 reviews

Guest favourite

Large windows frame serene lake views, showcasing the natural landscape outside. A cozy sofa with an orange accent pillow is positioned towards the view, while a lamp and decorative plant add subtle elegance to the interior space.

Home in Melrose

Lake Santa Fe Estate Home

Forget your worries in this spacious and serene space on beautiful Melrose Bay. Walking distance to the restaurants and shops of downtown Melrose, close to Melrose Bay Park and Lake Santa Fe Park, minutes by car to UF, Keystone Heights and Gainesville. The house boasts beautiful lake views throughout, a spacious modern well stocked kitchen, open and very functional floor plan, large master suite with walk in closets and attached master bath, wonderful screen porch with outside eating.

FamilyLocationAmenities

5.0 out of 5 average rating, 11 reviews

Guest favourite

A figure glides across the water at sunset, creating ripples in the smooth lake surface. The sun casts a golden reflection, enhancing the serene ambiance. Soft clouds are visible in the sky, adding depth to the tranquil scene.

Cottage in Melrose

The Nest on Lake Santa Fe in Melrose, FL

The Nest is a beautiful two-story cottage on Lake Santa Fe. Enjoy some peace and serenity, catch monster bass, or bring your ski boat for high-speed fun. We are located just 20 minutes from Gainesville and UF. The Nest is great for a weekend getaway or a week of peaceful relaxation. We do not allow parties or events out of respect for our neighbors and we allow a maximum of 6 guests (max 4 adults). Absolutely no animals are allowed on the property at any time for any reason.

FamilyLocationQuiet

4.98 out of 5 average rating, 110 reviews

Top Guest favourite

A serene lakefront view features two kayaks and a canoe resting on sandy shores. A wooden dock extends into the calm waters, while fluffy clouds drift across a bright blue sky. Lush greenery surrounds the tranquil setting, creating a peaceful outdoor space.

Home in Keystone Heights

4/3 Lake House on Lake Geneva in Keystone Heights

Bring the whole family to this amazingly restored Florida lake home with lots of room for fun. Swim in the lake, catch some fish, build a sandcastle, make s'mores, nap in the sunroom, play fetch with your dog in the fenced yard, and so much more. Only an hour away from the beaches and the many springs of North Florida. The 1940's "Camp Blanding" house has had a complete makeover giving it the feel of an "Old Florida" lake house with all the comforts of modern living.

LocationFamilyAmenities

4.97 out of 5 average rating, 106 reviews

Top Guest favourite

A clean, functional kitchen area is visible, featuring a white tiled countertop and a stainless-steel sink. In the background, a cozy studio living space offers comfortable seating and colorful furniture. A doorway leads to a private bathroom, enhancing the apartment's practicality.

Apartment in Waldo

Fernbank on beautiful Lake Alto. Laketime Getaway

Visit this beautiful, tranquil lakeside spot for an amazing getaway. It's a six acre property, an inspiring place to study, write, or get work done with fun things to do while on a break. Swim, kayak, canoe, paddle board or enjoy sitting on the dock. Visit the barn for basketball, ping pong, and corn hole. It's a studio apartment with a private bathroom and beds for four, plus two couches and air beds available. Note: This is an upstairs apartment.

ValueFamilySleep quality

4.98 out of 5 average rating, 188 reviews

Top Guest favourite

A wooden dock extends over calm waters reflecting a vibrant sunset. Two Adirondack chairs are positioned atop the dock, offering a serene spot to relax and enjoy the view. The horizon showcases a blend of warm colors as the sun sets gently in the distance.

Apartment in Melrose

Lakefront Retreat Apartment Remodeled, Premium Bed

Private lake home on Big Lake Santa Fe is the perfect place to unwind and enjoy gorgeous sunset views. The rental unit is an upstairs separated apartment. It has a cedar interior with a cabin feel that has been renovated with new appliances, flooring and updated bathroom with walk in shower. Bring your boat to cruise the lake or fish and tie up at our dock. Enjoy swimming, water skiing, fishing or just relaxing on the deck.

FamilyLocationHiking

4.99 out of 5 average rating, 134 reviews

Top Guest favourite

A vibrant sunset is reflected on the still surface of Lake McMeekin, featuring a striking blend of orange, pink, and blue hues in the sky. The silhouette of trees borders the water, creating a serene and tranquil atmosphere.

Home in Hawthorne

Harmony Oaks Guesthouse on Lake McMeekin

Enjoy a great getaway at Lake McMeekin. Ours is a beautiful spring fed lake with beautiful sunrises. A private dock with table and chairs is part of the package. Our guesthouse provides a spacious, comfortable, quiet, lake retreat in the country with 30 minutes of Gainesville, Ocala and Palatka. Bring a kayak or canoe... or some fishing equipment and fish off the dock or enjoy the area's many fishing lakes and springs.!

FamilyValueSleep quality

4.96 out of 5 average rating, 228 reviews

Superhost

A charming multi-level home is surrounded by lush greenery and hanging Spanish moss. Arched doorways and windows are featured in the facade, complementing the natural landscape. Sunlight filters through the trees, casting gentle shadows across the inviting walkway leading to the entrance.

Home in Keystone Heights

Unique Spanish Style Lake Home! Kayak-Paddle Boat

Take it easy at this unique and tranquil getaway. On the lake with beautiful views from the sunroom to the large master. Enjoy grilling out or cocktails with a gorgeous lake view. Wake up to coffee on the porch directly off of your master suite. Partake in kayaking, paddle boating or fishing in a spring feed lake while sunbathing on the “White Sands” beached area. Paddle boat and kayak available for guests use.

FamilyLocationPets

4.88 out of 5 average rating, 40 reviews