Holiday houses in De Soto

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Top-rated holiday rentals in De Soto

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Top Guest favourite
Cabin in Carbondale

Gorgeous Cabin close to SIU/wineries/Shawnee

Beautiful cabin sitting in the middle of woods w/ a large entertaining deck that makes you feel like are " away from it all" even though you are 3 mins away from SIU! Features 4 bedrooms & 2 full baths with an open floor plan with plenty of room for family and friends! Enjoy the large deck to grill or to just enjoy a glass of wine from one of our local wineries. Large master suite with jacuzzi tub to unwind. Make use of the concrete party pad with firepit & bar/ game room. Location is perfect!

4.97 out of 5 average rating, 119 reviews
Guest favourite
Home in Carbondale

The Blue House

The Blue House Step back in time—without sacrificing comfort—at this stunningly restored Italianate home nestled in the heart of Carbondale. This spacious two-story blends timeless charm with modern updates, creating a special experience for anyone seeking a unique and memorable stay. Four beautiful bedrooms and 1.5 baths, offers plenty of room to relax and recharge. Original wood floors, big windows, and a grand staircase speak to the home's history, while contemporary touches ensure comfort.

5.0 out of 5 average rating, 20 reviews
Top Guest favourite
The exterior of a charming cottage features a welcoming entrance with a light-colored door. Two blue chairs and a small table are positioned on a stone path, surrounded by well-maintained grass and flower pots. In the background, horses can be seen grazing in a fenced pasture.
Guesthouse in Carbondale

Homestead Cottage

Enjoy tiny farmhouse life in this adorable 375 sq. foot cottage. Loaded with everything you need this little cottage is nestled privately behind some trees on our 11 acre farm. You will soon forget how close you are to town with the beautiful view from your windows and the pasture fence just steps out the back door. Whether you’re here for the wineries, amazing hiking, an SIU event (3 miles) or to visit with family, the Homestead Cottage will provide a comfortable retreat from any adventure.

5.0 out of 5 average rating, 310 reviews
Top Guest favourite
A charming log cabin is framed by vibrant autumn foliage, with trees and shrubs displaying various shades of orange and green. A circular driveway leads to the entrance, where a welcoming porch provides a space to enjoy the surrounding nature and seasonal changes.
Home in Murphysboro

Embers of Murphysboro

Escape to the beauty of Embers of Murphysboro.  The sprawling landscapes and cabin with high end amenities have everything to offer for a weekend getaway or larger gathering.  Sucumb to the beauty of nature around you that will awaken your inner senses and relax your mind.  Nestled upon a  26 acre property the cabin will astound you with picturesque landscapes and a lodging infused with both character and luxury.  Explore local wineries, hiking trails, fishing,  boating , dining and more...

4.98 out of 5 average rating, 172 reviews
Guest favourite
A comfortable living room features a brown leather sectional sofa adorned with several pillows and a soft throw blanket. A wooden coffee table is centered in the room, accompanied by a decorative plant and lamp, creating an inviting relaxation space.
Guesthouse in De Soto

Farm Views From Cozy Guesthouse

Enjoy this comfortable guesthouse/duplex located on the edge of a peaceful 11 acre family homestead just down the road from Walker’s Bluff Casino! You are just 1.5 mi from Walker’s Bluff Casino, 3.4 mi to Carbondale, 5.5 mi to SIUC, and 13 mi to Giant City State Park, and close to the Wine Trail! All three bedrooms offer new memory foam mattresses. The large eat-in kitchen has all of the basics that you might need to make a delicious meal at home. On-site laundry available in the unit.

4.94 out of 5 average rating, 62 reviews
Guest favourite
Home in De Soto

Awesome House in DeSoto

Welcome to this Awesome Home centrally located in Southern Illinois available for your enjoyment while in the area. Featuring a Large Furnished Kitchen, Livingroom, Laundry Room, Three Fully furnished Bedrooms, including TVs, Two Bathrooms, Large Driveway, Extended Wi-Fi Service, and Large Fenced in Backyard with Secure Gated Access for RV's, with 30-amp Electric Plugs and Water available for slight upcharge. I am personally available to ensure that your check-in and stay is enjoyable.

