Vacation rentals in De Soto
Find and book unique accommodation on Airbnb
Top-rated accommodation in De Soto
Guests agree: these stays are highly rated for location, cleanliness and more.
Cottage in Eureka
4.92 out of 5 average rating, 234 reviewsBeautiful Cottage on Large Private Lot
This lovely rural cottage is nestled back in the woods on its very own private acre of land. It offers guests a beautiful getaway experience while walking the property or hanging out on the large covered front porch; while at the same time being just a 7 minute drive from downtown Eureka with its many delicious restaurants and adorable boutiques. If Six Flags is your goal you can enjoy the hustle bustle of the amusement park during the day and relax after a 15 minute drive back to the cottage.
19 – 26 Oct
Cabin in Bourbon
4.92 out of 5 average rating, 356 reviewsLog Cabin at Meramec Farm
A warm, pine honeymoon cabin surrounded by pastoral Ozark countryside. The Meramec River flows through this seventh generation family farm. Cozy interior includes a kitchenette, dining area, and double bed on main level. All your cooking intensils are provided with coffee, tea, and paper products. DVDs and books available await you up the spiral staircase in the loft. Full bed on main level and two singles bed upstairs. Expansive view from your front porch of the highest bluffs on the Meramec.
18 – 25 Sept
Treehouse in Perryville
5.0 out of 5 average rating, 501 reviewsTreeLoft at BaseCamp
Welcome to the TreeLoft experience! This is a custom built luxury treehouse for two. It is our hope that upon your stay you will be reconnected to nature and to the one you came with. We created the TreeLoft with an inspired state of mind, and we are hopeful that same inspiration will be experienced and reflected during your stay. Go to sleep counting stars and wake up with the trees! We can't wait to provide you with the TreeLoft experience! We rise by lifting others!
9 – 14 Sept
Accommodation for every style
Get the amount of space that is right for you
Popular amenities for De Soto accommodation
Other great accommodation in De Soto
Home in Bloomsdale
4.95 out of 5 average rating, 96 reviewsHop off the highway, Relax!
20 – 27 Oct
Cottage in Festus
4.96 out of 5 average rating, 46 reviewsCreek View Cottage at Happy Camp
26 Jan – 2 Feb
Loft in Festus
4.96 out of 5 average rating, 96 reviewsThe Loft at 12A
9 – 16 Oct
Tiny home in Cadet
4.85 out of 5 average rating, 67 reviewsHeavenly Hideaway on the Creek
15 – 22 Apr
Cabin in Leadwood
4.93 out of 5 average rating, 92 reviewsThe Pallet Factory (Cabin 1)
11 – 18 Dec
Cabin in Festus
4.98 out of 5 average rating, 45 reviewsRelaxing Log Cabin Getaway on 20 Acres
24 June – 1 July
Cabin in Park Hills
5.0 out of 5 average rating, 17 reviewsPrivate getaway on 4 acres!
30 Oct – 6 Nov
Cottage in Bonne Terre
5.0 out of 5 average rating, 46 reviews2-bedroom cottage with a gorgeous lake view.
10 – 17 Nov
Farm stay in Bloomsdale
4.89 out of 5 average rating, 36 reviewsCheerful 2 bedroom Farmhouse in Bloomsdale
31 Aug – 7 Sept
Cabin in Ste. Genevieve
4.97 out of 5 average rating, 66 reviewsHoney Hideaways
26 Aug – 2 Sept
Campervan/RV in Fredericktown
5.0 out of 5 average rating, 3 reviewsDaisy, The Groovy Camper
20 – 27 Nov
Cottage in Valles Mines
4.93 out of 5 average rating, 15 reviewsCarol's Cottage
26 Feb – 5 Mar
Destinations to explore
- St. Louis Holiday rentals
- Saint Charles Holiday rentals
- Hermann Holiday rentals
- Innsbrook Holiday rentals
- Cape Girardeau Holiday rentals
- Carbondale Holiday rentals
- Grafton Holiday rentals
- Lake of Egypt Holiday rentals
- Rolla Holiday rentals
- Jefferson City Holiday rentals
- Ste. Genevieve Holiday rentals
- Nashville Holiday rentals
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom