Guesthouse holiday rentals in Anderson County

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Top-rated Guesthouses in Anderson County

Guests agree: These guesthouses are highly rated for location, cleanliness and more.

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Top Guest favourite

A gravel path meanders through a grassy area, flanked by low shrubs and tall trees, creating a serene and natural environment. Soft sunlight casts a gentle glow over the scene, highlighting the rich green foliage and the open field stretching out in the distance.

Guesthouse in Abbeville

Scenic Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

4.97 out of 5 average rating, 380 reviews

Top Guest favourite

A porch swing is set on a wooden deck, adorned with plush cushions featuring intricate patterns. Lush greenery and colorful flowers are visible in the background, adding vibrancy to the serene outdoor setting.

Guesthouse in Six Mile

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

4.96 out of 5 average rating, 188 reviews

Top Guest favourite

A wooden swing is positioned on the deck of the dock, overlooking the calm waters of Lake Hartwell. The serene landscape stretches into the distance, framed by tree-covered shores and a clear blue sky.

Guesthouse in Anderson

Private-Lake getaway-7 mile view from dock

Spacious two story guest house on a private road situated on Lake Hartwell. Use the double deck dock with 7 mile view for all day fishing, swimming or just relaxing. The guest house with central heating and air is fully furnished and has a fully equipped kitchen, wifi, 3 streaming flat screen tvs, two full baths, washer/dryer combo and a large attached deck. Owners live on property but in different residence. Outdoor cameras overlook parking area. Only reserved guests have property access.

4.95 out of 5 average rating, 215 reviews

Top Guest favourite

An inviting entrance features a wooden porch with decorative flowers and a bench. A staircase leads to the upper-level apartment, while an American flag adds a patriotic touch. Natural light illuminates the space, creating a welcoming ambiance.

Guesthouse in Seneca

Hartwell Hideway

Escape to this cozy 1-bedroom, 1-bath apartment perched above a private garage on Lake Hartwell. It's just 15 minutes from Clemson University and quaint downtown Seneca. With a full kitchen, cozy living space, on-site parking, keyless entry, and owners nearby, you’ll have everything you need for a relaxing visit. ✔ New build 2024 ✔ Boat access 5 minutes away ✔ Hiking & waterfalls nearby Whether you're here for a Clemson game, a lake adventure, or a quiet getaway, this is the perfect home base.

4.99 out of 5 average rating, 87 reviews

Guest favourite

A spacious yellow barn-style structure with a green roof is visible, featuring three symmetrical gabled dormers. The ground level includes three garage doors, framed by lush greenery and a wooden fence, with a serene backdrop of trees.

Guesthouse in Anderson

Farmhouse by the lake - Private guest house

1,200 square foot apartment over a quiet barn on a cul-de-sac of a lake community. Near I-85, T. Ed Garrison Livestock Arena, downtown Pendleton, Clemson, and Lake Hartwell. Perfect for Clemson football games, horse/livestock shows or trail riding at Garrison Arena, lay over with horse, graduation, visiting your college student, fishing tournaments, or vacationing near Lake Hartwell. A private guest house overlooking sheep pastures and woods. Accessed by flight of stairs.

4.87 out of 5 average rating, 217 reviews

Top Guest favourite

A spacious living area features a large, L-shaped sectional sofa arranged around a coffee table. A kitchenette with wooden cabinets and appliances is visible in the background, while light flows in through patterned curtains, illuminating the cozy sleeping area with a queen-sized bed.

Guesthouse in Central

Elfwing Carriage House

Bright & comfortable studio apartment located in a quiet family neighborhood in the country, yet minutes to town. We are an easy 15 minute drive to Clemson, less than 5 miles to SWU, 7 miles to Duke Energy. Smart location for the mountains & lakes, visiting colleges, and graduation. Hikes, waterfalls, 12 Mile River & Lake Hartwell are nearby. Friendly dog is fenced or in our home. Come enjoy neighborhood & country living at its finest!

4.98 out of 5 average rating, 225 reviews

Top Guest favourite

Guesthouse in Donalds

Home on the farm

aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.

4.99 out of 5 average rating, 410 reviews

Top Guest favourite

The exterior of the property is shown, featuring yellow siding complemented by dark shutters on the windows. A single door with glass panels is visible, providing a welcoming entrance. A grassy area is located at the base of the wall, enhancing the outdoor setting.

Guesthouse in Liberty

Holly Hideaway! 10 Highway miles to Clemson U!

Holly Hideaway is nestled between Greenville and Clemson, in the small town of Liberty. It's perfect for business travelers, couples, Clemson parents, alumni, and small families. Tiled throughout for cleanliness. Privacy, tranquility, and clean, comfortable accommodations are what we provide. We are 10 minutes from Clemson and 3 miles from SWU. The Hideaway now offers Wi-Fi and Smart TV.

4.93 out of 5 average rating, 217 reviews

Guest favourite

The exterior view of the Shou-Sugi-Ban Guest House features a dark wooden facade with a sloped roof. A spacious deck is present, furnished with two orange chairs and a potted plant. Lush greenery surrounds the area, providing a natural feel.

Guesthouse in Piedmont

Shou-Sugi-Ban Retreat on the Saluda River

The Shou-Sugi-Ban Guest House is 5 miles from Greenville city center and West Greenville, yet you'll feel like you've escaped it all with the rush of the river and surrounding trees. This cozy, custom space has a king-size bed, and two sets of French doors leading out to a private deck. No matter where you are in the space, you'll have views of the 700 ft of Saluda river frontage.

4.97 out of 5 average rating, 143 reviews

Top Guest favourite

A charming cottage is set among lush greenery, featuring a spacious deck that extends from the front. Large windows provide natural light, while surrounding trees and plants create a serene atmosphere.

Guesthouse in Greenville

Sally's Cottage

Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

5.0 out of 5 average rating, 194 reviews

Top Guest favourite

The exterior of the apartment building is visible, featuring a rustic design with wooden elements and a metal roof. A spacious driveway leads to the double garage doors, surrounded by landscaped greenery and blooming flowers. Trees in the background provide a peaceful environment.

Guesthouse in Hartwell

1 bedroom lake front apartment with gorgeous views

Relax in a cozy apartment on Lake Hartwell. The apartment is located in a secluded peaceful, cove near downtown Hartwell and is in close proximity to hiking and numerous outdoor activities in the hill country of Georgia and South Carolina. The apartment sleeps 2 comfortably and is fully equipped with a kitchen and a private laundry facility.

4.98 out of 5 average rating, 179 reviews

Top Guest favourite

A charming exterior of a detached garage apartment is displayed, featuring a covered porch with a swing. A neatly landscaped area is visible, along with a gravel driveway leading to a spacious garage with multiple windowed panels.

Guesthouse in Abbeville

1-bedroom guesthouse in Abbeville, SC

A lovely 1 bedroom apartment in our detached Garage. Everything is new, clean and up to date. Built in 2020. One queen bed and one couch that pulls out into a full size bed. Only 8 minutes from Erskine College and 21 minutes from the Diamond Hill Mine.

4.97 out of 5 average rating, 183 reviews