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House holiday rentals in Guadalupe

Find and book unique houses on Airbnb

Top-rated house rentals in Guadalupe

Guests agree: These houses are highly rated for location, cleanliness and more.

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Guest favourite
Home in Arroyo Grande
4.93 out of 5 average rating, 416 reviews

Beach-themed farmhouse with indoor fireplace

As 23-time Superhosts- we welcome you to the perfect place to relax & unwind after your day. This stylish and spacious home offers a sunny deck, surrounded by trees for sunbathing or watching the sunset. The huge 2nd bdrm is a great place for reading in our hammock chair or for a quiet work space. Downstairs the fully equipped kitchen has everything you need for cooking meals. Outdoor patio is a nice place to bbq & relax as you listen to the hawks, owls, & other birds in this country setting.

Guest favourite
A sunset sky filled with vibrant colors casts a warm glow over the country house. The exterior is highlighted by large windows and a welcoming entrance. The driveway leads towards the home, bordered by manicured landscaping, set against a backdrop of rolling hills.
Home in Arroyo Grande
4.83 out of 5 average rating, 307 reviews

Coastal Getaway, Country House, near 101 FWY

Country house surrounded by trees with many windows, wooden floors, lovely kitchen, large sunroom, and huge deck. All located just minutes from Pismo, Grover, Shell and Avila Beach, hot springs, hiking areas, wineries, golf courses, Lake Lopez, ATV riding & outlet shopping, Trader joe's and many other stores. San Luis Obispo is a lovely city just minutes north. and Hearst Castle is less than an hour's drive North. Conveniently situated off the 101 freeway, a nice retreat from the big city.

Guest favourite
A spacious kitchen area features rich wooden cabinetry and a large gas range beneath a sleek exhaust hood. A mosaic tile backsplash adds texture, while natural light streams in through nearby windows, illuminating the granite countertops and various kitchen appliances.
Home in Arroyo Grande
4.91 out of 5 average rating, 167 reviews

Beautiful Country Home

Bring your family and friends to this beautiful, country Home just ten minutes from the beach. Rancho de la Cabeza is a peaceful, rustic ranch nestled between world class wineries, orchards, farms, golf courses, and the amazing beaches on the Central Coast! Are you looking to host a larger group? We have a smaller house on the same property. Both houses combined can sleep 18 people. Up to two dogs are allowed. $25 per pet fee. Smaller house: airbnb.com/h/central-coast-peaceful-haven

Top Guest favourite
A welcoming living area features a high ceiling with a chandelier hanging above. Large glass doors allow natural light to fill the space, complemented by soft curtains. Comfortable seating arrangements include a dark blue sofa and a patterned armchair, enhancing a cozy atmosphere.
Home in Los Alamos
4.97 out of 5 average rating, 173 reviews

Eagle Creek Ranch 1/2 Block from Bell Street

Eagle Creek Ranch is my special place. I fell in love with it and I knew it was for me. I continue to pour my heart into the property and I love to share with others. The wifi is good. Several times a year it might be out for a few hours or so . There is ample parking. You might see the resident bobcat and fox through every day. You’re a 10 second walk from downtown Bell Street. Freeway, east of property, can be heard on north side of house only. Small gatherings allowed (w/ permission).

Top Guest favourite
A single-story ranch house features a red-tiled roof and white stucco walls. Flanked by several trees, the entrance is accentuated by wooden double doors. The sky above is clear with soft clouds, contributing to the serene outdoor setting.
Home in Nipomo
4.9 out of 5 average rating, 173 reviews

Working Ranch~Golf, Beach,Wine/No smoking/Pet free

***At this time we are not set up to host weddings or public events.*** Escape the city to this ranch retreat surrounded by working farms. This 3-bedroom, 4-bath vacation home is on a full-time ranch in the heart of California’s Central Coast, halfway between Los Angeles and San Francisco, just 2 miles from Highway 101. Golf, wineries, and hiking are minutes away. Avila Beach, Pismo Beach, Cal Poly and San Luis Obispo are a 15–20 minute drive. Stays of 30+ days available upon request.

Guest favourite
Home in San Luis Obispo
4.94 out of 5 average rating, 136 reviews

San Luis Obispo Wine Country Retreat

Escape to a charming three-bedroom farmhouse on a shared 10-acre ranch in San Luis Obispo's Edna Valley. Newly renovated with modern amenities including a spacious kitchen, cozy living room with smart TV, and private patio with fire pit. Sleeps up to six guests with stunning views of rolling hills. AC, heating, WiFi, and BBQ grill included. Explore nearby wineries and restaurants or relax on the private patio. Long term stays allowed. Book now for a memorable California getaway.