4.92 out of 5 average rating, 13 reviews
Superhost
A gravel pathway is bordered by lush greenery and natural stone slabs. The route leads through a landscaped area featuring shrubs and trees, contributing to a serene and inviting outdoor environment.
Home in Marion

Frank Lloyd Wright design inspired house

PET FRIENDLY-Frank Lloyd Wright design. This home is Unique and spacious! It is conveniently located near interstate 57, and 12 minutes from the Lake of Egypt. It is also close to Shawnee Hills National Forest for beautiful hiking trails and picnics as well as 12 local wineries! After your adventures, Relax in the rustic outdoor area that provides plenty of privacy. Or in the theatre room that has a large tv and recliners to watch your favorite movies or cheer on your favorite team!

4.79 out of 5 average rating, 867 reviews
Top Guest favourite
Cabin in Carbondale

Charmful Cabin Artist respite next to refuge

*No cleaning or pet fees. This Veteran owned Charmful Cabin is stocked with fine Art supplies and ready for your creative Oasis. Sip on your favorite cocktail on the balcony. 1 bedroom, 1 bathroom whole home sanctuary. We are walking distance to the Crab Orchard Wildlife Refuge. A short drive to the Artsy community of Makanda. and an even shorter drive to the food and fun in the college town of Carbondale, LOVE the wine trail? We are aptly located near many wineries.

4.97 out of 5 average rating, 117 reviews
Guest favourite
A cozy living area is furnished with a large sectional sofa and a matching armchair, complemented by decorative cushions. Light filters through window blinds, and a soft area rug covers the hardwood floor. A small table is positioned nearby.
Home in Carbondale

Relaxing 3 Bedroom Cottage in Quiet Neighborhood

This happy 3 bedroom duplex will be a family favorite on your next trip to Southern Illinois. You'll enjoy 3 cozy bedrooms each equipped with a TV, 1 bathroom, ample deck space and firepit. We are located on a quiet street within walking distance of all Carbondale has to offer – Downtown Carbondale, restaurants and pubs (.8 miles), the Memorial Hospital of Carbondale (.5 miles), Carbondale Civic Center (.8 miles), Amtrak Station (.9 miles), and SIU (1.1 miles).

4.87 out of 5 average rating, 342 reviews
Guest favourite
Home in De Soto

Cozy Ranch on Brookside/Serene Country Getaway

Nestled in a peaceful setting and surrounded by open farmland, this home offers the perfect blend of comfort and quiet. With wide-open views and a cornfield just beyond the backyard, you’ll enjoy a level of privacy and calm that’s hard to find. Wake up to quiet mornings and unwind in the evening under the stars. Whether you're visiting nearby wineries, exploring the area, or simply needing a break from the busy pace of life, this is the perfect place to relax.

4.82 out of 5 average rating, 17 reviews
Top Guest favourite
A comfortable living room features a dark gray sofa, two brown armchairs, and a large circular mirror above a decorative table. A rug with intricate patterns lies beneath a coffee table, and a potted plant adds a touch of greenery, with natural light streaming in from a window.
Home in Murphysboro

Convenient Comfy Country Ranch

Kick back and relax in this calm, stylish space. Close to charming, historic Murphysboro, lakes, parks, and wine trails for leisure activities and exploration. An extra room is a great feature, especially for those who work remotely or need a dedicated work space. Ample parking is a bonus for guests looking to bring a boat or meet friends. The large garage makes a versatile space for various needs and activities. Long term stays are welcome!

4.97 out of 5 average rating, 74 reviews
Top Guest favourite
A serene private lake is surrounded by lush trees, reflecting a blue sky. A kayak is on the water, while a small wooden ladder leads to the water's edge. Smooth stones line the shore, creating a peaceful setting for relaxation or water activities.
Cabin in Du Quoin

H & B's...Come experience the magic of nature!

The Cabin is nestled in the woods, a few hundred feet from a beautiful private lake. If it's total solitude you are looking for, this is the place. Keyless entry makes it perfect if you want total privacy. If you want lake access, come down and have coffee with us for orientation. Our pantry items, coffee, granola, half & half, and spices are perfect for your full-service kitchen.

4.97 out of 5 average rating, 177 reviews

Popular amenities for De Soto holiday rentals