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Holiday houses in Santa Cruz

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness and more.

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Top Guest favourite
Loft in Iztapalapa
5.0 out of 5 average rating, 29 reviews

Private Microsuite Const 1917 Iztapalapa

Beautiful and modern private microsuite in the east of CDMX, ideal for couples, business trips, family visits or relaxation. It has a double bed, full bathroom, Wi-Fi, desk, TV, closet and kitchenette with sink. Near Constitución de 1917, with connections to the Metro, Trolebús Elevado and Cablebús. If you come for work, you can request a coworking space or a professional room at Punto de Negocios, across from the accommodation, subject to availability through Airbnb. Your private base for getting around better.

LocationFamilySleep quality

Top Guest favourite
Condo in Condesa
5.0 out of 5 average rating, 13 reviews

Designer Stay in Condesa

A warm, elegant and carefully curated apartment located in the heart of La Condesa, one of Mexico City’s most beautiful and walkable neighborhoods. Designed with organic textures, soft neutral tones, the apartment creates a calm and elevated atmosphere perfect for relaxing after exploring the city. Natural light fills every corner of the space throughout the day, highlighting handcrafted details, warm wood finishes and cozy layered textiles that make the place feel both luxurious and inviting.

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Top Guest favourite
The kitchen area features a wooden dining table surrounded by chairs, with natural light streaming through large windows. A cozy seating area with cushions is visible in the background, complemented by indoor plants. The space is designed for socializing and enjoying meals.
Casa particular in Coyoacán
4.99 out of 5 average rating, 78 reviews

Unique house in Coyoacán

Our house is a unique space, its architecture design is conscious and sensitive to its environment, taking care of the entry of natural light into every corner. Due to its design, each corner tells a story and allows you to create intimate and creative moments without losing contact with the other corners of the house and with the other people who accompany you. On three levels you will find everything you need to rest, to create, to work, to do yoga, to cook, to relax, to read and more!

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Guest favourite
A spacious living area is depicted, featuring a round glass dining table surrounded by six woven chairs. A wooden bookshelf filled with books is visible in the background, along with a comfortable seating area containing a dark sofa. A large television is mounted on the wall.
Loft in Xochimilco
4.91 out of 5 average rating, 89 reviews

Beautiful suite with a separate entrance

Relax on this unique and quiet getaway in this beautiful space surrounded by nature. Beautiful garden and architecture. Close to attractions in Xochimilco such as the trajineras and the canals and chinampas of Xochimilco and Cuemanco. Traditional village south of the city. Relax in our beautiful place, surrounded by nature. Beautiful green garden and architecture. Close to main attractions like Trajineras, Xochimilco town, canals and chinampas. Traditional town south of the city

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Top Guest favourite
Apartment in Roma Norte
5.0 out of 5 average rating, 9 reviews

Designer's Haven in Roma with Private Rooftop

Experience Mexico City like a local from this beautifully designed three-story home in the heart of Roma Norte. Walk to the city's best restaurants, cafés, boutiques, galleries, and parks. Accommodates up to 6 guests with 3 bedrooms, 3 full bathrooms, a spectacular private rooftop terrace, 4 Smart TVs, private elevator access, parking, and 24/7 security. A rare combination of space, privacy, design, and location in one of the city's most desirable neighborhoods.

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Superhost
An open-plan living area features a dining table with black chairs and a contrasting wooden surface. Natural light floods the space through large windows, illuminating a relaxed seating area and green plants. Decorative wall pieces add character to the minimalist design.
Loft in Coyoacán
4.88 out of 5 average rating, 226 reviews

Casa Mavi's loft in Coyoacán

Welcome to Coyoacán! Great 120 m2 loft located just a 5-minute walk from downtown Coyoacán. Experience this quiet and bright open space, ideal for resting or working and decorated with objects full of stories. The loft is located on the third floor of Casa Mavi, an old factory that was remodeled to create a place full of charm that makes it unique. It has shared terraces. With option for a third guest. 200 megabyte Wi-Fi.

LocationFamilyAccess

Guest favourite
A cozy bedroom features a spacious bed with a soft grey headboard and decorative cushions. A sleek bedside lamp provides gentle illumination, while modern wooden cabinetry adds warmth to the space. A grey armchair is positioned nearby, complemented by delicate white flowers in the foreground.
Loft in Tlalpan
4.88 out of 5 average rating, 930 reviews

Punto Lofts Periférico Sur (South Peripheral Point Lofts)

Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.

LocationFamilyBathroom

Top Guest favourite
Loft in Ayapango
5.0 out of 5 average rating, 19 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

AccuracyWi-FiWalkability

Guest favourite
Cabin in Tlalmanalco
5.0 out of 5 average rating, 12 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

LocationIndoor spacesBathroom

Guest favourite
A spacious rooftop terrace is highlighted with a covered seating area, featuring a low table and cushioned seating. Lush green plants are dotted around, adding a natural touch. Soft lighting is suspended above, creating an inviting environment. A wooden privacy wall is partially visible in the background.
Home in Xochimilco
5.0 out of 5 average rating, 12 reviews

Rooftop & SmartHome in Xochimilco-Live enjoy Relax

Stay in a fully equipped luxury apartment designed for comfort and convenience. Unwind on your private rooftop terrace and enjoy a Smart Home experience. Your stay includes a fully equipped kitchen, washer, high-speed WiFi, and free parking. Ideally located near Xochimilco’s Historic Center, with easy access to public transportation, restaurants, cafés, and the city’s main roads.

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Top Guest favourite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 109 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

FamilyValueSleep quality

Top Guest favourite
The exterior of a two-story house is surrounded by lush greenery and vibrant planters. A small terrace features a white umbrella, where a person is seated, enjoying the garden view. A paved pathway leads to the entrance, enhancing the welcoming atmosphere.
Loft in Del Carmen
4.95 out of 5 average rating, 256 reviews

Loft Coyoacan Viveros (Bow)

A super special and very cozy place in the heart of Coyoacán! right next to Coyoacán nurseries, on Melchor Ocampo street Ideal for a couple with or without children who want to enjoy a pleasant stay or a good walk through the wonders of Coyoacán :)

LocationFamilyCondition

Popular amenities for Santa Cruz holiday rentals