Guest favourite
A modern living area features a large, flat-screen TV against a white wall. A surfboard is mounted beside a fireplace, and a round glass-top coffee table is set on a blue-patterned area rug. Natural light filters through sheer curtains.
Home in Oceano
4.95 out of 5 average rating, 192 reviews

Casa Del Mar

Enjoy a little getaway in this cottage by the beach. It’s cozy and simple with all the features of comfort. Walking to the beach is a just a short stroll down a windy little road filled with cool beach vibes. Cross a little wooden bridge and walk down a block or two and you are right in front of the Oceano dunes. Plan a bonfire and make s’mores on the beach. Or better yet, stay at the little cottage, grab a bottle of wine and enjoy a fire pit right outside your bedroom door.

Top Guest favourite
A small outdoor table is situated in a serene garden setting, featuring two wine glasses filled with red wine and a bottle nearby. A potted succulent adds a touch of greenery, surrounded by various plants, creating a tranquil atmosphere for relaxation.
Home in Santa Maria
4.96 out of 5 average rating, 141 reviews

Cozy Plant-Filled Loft in Orcutt

Stylish, plant-filled loft on the Central Coast! Relax under cozy lights surrounded by greenery in this peaceful, thoughtfully designed studio with everything you need. Enjoy a comfy living area with TV, kitchenette, WiFi, and private entrance for easy access. Located just minutes from Old Orcutt’s coffee shops, wine tasting rooms, and restaurants, with quick access to Solvang, SLO, and beaches. Perfect for a quiet getaway, work stay, or exploring the beautiful Central Coast.

Guest favourite
A spacious bed is centered in the room, adorned with white linens and accented by two light blue pillows. A cozy yellow blanket is draped across the foot of the bed. Two bedside tables with modern lamps provide soft lighting, enhancing the calm atmosphere.
Home in Orcutt
4.96 out of 5 average rating, 228 reviews

Luxe Hideaway: Prvt Patio BBQ Winery, 20 min-Beach

Agreement: Bookings require a signed Renter Agreement, please check your email to complete booking. Kick back & relax in this calm, modern space. Enjoy the privacy of your own home with contactless check-in, high speed internet, comfortable beds, pull-out memory foam sofa sleeper for added guests, full kitchen just waiting for your culinary desires, and a patio with dining set for 6. Enjoy being centrally located while you explore the beautiful central coast.

Guest favourite
A light and airy kitchen features a wooden dining table surrounded by curved-backed chairs. A vintage-style refrigerator and stove are visible, complemented by a pendant light hanging above. Natural light enhances the warm wooden tones of the cabinetry and flooring, creating a welcoming cooking space.
Home in Los Alamos
4.87 out of 5 average rating, 385 reviews

Wine cellar House

Welcome to Bodega House, a restored 1920s farmhouse in the center of Los Alamos. The home features a serene queen bedroom and a separate lounge space, along with a sleeper sofa in the living area. Thoughtfully designed for two adults, the house can also comfortably host one to two children on the sleeper sofa. It’s an ideal setting for couples or small families seeking the ease and privacy of a home while being just steps away from the best of Los Alamos.

Guest favourite
A bright and airy living space features a large window allowing natural light to fill the area. The room includes a cozy seating arrangement with a gray sofa, a wooden dining table with chairs, and decorative wall baskets. A kitchenette is visible in the background.
Home in San Luis Obispo
4.96 out of 5 average rating, 388 reviews

Wine Country Hilltop Retreat

Kick back and relax in this calm, stylish space with spectacular Edna Valley views. Read a book on your hillside patio and see buffalo and longhorns grazing in neighboring fields. After an incredible sunset, unwind by your firepit at night under a sky full of stars. This private country escape is also at the center of it all - 15 minutes to beaches & Cal Poly, 5 minutes to airport & 20+ wineries/tasting rooms, 10 minutes to beautiful downtown SLO.

Guest favourite
A bright living room is presented with natural light streaming through a window. Two comfortable chairs with soft throw blankets face a modern TV mounted on a pale wall. Decorative plants enhance the space, complemented by a wooden coffee table and light hardwood flooring.
Home in Arroyo Grande
4.93 out of 5 average rating, 261 reviews

Mid-century home in the heart of Arroyo Grande.

Welcome to the Eman House! I can't wait to host you at the 1950's mid century in Arroyo Grande, CA. Enjoy the beautiful remodeled kitchen, private backyard and patio, and two cozy bedrooms while soaking up the best of the central coast. Just a 10 minute walk to the historic Arroyo Grande village, a 5 minute drive to the beaches of Grover, and tucked away in one of Arroyo Grande's most peaceful cul-de-sacs.

Popular amenities for Guadalupe house rentals